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  1. Systematic quantitative methodologies are needed to understand the heterogeneity of cell metabolism across cell types in normal physiology, disease, and treatment. Metabolic flux analysis (MFA) can be used to ...

    Authors: Philip M Tedeschi, Nadine Johnson-Farley, Hongxia Lin, Laura M Shelton, Takushi Ooga, Gillian Mackay, Niels Van Den Broek, Joseph R Bertino and Alexei Vazquez
    Citation: Cancer & Metabolism 2015 3:6
  2. The gene encoding the serine biosynthesis pathway enzyme PHGDH is located in a region of focal genomic copy number gain in human cancers. Cells with PHGDH amplification are dependent on enzyme expression for prol...

    Authors: Katherine R Mattaini, Edward J Brignole, Mitali Kini, Shawn M Davidson, Brian P Fiske, Catherine L Drennan and Matthew G Vander Heiden
    Citation: Cancer & Metabolism 2015 3:5
  3. Mitophagy is a selective form of macro-autophagy in which mitochondria are selectively targeted for degradation in autophagolysosomes. Mitophagy can have the beneficial effect of eliminating old and/or damaged...

    Authors: Aparajita H Chourasia, Michelle L Boland and Kay F Macleod
    Citation: Cancer & Metabolism 2015 3:4
  4. Based on the hypothesis that cancer cells may not be able to metabolize ketones as efficiently as normal brain cells, the ketogenic diet (KD) has been proposed as a complementary or alternative therapy for tre...

    Authors: Kenneth Schwartz, Howard T Chang, Michele Nikolai, Joseph Pernicone, Sherman Rhee, Karl Olson, Peter C Kurniali, Norman G Hord and Mary Noel
    Citation: Cancer & Metabolism 2015 3:3
  5. Hypoxic niches in solid tumors harbor therapy-resistant cells. Hypoxia-activated prodrugs (HAPs) have been designed to overcome this resistance and, to date, have begun to show clinical efficacy. However, clin...

    Authors: Jonathan W Wojtkowiak, Heather C Cornnell, Shingo Matsumoto, Keita Saito, Yoichi Takakusagi, Prasanta Dutta, Munju Kim, Xiaomeng Zhang, Rafael Leos, Kate M Bailey, Gary Martinez, Mark C Lloyd, Craig Weber, James B Mitchell, Ronald M Lynch, Amanda F Baker…
    Citation: Cancer & Metabolism 2015 3:2
  6. Succinate dehydrogenase (SDH) is a mitochondrial metabolic enzyme complex involved in both the electron transport chain and the citric acid cycle. SDH mutations resulting in enzymatic dysfunction have been fou...

    Authors: Paul-Joseph P Aspuria, Sophia Y Lunt, Leif Väremo, Laurent Vergnes, Maricel Gozo, Jessica A Beach, Brenda Salumbides, Karen Reue, W Ruprecht Wiedemeyer, Jens Nielsen, Beth Y Karlan and Sandra Orsulic
    Citation: Cancer & Metabolism 2014 2:21
  7. Cell growth requires fatty acids for membrane synthesis. Fatty acids are assembled from 2-carbon units in the form of acetyl-CoA (AcCoA). In nutrient and oxygen replete conditions, acetyl-CoA is predominantly ...

    Authors: Jurre J Kamphorst, Michelle K Chung, Jing Fan and Joshua D Rabinowitz
    Citation: Cancer & Metabolism 2014 2:23
  8. Here, we present a report of the 2014 annual Beatson International Cancer Conference, Glasgow, July 6–9, 2014. The theme was “Powering the Cancer Machine”, focusing on oncogenic signals that regulate metabolic re...

    Authors: Jurre J Kamphorst and Daniel J Murphy
    Citation: Cancer & Metabolism 2014 2:25

    The Erratum to this article has been published in Cancer & Metabolism 2014 2:127

  9. Mitochondria produce reactive oxygen species (mROS) as a natural by-product of electron transport chain activity. While initial studies focused on the damaging effects of reactive oxygen species, a recent para...

    Authors: Lucas B Sullivan and Navdeep S Chandel
    Citation: Cancer & Metabolism 2014 2:17
  10. Authors: Debarshi Roy, Susmita Mondal, Chen Wang, Xiaoping He, Ashwani Khurana, Shailendra Giri, Robert Hoffmann, Deok-Beom Jung, Sung H Kim, Eduardo N Chini, Juliana Camacho Periera, Clifford D Folmes, Andrea Mariani, Sean C Dowdy, Jamie N Bakkum-Gamez, Shaun M Riska…
    Citation: Cancer & Metabolism 2014 2:24

    The original article was published in Cancer & Metabolism 2014 2:13

  11. Accumulating preclinical and clinical evidence implicates epithelial-mesenchymal transition (EMT) in acquired resistance to anticancer drugs; however, mechanisms by which the mesenchymal state determines drug ...

