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  1. Kidney cancer is a common adult malignancy in the USA. Clear cell renal cell carcinoma (ccRCC), the predominant subtype of kidney cancer, is characterized by widespread metabolic changes. Urea metabolism is on...

    Authors: Sanika Khare, Laura C. Kim, Graham Lobel, Paschalis-Thomas Doulias, Harry Ischiropoulos, Itzhak Nissim, Brian Keith and M. Celeste Simon

    Citation: Cancer & Metabolism 2021 9:40

    Content type: Research

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  2. Pyruvate dehydrogenase complex (PDC) plays a central role in carbohydrate metabolism, linking cytoplasmic glycolysis to the mitochondrial tricarboxylic acid (TCA) cycle. PDC is a conserved E1-E2-E3 dehydrogena...

    Authors: Nancy P. Echeverri Ruiz, Vijay Mohan, Jinghai Wu, Sabina Scott, McKenzie Kreamer, Martin Benej, Tereza Golias, Ioanna Papandreou and Nicholas C. Denko

    Citation: Cancer & Metabolism 2021 9:39

    Content type: Research

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  3. Excessive lactate production, a hallmark of cancer, is largely formed by the reduction of pyruvate via lactate dehydrogenase (LDH) to l-lactate. Although d-lactate can also be produced from glucose via the methyl...

    Authors: Eul Hyun Suh, Carlos F. G. C. Geraldes, Sara Chirayil, Brandon Faubert, Raul Ayala, Ralph J. DeBerardinis and A. Dean Sherry

    Citation: Cancer & Metabolism 2021 9:38

    Content type: Research

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  4. Triple negative breast cancer (TNBC) poses a serious clinical challenge as it is an aggressive form of the disease that lacks estrogen receptor, progesterone receptor, and ERBB2 (formerly HER2) gene amplificat...

    Authors: Irini Skaripa-Koukelli, David Hauton, John Walsby-Tickle, Eloïse Thomas, Joshua Owen, Abirami Lakshminarayanan, Sarah Able, James McCullagh, Robert C. Carlisle and Katherine A. Vallis

    Citation: Cancer & Metabolism 2021 9:37

    Content type: Research

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  5. Enhanced metabolic plasticity and diversification of energy production is a hallmark of highly proliferative breast cancers. This contributes to poor pharmacotherapy efficacy, recurrence, and metastases. We ha...

    Authors: Elizabeth R. M. Zunica, Christopher L. Axelrod, Eunhan Cho, Guillaume Spielmann, Gangarao Davuluri, Stephanie J. Alexopoulos, Martina Beretta, Kyle L. Hoehn, Wagner S. Dantas, Krisztian Stadler, William T. King, Kathryn Pergola, Brian A. Irving, Ingeborg M. Langohr, Shengping Yang, Charles L. Hoppel…

    Citation: Cancer & Metabolism 2021 9:36

    Content type: Research

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  6. Patient-derived bulk expression profiles of cancers can provide insight into the transcriptional changes that underlie reprogrammed metabolism in cancer. These profiles represent the average expression pattern...

    Authors: V. C. Leeuwenburgh, C. G. Urzúa-Traslaviña, A. Bhattacharya, M. T. C. Walvoort, M. Jalving, S. de Jong and R. S. N. Fehrmann

    Citation: Cancer & Metabolism 2021 9:35

    Content type: Research

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  7. Metabolite genome-wide association studies (mGWAS) are key for understanding the genetic regulation of metabolites in complex diseases including cancers. Although mGWAS has revealed hundreds of metabolomics qu...

    Authors: Shuangfeng Yang, Yuan-Liang Wang, Yanping Lyu, Yu Jiang, Jianjun Xiang, Shumi Ji, Shuling Kang, Xuejie Lyu, Chenzhou He, Peixin Li, Baoying Liu and Chuancheng Wu

    Citation: Cancer & Metabolism 2021 9:34

    Content type: Research

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  8. The transcription factor MYC is overexpressed in 30% of small cell lung cancer (SCLC) tumors and is known to modulate the balance between two major pathways of metabolism: glycolysis and mitochondrial respirat...

    Authors: Kasey R. Cargill, C. Allison Stewart, Elizabeth M. Park, Kavya Ramkumar, Carl M. Gay, Robert J. Cardnell, Qi Wang, Lixia Diao, Li Shen, You-Hong Fan, Wai Kin Chan, Philip L. Lorenzi, Trudy G. Oliver, Jing Wang and Lauren A. Byers

    Citation: Cancer & Metabolism 2021 9:33

    Content type: Research

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  9. Recent studies suggest that fructose, as well as its metabolite, uric acid, have been associated with increased risk for both cancer incidence and growth. Both substances are known to cause oxidative stress to...

