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Cancer & Metabolism

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  1. Content type: Research

    Folate-dependent one-carbon metabolism provides one-carbon units for several biological processes. This pathway is highly compartmentalized in eukaryotes, with the mitochondrial pathway producing formate for u...

    Authors: Minhye Shin, Jessica Momb and Dean R. Appling

    Citation: Cancer & Metabolism 2017 5:11

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  2. Content type: Research

    Cancer cells express the M2 isoform of the glycolytic enzyme pyruvate kinase (PKM2). PKM2 expression is not required for some cancers, and PKM2 loss can promote cancer progression; however, PKM2 has been repor...

    Authors: Allison N. Lau, William J. Israelsen, Jatin Roper, Mark J. Sinnamon, Larissa Georgeon, Talya L. Dayton, Alissandra L. Hillis, Omer H. Yilmaz, Dolores Di Vizio, Kenneth E. Hung and Matthew G. Vander Heiden

    Citation: Cancer & Metabolism 2017 5:10

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  3. Content type: Research

    Cancer cells that enter the metastatic cascade require traits that allow them to survive within the circulation and colonize distant organ sites. As disseminating cancer cells adapt to their changing microenvi...

    Authors: Caroline H. Johnson, Antonio F. Santidrian, Sarah E. LeBoeuf, Michael E. Kurczy, Nicholas J. W. Rattray, Zahra Rattray, Benedikt Warth, Melissa Ritland, Linh T. Hoang, Celine Loriot, Jason Higa, James E. Hansen, Brunhilde H. Felding and Gary Siuzdak

    Citation: Cancer & Metabolism 2017 5:9

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  4. Content type: Research

    The proteasome inhibitor bortezomib (BTZ) is successfully applied in the treatment of multiple myeloma, but its efficacy is restricted by the wide-spread occurrence of resistance. Metabolic alterations play an...

    Authors: Esther A. Zaal, Wei Wu, Gerrit Jansen, Sonja Zweegman, Jacqueline Cloos and Celia R. Berkers

    Citation: Cancer & Metabolism 2017 5:7

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  5. Content type: Research

    Among breast cancers, the triple-negative breast cancer (TNBC) subtype has the worst prognosis with no approved targeted therapies and only standard chemotherapy as the backbone of systemic therapy. Unique met...

    Authors: Nathan J. Lanning, Joshua P. Castle, Simar J. Singh, Andre N. Leon, Elizabeth A. Tovar, Amandeep Sanghera, Jeffrey P. MacKeigan, Fabian V. Filipp and Carrie R. Graveel

    Citation: Cancer & Metabolism 2017 5:6

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  6. Content type: Research

    A key feature of clear cell renal cell carcinoma (ccRCC) is the inactivation of the von Hippel-Lindau tumour suppressor protein (pVHL) that leads to the activation of hypoxia-inducible factor (HIF) pathway als...

    Authors: Petra Miikkulainen, Heidi Högel, Krista Rantanen, Tomi Suomi, Petri Kouvonen, Laura L. Elo and Panu M. Jaakkola

    Citation: Cancer & Metabolism 2017 5:5

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  7. Content type: Research

    Ketone bodies have both metabolic and epigenetic roles in cancer. In several studies, they showed an anti-cancer effect via inhibition of histone deacetylases; however, other studies observed faster tumour gro...

    Authors: Loreta M. Rodrigues, Santiago Uribe-Lewis, Basetti Madhu, Davina J. Honess, Marion Stubbs and John R. Griffiths

    Citation: Cancer & Metabolism 2017 5:4

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  8. Content type: Review

    Deregulated metabolism is a well-established hallmark of cancer. At the hub of various metabolic pathways deeply integrated within mitochondrial functions, the α-ketoglutarate dehydrogenase complex represents ...

    Authors: Renaud Vatrinet, Giulia Leone, Monica De Luise, Giulia Girolimetti, Michele Vidone, Giuseppe Gasparre and Anna Maria Porcelli

    Citation: Cancer & Metabolism 2017 5:3

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  9. Content type: Research

    Pancreatic cancer has a five-year survival rate of ~8%, with characteristic molecular heterogeneity and restricted treatment options. Targeting metabolism has emerged as a potentially effective therapeutic str...

