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  1. Content type: Research

    Glutamine metabolism is a central metabolic pathway in cancer. Recently, reductive carboxylation of glutamine for lipogenesis has been shown to constitute a key anabolic route in cancer cells. However, little ...

    Authors: Shawn McGuirk, Simon-Pierre Gravel, Geneviève Deblois, David J Papadopoli, Brandon Faubert, André Wegner, Karsten Hiller, Daina Avizonis, Uri David Akavia, Russell G Jones, Vincent Giguère and Julie St-Pierre

    Citation: Cancer & Metabolism 2013 1:22

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  2. Content type: Research

    Endocrine FGF21 and FGF19 target adipocytes and hepatocytes through betaKlotho (KLB) and FGFR tyrosine kinases effecting glucose, lipid and energy metabolism. Both factors alleviate obesity and metabolic abnor...

    Authors: Yongde Luo, Chaofeng Yang, Min Ye, Chengliu Jin, James L Abbruzzese, Mong-Hong Lee, Sai-Ching J Yeung and Wallace L McKeehan

    Citation: Cancer & Metabolism 2013 1:21

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  3. Content type: Research

    Although cells require nutrients to proliferate, most nutrient exchange rates of the NCI60 panel of cancer cell lines correlate poorly with their proliferation rate. Here, we provide evidence indicating that t...

    Authors: Sonia C Dolfi, Leo Li-Ying Chan, Jean Qiu, Philip M Tedeschi, Joseph R Bertino, Kim M Hirshfield, Zoltán N Oltvai and Alexei Vazquez

    Citation: Cancer & Metabolism 2013 1:20

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  4. Content type: Research

    Most normal cells in the presence of oxygen utilize glucose for mitochondrial oxidative phosphorylation. In contrast, many cancer cells rapidly convert glucose to lactate in the cytosol, a process termed aerob...

    Authors: Julia Billiard, Jennifer B Dennison, Jacques Briand, Roland S Annan, Deping Chai, Mariela Colón, Christopher S Dodson, Seth A Gilbert, Joel Greshock, Junping Jing, Hong Lu, Jeanelle E McSurdy-Freed, Lisa A Orband-Miller, Gordon B Mills, Chad J Quinn, Jessica L Schneck…

    Citation: Cancer & Metabolism 2013 1:19

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  5. Content type: Research

    Germline and somatic mutations in STK11, the gene encoding the serine/threonine kinase LKB1, are strongly associated with tumorigenesis. While loss of LKB1 expression has been linked to breast cancer, the mechani...

    Authors: Fanny Dupuy, Takla Griss, Julianna Blagih, Gäelle Bridon, Daina Avizonis, Chen Ling, Zhifeng Dong, Doris R Siwak, Matthew G Annis, Gordon B Mills, William J Muller, Peter M Siegel and Russell G Jones

    Citation: Cancer & Metabolism 2013 1:18

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  6. Content type: Research

    The Ets-1 proto-oncogene is frequently upregulated in cancer cells, with known involvement in cancer angiogenesis, metastasis, and more recently energy metabolism. In this study we have performed various bioin...

    Authors: Meghan L Verschoor, Chris P Verschoor and Gurmit Singh

    Citation: Cancer & Metabolism 2013 1:17

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  7. Content type: Review

    The resurgence of interest in cancer metabolism has linked alterations in the regulation and exploitation of metabolic pathways with an anabolic phenotype that increases biomass production for the replication ...

    Authors: Jason A Zastre, Rebecca L Sweet, Bradley S Hanberry and Star Ye

    Citation: Cancer & Metabolism 2013 1:16

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  8. Content type: Rapid Communication

    Multiple myeloma (MM) is a fatal plasma cell malignancy exhibiting enhanced glucose consumption associated with an aerobic glycolytic phenotype (i.e., the Warburg effect). We have previously demonstrated that ...

    Authors: Javelin C Cheng, Samuel K McBrayer, Cristian Coarfa, Sevim Dalva-Aydemir, Preethi H Gunaratne, John D Carpten, Jonathan K Keats, Steven T Rosen and Mala Shanmugam

    Citation: Cancer & Metabolism 2013 1:14

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  9. Content type: Research

    Loss of function of fumarate hydratase (FH), the mitochondrial tumor suppressor and tricarboxylic acid (TCA) cycle enzyme, is associated with a highly malignant form of papillary and collecting duct renal cell...