    Authors: Mehdi A. Fini, Miguel A. Lanaspa, Eric A. Gaucher, Brian Boutwell, Takahiko Nakagawa, Richard M. Wright, Laura G. Sanchez-Lozada, Peter Andrews, Kurt R. Stenmark and Richard J. Johnson

    Citation: Cancer & Metabolism 2021 9:32

    Content type: Short Report

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  10. Metabolic reprogramming is a central feature in many cancer subtypes and a hallmark of cancer. Many therapeutic strategies attempt to exploit this feature, often having unintended side effects on normal metabo...

    Authors: Daniel F. Liefwalker, Meital Ryan, Zhichao Wang, Khyatiben V. Pathak, Seema Plaisier, Vidhi Shah, Bobby Babra, Gabrielle S. Dewson, Ian K. Lai, Adriane R. Mosley, Patrick T. Fueger, Stephanie C. Casey, Lei Jiang, Patrick Pirrotte, Srividya Swaminathan and Rosalie C. Sears

    Citation: Cancer & Metabolism 2021 9:31

    Content type: Research

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  11. Cholangiocarcioma (CCA) treatment is challenging because most of the patients are diagnosed when the disease is advanced, and cancer recurrence is the main problem after treatment, leading to low survival rate...

    Authors: Sureerat Padthaisong, Jutarop Phetcharaburanin, Poramate Klanrit, Jia V. Li, Nisana Namwat, Narong Khuntikeo, Attapol Titapun, Apiwat Jarearnrat, Arporn Wangwiwatsin, Panupong Mahalapbutr and Watcharin Loilome

    Citation: Cancer & Metabolism 2021 9:30

    Content type: Research

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  12. Men with African ancestry are more likely to develop aggressive prostate cancer (PCa) and to die from this disease. The study of PCa in the South African population represents an opportunity for biomedical res...

    Authors: Stefano Cacciatore, Martha Wium, Cristina Licari, Aderonke Ajayi-Smith, Lorenzo Masieri, Chanelle Anderson, Azola Samkele Salukazana, Lisa Kaestner, Marco Carini, Giuseppina M. Carbone, Carlo V. Catapano, Massimo Loda, Towia A. Libermann and Luiz F. Zerbini

    Citation: Cancer & Metabolism 2021 9:29

    Content type: Research

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  13. Arginine (Arg) is essential for cancer cell growth and also for the activation of T cells. Thus, therapies aiming to reduce Arg utilization by cancer may prove detrimental for the immune response.

    Authors: Alexandra Giatromanolaki, Adrian L. Harris and Michael I. Koukourakis

    Citation: Cancer & Metabolism 2021 9:28

    Content type: Short Report

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  14. Reprogramming of metabolic pathways is crucial to satisfy the bioenergetic and biosynthetic demands and maintain the redox status of rapidly proliferating cancer cells. In tumors, the tricarboxylic acid (TCA) ...

    Authors: Sunada Khadka, Kenisha Arthur, Yasaman Barekatain, Eliot Behr, Mykia Washington, Jeffrey Ackroyd, Kaitlyn Crowley, Pornpa Suriyamongkol, Yu-Hsi Lin, Cong-Dat Pham, Rafal Zielinski, Marissa Trujillo, James Galligan, Dimitra K. Georgiou, John Asara and Florian Muller

    Citation: Cancer & Metabolism 2021 9:27

    Content type: Research

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  15. Metabolic reprogramming is a common phenomenon in tumorigenesis and tumor progression. Amino acids are important mediators in cancer metabolism, and their kinetics in tumor tissue are far from being understood...

    Authors: Jianhua Cao, Benjamin Balluff, Martijn Arts, Ludwig J. Dubois, Luc J. C. van Loon, Tilman M. Hackeng, Hans M. H. van Eijk, Gert Eijkel, Lara R. Heij, Zita Soons, Steven W. M. Olde Damink and Ron M. A. Heeren

    Citation: Cancer & Metabolism 2021 9:26

    Content type: Rapid communication

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  16. There are limited evidences clarifying the impact of metabolic syndrome (MS) and its components on head and neck cancer (HNC) incidence risk. We explored the correlation between MS, MS components, and the comb...