    Authors: Rae-Anne Hardie, Ellen van Dam, Mark Cowley, Ting-Li Han, Seher Balaban, Marina Pajic, Mark Pinese, Mary Iconomou, Robert F. Shearer, Jessie McKenna, David Miller, Nicola Waddell, John V. Pearson, Sean M. Grimmond, Leonid Sazanov, Andrew V. Biankin…

    Citation: Cancer & Metabolism 2017 5:2

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  10. Content type: Research

    Obesity is associated with increased recurrence and reduced survival of breast cancer. Adipocytes constitute a significant component of breast tissue, yet their role in provisioning metabolic substrates to sup...

    Authors: Seher Balaban, Robert F. Shearer, Lisa S. Lee, Michelle van Geldermalsen, Mark Schreuder, Harrison C. Shtein, Rose Cairns, Kristen C. Thomas, Daniel J. Fazakerley, Thomas Grewal, Jeff Holst, Darren N. Saunders and Andrew J. Hoy

    Citation: Cancer & Metabolism 2017 5:1

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  11. Content type: Research

    Obesity-related cellular, metabolic, and molecular alterations have been shown to increase cancer risk and tumor progression and are associated with poorer therapeutic outcome in cancer patients. However, the ...

    Authors: Parmanand Malvi, Balkrishna Chaube, Shivendra Vikram Singh, Naoshad Mohammad, Vimal Pandey, Maleppillil Vavachan Vijayakumar, Revathy Meenatheril Radhakrishnan, Muralidharan Vanuopadath, Sudarslal Sadasivan Nair, Bipin Gopalakrishnan Nair and Manoj Kumar Bhat

    Citation: Cancer & Metabolism 2016 4:21

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  12. Content type: Research

    Understanding the biologic mechanisms underlying the development of lethal prostate cancer is critical for improved therapeutic and prevention strategies. In this study we explored the role of tumor metabolism...

    Authors: Rachel S. Kelly, Jennifer A. Sinnott, Jennifer R. Rider, Ericka M. Ebot, Travis Gerke, Michaela Bowden, Andreas Pettersson, Massimo Loda, Howard D. Sesso, Philip W. Kantoff, Neil E. Martin, Edward L. Giovannucci, Svitlana Tyekucheva, Matthew Vander Heiden and Lorelei A. Mucci

    Citation: Cancer & Metabolism 2016 4:22

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  13. Content type: Research

    Pancreatic ductal adenocarcinoma (PDAC) is a common malignancy with dismal prognosis. Metastatic spread and therapeutic resistance, the main causes of PDAC-related mortalities, are both partially underlined by...

    Authors: Menghan Liu, Lake-Ee Quek, Ghazal Sultani and Nigel Turner

    Citation: Cancer & Metabolism 2016 4:19

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  14. Content type: Research

    There is increasing evidence that oncogenic Wnt signaling directs metabolic reprogramming of cancer cells to favor aerobic glycolysis or Warburg metabolism. In colon cancer, this reprogramming is due to direct...

    Authors: Stephanie Sprowl-Tanio, Amber N. Habowski, Kira T. Pate, Miriam M. McQuade, Kehui Wang, Robert A. Edwards, Felix Grun, Yung Lyou and Marian L. Waterman

    Citation: Cancer & Metabolism 2016 4:20

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  15. Content type: Research

    Calorie restriction (CR) prevents obesity and exerts anticancer effects in many preclinical models. CR is also increasingly being used in cancer patients as a sensitizing strategy prior to chemotherapy regimen...

    Authors: Laura M. Lashinger, Ciara H. O’Flanagan, Sarah M. Dunlap, Audrey J. Rasmussen, Shannon Sweeney, Jessie Yangxiang Guo, Alessia Lodi, Stefano Tiziani, Eileen White and Stephen D. Hursting

    Citation: Cancer & Metabolism 2016 4:18

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  16. Content type: Methodology

    Acetyl-CoA is a key metabolic intermediate with roles in the production of energy and biomass, as well as in metabolic regulation. It was recently found that acetate is crucial for maintaining acetyl-CoA produ...