    Authors: Yuting Sun, Anneleen Daemen, Georgia Hatzivassiliou, David Arnott, Catherine Wilson, Guanglei Zhuang, Min Gao, Peter Liu, Aaron Boudreau, Leisa Johnson and Jeff Settleman
    Citation: Cancer & Metabolism 2014 2:20
  12. It is a well-established scientific observation that mammalian cells contain fidelity proteins that appear to protect against and adapt to various forms of endogenous and exogenous cellular conditions. Loss of...

    Authors: Yueming Zhu, Yufan Yan, Daniel R Principe, Xianghui Zou, Athanassios Vassilopoulos and David Gius
    Citation: Cancer & Metabolism 2014 2:15
  13. In order to solve a jigsaw puzzle, one must first have the complete picture to logically connect the pieces. However, in cancer biology, we are still gaining an understanding of all the signaling pathways that...

    Authors: Rana Elkholi, Thibaud T Renault, Madhavika N Serasinghe and Jerry E Chipuk
    Citation: Cancer & Metabolism 2014 2:16
  14. Macroautophagy (autophagy hereafter) captures and degrades intracellular proteins and organelles in lysosomes as a quality control mechanism and recycles their components to sustain survival in starvation. Cel...

    Authors: Eileen White
    Citation: Cancer & Metabolism 2014 2:14
  15. Aberrant energy metabolism is a hallmark of cancer. To fulfill the increased energy requirements, tumor cells secrete cytokines/factors inducing muscle and fat degradation in cancer patients, a condition known...

    Authors: Surendra K Shukla, Teklab Gebregiworgis, Vinee Purohit, Nina V Chaika, Venugopal Gunda, Prakash Radhakrishnan, Kamiya Mehla, Iraklis I Pipinos, Robert Powers, Fang Yu and Pankaj K Singh
    Citation: Cancer & Metabolism 2014 2:18

    The Erratum to this article has been published in Cancer & Metabolism 2014 2:23

  16. Metformin is widely used in the treatment of diabetes, and there is interest in ‘repurposing’ the drug for cancer prevention or treatment. However, the mechanism underlying the metabolic effects of metformin r...

    Authors: Sylvia Andrzejewski, Simon-Pierre Gravel, Michael Pollak and Julie St-Pierre
    Citation: Cancer & Metabolism 2014 2:12
  17. Loss of the endosulfatase HSulf-1 is common in ovarian cancer, upregulates heparin binding growth factor signaling and potentiates tumorigenesis and angiogenesis. However, metabolic differences between isogeni...

    Authors: Debarshi Roy, Susmita Mondal, Chen Wang, Xiaoping He, Ashwani Khurana, Shailendra Giri, Robert Hoffmann, Deok-Beom Jung, Sung H Kim, Eduardo N Chini, Juliana Camacho Periera, Clifford D Folmes, Andrea Mariani, Sean C Dowdy, Jamie N Bakkum-Gamez, Shaun M Riska…
    Citation: Cancer & Metabolism 2014 2:13

    The Erratum to this article has been published in Cancer & Metabolism 2014 2:24

  18. Alterations in glucose metabolism and epithelial-mesenchymal transition (EMT) constitute two important characteristics of carcinoma progression toward invasive cancer. Despite an extensive characterization of ...

    Authors: Mark Masin, Jessica Vazquez, Simona Rossi, Svenja Groeneveld, Natasha Samson, Petra C Schwalie, Bart Deplancke, Laura E Frawley, Jérôme Gouttenoire, Darius Moradpour, Trudy G Oliver and Etienne Meylan
    Citation: Cancer & Metabolism 2014 2:11
  19. Cancer is a heterogeneous set of diseases characterized by different molecular and cellular features. Over the past decades, researchers have attempted to grasp the complexity of cancer by mapping the genetic ...

    Authors: Edoardo Gaude and Christian Frezza
    Citation: Cancer & Metabolism 2014 2:10
  20. Cellular metabolism is highly dynamic and continuously adjusts to the physiological program of the cell. The regulation of metabolism appears at all biological levels: (post-) transcriptional, (post-) translat...

    Authors: Matthias Pietzke, Christin Zasada, Susann Mudrich and Stefan Kempa
    Citation: Cancer & Metabolism 2014 2:9
  21. Cancer cells, and a variety of normal cells, exhibit aerobic glycolysis, high rates of glucose fermentation in the presence of normal oxygen concentrations, also known as the Warburg effect. This metabolism is...

    Authors: Tamir Epstein, Liping Xu, Robert J Gillies and Robert A Gatenby
    Citation: Cancer & Metabolism 2014 2:7

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