    Authors: Huaili Jiang, Lei Zhou, Qiangsheng He, Kanglun Jiang, Jinqiu Yuan and Xinsheng Huang

    Citation: Cancer & Metabolism 2021 9:25

    Content type: Research

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  17. Neuroblastoma accounts for 7% of paediatric malignancies but is responsible for 15% of all childhood cancer deaths. Despite rigorous treatment involving chemotherapy, surgery, radiotherapy and immunotherapy, t...

    Authors: Donna L. Nile, Colin Rae, David J. Walker, Joe Canning Waddington, Isabel Vincent, Karl Burgess, Mark N. Gaze, Robert J. Mairs and Anthony J. Chalmers

    Citation: Cancer & Metabolism 2021 9:24

    Content type: Research

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  18. Cancer cell is generally characterized by enhanced glycolysis. Inflammasome activation is interaction with glycolysis. The concentration of lipopolysaccharide (LPS), a classic inflammasome activator, is signif...

    Authors: Xuesong Wu, Senmi Qian, Jun Zhang, Jieqiong Feng, Ke Luo, Lichao Sun, Liang Zhao, Yuliang Ran, Liang Sun, Jing Wang and Fangying Xu

    Citation: Cancer & Metabolism 2021 9:23

    Content type: Research

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  19. Human dihydroorotate dehydrogenase (DHODH) is a flavin-dependent mitochondrial enzyme catalyzing the fourth step in the de novo pyrimidine synthesis pathway. It is originally a target for the treatment of the ...

    Authors: Yue Zhou, Lei Tao, Xia Zhou, Zeping Zuo, Jin Gong, Xiaocong Liu, Yang Zhou, Chunqi Liu, Na Sang, Huan Liu, Jiao Zou, Kun Gou, Xiaowei Yang and Yinglan Zhao

    Citation: Cancer & Metabolism 2021 9:22

    Content type: Review

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  20. pO2 and pH are physiological parameters relevant for different processes in health and disease, including wound healing and cancer progression. Head and neck squamous cell carcinomas (HNSCC) and oesophageal squam...

    Authors: Alexandra Blancke Soares, Robert Meier, Gregor Liebsch, Sabina Schwenk-Zieger, Martin E. Kirmaier, Sebastian Theurich, Magdalena Widmann, Martin Canis, Olivier Gires and Frank Haubner

    Citation: Cancer & Metabolism 2021 9:21

    Content type: Research

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  21. Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate (OAA), serving to replenish the tricarboxylic acid (TCA) cycle. In nonmalignant ti...

    Authors: Violet A. Kiesel, Madeline P. Sheeley, Michael F. Coleman, Eylem Kulkoyluoglu Cotul, Shawn S. Donkin, Stephen D. Hursting, Michael K. Wendt and Dorothy Teegarden

    Citation: Cancer & Metabolism 2021 9:20

    Content type: Review

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  22. Tumor necrosis factor-α (TNF-α) is an immunostimulatory cytokine that is consistently high in the breast tumor microenvironment (TME); however, its differential role in mitochondrial functions and cell surviva...

    Authors: Anjali Shinde, Hyeryeon Jung, Hayun Lee, Kritarth Singh, Milton Roy, Dhruv Gohel, Han Byeol Kim, Minal Mane, Hitesh Vasiyani, Fatema Currim, Yu Ri Seo, Seojin Yang, Ara Cho, Eugene C. Yi and Rajesh Singh

    Citation: Cancer & Metabolism 2021 9:19

    Content type: Research

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  23. Glioblastoma is the most frequent and high-grade adult malignant central nervous system tumor. The prognosis is still poor despite the use of combined therapy involving maximal surgical resection, radiotherapy...

    Authors: Yollanda E. Moreira Franco, Maria Jose Alves, Miyuki Uno, Isabele Fattori Moretti, Marina Trombetta-Lima, Suzana de Siqueira Santos, Ancely Ferreira dos Santos, Gabriel Santos Arini, Mauricio S. Baptista, Antonio Marcondes Lerario, Sueli Mieko Oba-Shinjo and Suely Kazue Nagahashi Marie

    Citation: Cancer & Metabolism 2021 9:18

    Content type: Research

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  24. Highly proliferating cancer cells exhibit the Warburg effect by regulation of PKM alternative splicing and promoting the expression of PKM2. Majority of the alternative splicing events are known to occur in the n...