    Authors: Sergey Tumanov, Vinay Bulusu, Eyal Gottlieb and Jurre J. Kamphorst

    Citation: Cancer & Metabolism 2016 4:17

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  17. Content type: Research

    The study of cancer metabolism has been largely dedicated to exploring the hypothesis that oncogenic transformation rewires cellular metabolism to sustain elevated rates of growth and division. Intense examina...

    Authors: Mark A. Keibler, Thomas M. Wasylenko, Joanne K. Kelleher, Othon Iliopoulos, Matthew G. Vander Heiden and Gregory Stephanopoulos

    Citation: Cancer & Metabolism 2016 4:16

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  18. Content type: Research

    The role of anaplerotic nutrient entry into the Krebs cycle via pyruvate carboxylase has been the subject of increased scrutiny and in particular whether this is dysregulated in cancer. Here, we use a tracer-b...

    Authors: Michelle A. C. Reed, Christian Ludwig, Christopher M. Bunce, Farhat L. Khanim and Ulrich L. Günther

    Citation: Cancer & Metabolism 2016 4:15

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  19. Content type: Review

    Molecular profiling studies of tumor tissue from patients with clear cell renal cell cancer (ccRCC) have revealed extensive metabolic reprogramming in this disease. Associations were found between metabolic re...

    Authors: Johannes C. van der Mijn, David J. Panka, Andrew K. Geissler, Henk. M. Verheul and James W. Mier

    Citation: Cancer & Metabolism 2016 4:14

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  20. Content type: Research

    Glucose and glutamine are the two dominant metabolic substrates in cancer cells. In 13C tracer experiments, however, it is necessary to account for all significant input substrates, as some natural (unlabelled) s...

    Authors: Lake-Ee Quek, Menghan Liu, Sanket Joshi and Nigel Turner

    Citation: Cancer & Metabolism 2016 4:13

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  21. Content type: Research

    The heterogeneous biology of breast cancer leads to high diversity in prognosis and response to treatment, even for patients with similar clinical diagnosis, histology, and stage of disease. Identifying mechan...

    Authors: Tonje H. Haukaas, Leslie R. Euceda, Guro F. Giskeødegård, Santosh Lamichhane, Marit Krohn, Sandra Jernström, Miriam R. Aure, Ole C. Lingjærde, Ellen Schlichting, Øystein Garred, Eldri U. Due, Gordon B. Mills, Kristine K. Sahlberg, Anne-Lise Børresen-Dale and Tone F. Bathen

    Citation: Cancer & Metabolism 2016 4:12

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  22. Content type: Research

    Colorectal cancers (CRC) are associated with perturbations in cellular amino acids, nucleotides, pentose-phosphate pathway carbohydrates, and glycolytic, gluconeogenic, and tricarboxylic acid intermediates. A ...

    Authors: Dustin G. Brown, Sangeeta Rao, Tiffany L. Weir, Joanne O’Malia, Marlon Bazan, Regina J. Brown and Elizabeth P. Ryan

    Citation: Cancer & Metabolism 2016 4:11

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  23. Content type: Research

    Gleason scores (GS) 3+3 and 3+4 prostate cancers (PCa) differ greatly in their clinical courses, with Gleason pattern (GP) 4 representing a major independent risk factor for cancer progression. However, Gleaso...

    Authors: Ilinca Georgescu, Robert J. Gooding, R. Christopher Doiron, Andrew Day, Shamini Selvarajah, Chris Davidson, David M. Berman and Paul C. Park

    Citation: Cancer & Metabolism 2016 4:8

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  24. Content type: Research

    The majority of cancer cells have a unique metabolic requirement for methionine that is not observed in normal, non-tumorigenic cells. This phenotype is described as “methionine dependence” or “methionine stre...

    Authors: Stacey L. Borrego, Johannes Fahrmann, Rupsa Datta, Chiara Stringari, Dmitry Grapov, Michael Zeller, Yumay Chen, Ping Wang, Pierre Baldi, Enrico Gratton, Oliver Fiehn and Peter Kaiser

    Citation: Cancer & Metabolism 2016 4:9

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