    Authors: Liang Zheng, Elaine D MacKenzie, Saadia A Karim, Ann Hedley, Karen Blyth, Gabriela Kalna, David G Watson, Peter Szlosarek, Christian Frezza and Eyal Gottlieb

    Citation: Cancer & Metabolism 2013 1:12

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  10. Content type: Research

    Aerobic glycolysis, namely the Warburg effect, is the main hallmark of cancer cells. Mitochondrial respiratory dysfunction has been proposed to be one of the major causes for such glycolytic shift. This hypoth...

    Authors: Claudia Calabrese, Luisa Iommarini, Ivana Kurelac, Maria Antonietta Calvaruso, Mariantonietta Capristo, Pier-Luigi Lollini, Patrizia Nanni, Christian Bergamini, Giordano Nicoletti, Carla De Giovanni, Anna Ghelli, Valentina Giorgio, Mariano Francesco Caratozzolo, Flaviana Marzano, Caterina Manzari, Christine M Betts…

    Citation: Cancer & Metabolism 2013 1:11

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  11. Content type: Review

    Calorie restriction (CR) is one of the most potent broadly acting dietary interventions for inducing weight loss and for inhibiting cancer in experimental models. Translation of the mechanistic lessons learned...

    Authors: Stephen D Hursting, Sarah M Dunlap, Nikki A Ford, Marcie J Hursting and Laura M Lashinger

    Citation: Cancer & Metabolism 2013 1:10

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  12. Content type: Rapid Communication

    The p53 tumor suppressor protein is a transcription factor that initiates transcriptional programs aimed at inhibiting carcinogenesis. p53 represses metabolic pathways that support tumor development (such as g...

    Authors: Ido Goldstein, Keren Yizhak, Shalom Madar, Naomi Goldfinger, Eytan Ruppin and Varda Rotter

    Citation: Cancer & Metabolism 2013 1:9

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  13. Content type: Rapid Communication

    Cancer cells engage in aerobic glycolysis and glutaminolysis to fulfill their biosynthetic and energetic demands in part by activating MYC. Previous reports have characterized metabolic changes in proliferating c...

    Authors: Elena Anso, Andrew R Mullen, Dean W Felsher, José M Matés, Ralph J DeBerardinis and Navdeep S Chandel

    Citation: Cancer & Metabolism 2013 1:7

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  14. Content type: Review

    Metabolic reprogramming is a key event in tumorigenesis to support cell growth, and cancer cells frequently become both highly glycolytic and glutamine dependent. Similarly, T lymphocytes (T cells) modify thei...

    Authors: Andrew N Macintyre and Jeffrey C Rathmell

    Citation: Cancer & Metabolism 2013 1:5

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  15. Content type: Methodology

    Tissue imaging of treatment-induced metabolic changes is useful for optimizing cancer therapies, but commonly used methods require trade-offs between assay sensitivity and spatial resolution. Nanostructure-Ini...

    Authors: Peter J O’Brien, Michelle Lee, Mary E Spilker, Cathy C Zhang, Zhengming Yan, Timothy C Nichols, Wenlin Li, Caroline H Johnson, Gary J Patti and Gary Siuzdak

    Citation: Cancer & Metabolism 2013 1:4

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  16. Content type: Research

    Regulation of lipid metabolism via activation of sterol regulatory element binding proteins (SREBPs) has emerged as an important function of the Akt/mTORC1 signaling axis. Although the contribution of dysregul...

    Authors: Beatrice Griffiths, Caroline A Lewis, Karim Bensaad, Susana Ros, Qifeng Zhang, Emma C Ferber, Sofia Konisti, Barrie Peck, Heike Miess, Philip East, Michael Wakelam, Adrian L Harris and Almut Schulze

    Citation: Cancer & Metabolism 2013 1:3

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  17. Content type: Research

    While aerobic glycolysis is linked to unconstrained proliferation in cancer, less is known about its physiological role. Why this metabolic program that promotes tumor growth is preserved in the genome has thu...

    Authors: Timothy R Gershon, Andrew J Crowther, Andrey Tikunov, Idoia Garcia, Ryan Annis, Hong Yuan, C Ryan Miller, Jeffrey Macdonald, James Olson and Mohanish Deshmukh

    Citation: Cancer & Metabolism 2013 1:2

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