    Authors: Arpankumar Choksi, Apoorva Parulekar, Richa Pant, Vibhuti Kumar Shah, Ramakrishna Nimma, Priyanka Firmal, Smriti Singh, Gopal C. Kundu, Sanjeev Shukla and Samit Chattopadhyay

    Citation: Cancer & Metabolism 2021 9:16

    Content type: Research

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  25. Visceral fat produces several hormones and cytokines associated with carcinogenesis and tumor progression. Herein, we investigated the association between visceral adiposity and target-gene mRNA expression in ...

    Authors: Jee Soo Park, Won Sik Jang, Jongchan Kim, Seung Hwan Lee, Koon Ho Rha and Won Sik Ham

    Citation: Cancer & Metabolism 2021 9:15

    Content type: Research

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  26. Cancer cells drastically increase the uptake of glucose and glucose metabolism by overexpressing class I glucose transporters (GLUT1-4) to meet their energy and biomass synthesis needs and are very sensitive a...

    Authors: Pratik Shriwas, Dennis Roberts, Yunsheng Li, Liyi Wang, Yanrong Qian, Stephen Bergmeier, Jennifer Hines, Subhodip Adhicary, Corinne Nielsen and Xiaozhuo Chen

    Citation: Cancer & Metabolism 2021 9:14

    Content type: Research

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  27. Majority of chondrosarcomas are associated with a number of genetic alterations, including somatic mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 genes, but the downstream effects of these mutated enzyme...

    Authors: Sinthu Pathmanapan, Olga Ilkayeva, John T. Martin, Adrian Kwan Ho Loe, Hongyuan Zhang, Guo-Fang Zhang, Christopher B. Newgard, Jay S. Wunder and Benjamin A. Alman

    Citation: Cancer & Metabolism 2021 9:13

    Content type: Research

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  28. Fructose is an abundant source of carbon and energy for cells to use for metabolism, but only certain cell types use fructose to proliferate. Tumor cells that acquire the ability to metabolize fructose have a ...

    Authors: Roger J. Liang, Samuel Taylor, Navid Nahiyaan, Junho Song, Charles J. Murphy, Ezequiel Dantas, Shuyuan Cheng, Ting-Wei Hsu, Shakti Ramsamooj, Rahul Grover, Seo-Kyoung Hwang, Bryan Ngo, Lewis C. Cantley, Kyu Y. Rhee and Marcus D. Goncalves

    Citation: Cancer & Metabolism 2021 9:12

    Content type: Research

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  29. Sulfasalazine (SSZ) is widely known as an xCT inhibitor suppressing CD44v9-expressed cancer stem-like cells (CSCs) being related to redox regulation. Cholangiocarcinoma (CCA) has a high recurrence rate and no ...

    Authors: Malinee Thanee, Sureerat Padthaisong, Manida Suksawat, Hasaya Dokduang, Jutarop Phetcharaburanin, Poramate Klanrit, Attapol Titapun, Nisana Namwat, Arporn Wangwiwatsin, Prakasit Sa-ngiamwibool, Narong Khuntikeo, Hideyuki Saya and Watcharin Loilome

    Citation: Cancer & Metabolism 2021 9:11

    Content type: Research

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  30. Harnessing the power of the immune system by using immune checkpoint inhibitors has resulted in some of the most exciting advances in cancer treatment. The full potential of this approach has, however, not bee...

    Authors: Jesus Pacheco-Torres, Marie-France Penet, Yelena Mironchik, Balaji Krishnamachary and Zaver M. Bhujwalla

    Citation: Cancer & Metabolism 2021 9:10

    Content type: Research

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  31. Prostate cancer tissues are inherently heterogeneous, which presents a challenge for metabolic profiling using traditional bulk analysis methods that produce an averaged profile. The aim of this study was ther...

    Authors: Maria K. Andersen, Therese S. Høiem, Britt S. R. Claes, Benjamin Balluff, Marta Martin-Lorenzo, Elin Richardsen, Sebastian Krossa, Helena Bertilsson, Ron M. A. Heeren, Morten B. Rye, Guro F. Giskeødegård, Tone F. Bathen and May-Britt Tessem

    Citation: Cancer & Metabolism 2021 9:9

    Content type: Research

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  32. This study aimed to evaluate the prognostic value of pretreatment 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in patients with localized primary gastrointestinal strom...

    Authors: Sang Hyun Hwang, Minkyu Jung, Yong Hyu Jeong, KwanHyeong Jo, Soyoung Kim, Jiyoung Wang and Arthur Cho

    Citation: Cancer & Metabolism 2021 9:8

    Content type: Research

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  33. Patients with lung adenocarcinoma (LUAD) have high mortality rate and poor prognosis. The LUAD cells display increased aerobic glycolysis, which generates energy required for their survival and proliferation. ...

    Authors: Xiao-Ting Wu, Yu-Han Wang, Xiao-Yue Cai, Yun Dong, Qing Cui, Ya-Ning Zhou, Xi-Wen Yang, Wen-Feng Lu and Ming Zhang

    Citation: Cancer & Metabolism 2021 9:7

    Content type: Research

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  34. Sirtuin 6 (SIRT6) is a NAD+-dependent deacetylase with key roles in cell metabolism. High SIRT6 expression is associated with adverse prognosis in breast cancer (BC) patients. However, the mechanisms through whic...

    Authors: Pamela Becherini, Irene Caffa, Francesco Piacente, Patrizia Damonte, Valerio G. Vellone, Mario Passalacqua, Andrea Benzi, Tommaso Bonfiglio, Daniele Reverberi, Amr Khalifa, Moustafa Ghanem, Ana Guijarro, Luca Tagliafico, Marzia Sucameli, Angelica Persia, Fiammetta Monacelli…

    Citation: Cancer & Metabolism 2021 9:6

    Content type: Research

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  35. Aerobic glycolysis, discovered by Otto Warburg, is a hallmark of cancer metabolism even though not yet fully understood. The low activity of the cancerous pyruvate kinase isozyme (M2) is thought to play an imp...

    Authors: Fadi Almouhanna, Biljana Blagojevic, Suzan Can, Ali Ghanem and Stefan Wölfl

    Citation: Cancer & Metabolism 2021 9:5

    Content type: Research

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  36. Many cancers silence the metabolic enzyme argininosuccinate synthetase 1 (ASS1), the rate-limiting enzyme for arginine biosynthesis within the urea cycle. Consequently, ASS1-negative cells are susceptible to d...

    Authors: Leonard C. Rogers, Jing Zhou, Adriana Baker, Charles R. Schutt, Prashanta K. Panda and Brian A. Van Tine

    Citation: Cancer & Metabolism 2021 9:4

    Content type: Research

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  37. Hepatocellular carcinoma (HCC) is the most prevalent form of liver malignancy and carries poor prognoses due to late presentation of symptoms. Treatment of late-stage HCC relies heavily on chemotherapeutics, m...

    Authors: Cameron A. Schmidt, Kelsey L. McLaughlin, Ilya N. Boykov, Rafiq Mojalagbe, Arthi Ranganathan, Katherine A. Buddo, Chien-Te Lin, Kelsey H. Fisher-Wellman and P. Darrell Neufer

    Citation: Cancer & Metabolism 2021 9:3

    Content type: Research

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  38. Tumor cellular metabolism exhibits distinguishing features that collectively enhance biomass synthesis while maintaining redox balance and cellular homeostasis. These attributes reflect the complex interaction...

    Authors: Shilpa R. Nagarajan, Lisa M. Butler and Andrew J. Hoy

    Citation: Cancer & Metabolism 2021 9:2

    Content type: Review

    Published on:

  39. Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M; PCK2) is expressed in all cancer types examined and in neuroprogenitor cells. The gene is upregulated by amino acid limitation and ER-stress in an ATF4...

    Authors: Petra Hyroššová, Marc Aragó, Juan Moreno-Felici, Xiarong Fu, Andrés Mendez-Lucas, Pablo M. García-Rovés, Shawn Burgess, Agnès Figueras, Francesc Viñals and Jose C. Perales

    Citation: Cancer & Metabolism 2021 9:1

    Content type: Research

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  40. Overexpression of c-Myc is required for the progression of pre-malignant plasma cells in monoclonal gammopathy of undetermined significance (MGUS) to malignant plasma cells in multiple myeloma (MM). c-Myc also...

    Authors: Wilson I. Gonsalves, Jin Sung Jang, Erik Jessen, Taro Hitosugi, Laura A. Evans, Dragan Jevremovic, Xuan-Mai Pettersson, Alexander Graham Bush, Jaimee Gransee, Emilie I. Anderson, Shaji K. Kumar and K. Sreekumaran Nair

    Citation: Cancer & Metabolism 2020 8:29

    Content type: Research

    Published on:

  41. Of the genes that control mitochondrial biogenesis and function, ERRα emerges as a druggable metabolic target to be exploited for cancer therapy. Of the genes mutated in cancer, TP53 remains the most elusive to t...

    Authors: Humberto De Vitto, Joohyun Ryu, Ali Calderon-Aparicio, Josh Monts, Raja Dey, Abhijit Chakraborty, Mee-Hyun Lee, Ann M. Bode and Zigang Dong

    Citation: Cancer & Metabolism 2020 8:28

    Content type: Research

    Published on:

  42. Protein synthesis is regulated by the availability of amino acids, the engagement of growth factor signaling pathways, and adenosine triphosphate (ATP) levels sufficient to support translation. Crosstalk betwe...

    Authors: Blake R. Wilde, Mohan R. Kaadige, Katrin P. Guillen, Andrew Butterfield, Bryan E. Welm and Donald E. Ayer

    Citation: Cancer & Metabolism 2020 8:27

    Content type: Research

    Published on:

  43. Aspartate biosynthesis and its delivery to the cytosol can be crucial for tumor growth in vivo. However, the impact of intracellular aspartate levels on metastasis has not been studied. We previously described th...

    Authors: H. Furkan Alkan, Paul W. Vesely, Hubert Hackl, Johannes Foßelteder, Daniel R. Schmidt, Matthew G. Vander Heiden, Martin Pichler, Gerald Hoefler and Juliane G. Bogner-Strauss

    Citation: Cancer & Metabolism 2020 8:26

    Content type: Short Report

    Published on:

  44. Deregulated lipid metabolism is common in cancer cells and the mevalonate pathway, which synthesizes cholesterol, is central in lipid metabolism. This study aimed to assess statin-induced changes of the intrat...

    Authors: Maria Feldt, Julien Menard, Ann H. Rosendahl, Barbara Lettiero, Pär-Ola Bendahl, Mattias Belting and Signe Borgquist

    Citation: Cancer & Metabolism 2020 8:25

    Content type: Research

    Published on:

  45. Glioblastoma (GBM) has poor survival with standard treatment. Experimental data suggest potential for metabolic treatment with low carbohydrate ketogenic diet (KD). Few human studies of KD in GBM have been don...

    Authors: Pavel Klein, Ivana Tyrlikova, Giulio Zuccoli, Adam Tyrlik and Joseph C. Maroon

    Citation: Cancer & Metabolism 2020 8:24

    Content type: Research

    Published on:

  46. Targeting glutamine metabolism in cancer has become an increasingly vibrant area of research. Mutant IDH1 (IDH1mut) gliomas are considered good candidates for targeting this pathway because of the contribution of...

    Authors: Victor Ruiz-Rodado, Adrian Lita, Tyrone Dowdy, Orieta Celiku, Alejandra Cavazos Saldana, Herui Wang, Chun Zhang Yang, Raj Chari, Aiguo Li, Wei Zhang, Hua Song, Meili Zhang, Susie Ahn, Dionne Davis, Xiang Chen, Zhengping Zhuang…

    Citation: Cancer & Metabolism 2020 8:23

    Content type: Research

    Published on:

  47. Rewiring of metabolism induced by oncogenic K-Ras in cancer cells involves both glucose and glutamine utilization sustaining enhanced, unrestricted growth. The development of effective anti-cancer treatments targ...

    Authors: Daniela Gaglio, Marcella Bonanomi, Silvia Valtorta, Rohit Bharat, Marilena Ripamonti, Federica Conte, Giulia Fiscon, Nicole Righi, Elisabetta Napodano, Federico Papa, Isabella Raccagni, Seth J. Parker, Ingrid Cifola, Tania Camboni, Paola Paci, Anna Maria Colangelo…

    Citation: Cancer & Metabolism 2020 8:22

    Content type: Research

    Published on:

  48. Overweight or obesity has been evidenced as an important risk factor involved in the incidence, mortality, and therapy response of multiple malignancies. However, the differences between healthy and obesity tu...

    Authors: Chao Hu, Xiong Chen, Chengyun Yao, Yu Liu, Haojun Xu, Guoren Zhou, Hongping Xia and Jinglin Xia

    Citation: Cancer & Metabolism 2020 8:21

    Content type: Research

    Published on:

  49. Mitochondrial serine catabolism to formate induces a metabolic switch to a hypermetabolic state with high rates of glycolysis, purine synthesis and pyrimidine synthesis. While formate is a purine precursor, it...

    Authors: Jacqueline Tait-Mulder, Kelly Hodge, David Sumpton, Sara Zanivan and Alexei Vazquez

    Citation: Cancer & Metabolism 2020 8:20

    Content type: Research

    Published on:

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