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  1. Breast cancer (BC) is the most commonly diagnosed cancer. Currently, mammography and breast ultrasonography are the main clinical screening methods for BC. Our study aimed to reveal the specific metabolic prof...

    Authors: Rui An, Haitao Yu, Yanzhong Wang, Jie Lu, Yuzhen Gao, Xinyou Xie and Jun Zhang
    Citation: Cancer & Metabolism 2022 10:13
  2. Growing evidence supports the use of low-carbohydrate/high-fat ketogenic diets as an adjunctive cancer therapy. However, it is unclear which genetic, metabolic, or immunological factors contribute to the benef...

    Authors: Daniela D. Weber, Sepideh Aminzadeh-Gohari, Maheshwor Thapa, Anna-Sophia Redtenbacher, Luca Catalano, Tânia Capelôa, Thibaut Vazeille, Michael Emberger, Thomas K. Felder, René G. Feichtinger, Peter Koelblinger, Guido Dallmann, Pierre Sonveaux, Roland Lang and Barbara Kofler
    Citation: Cancer & Metabolism 2022 10:12
  3. 13C tracer analysis is increasingly used to monitor cellular metabolism in vivo and in intact cells, but data interpretation is still the key element to unveil the complexity of metabolic activities. The distinct...

    Authors: Likun Duan, Daniel E. Cooper, Grace Scheidemantle, Jason W. Locasale, David G. Kirsch and Xiaojing Liu
    Citation: Cancer & Metabolism 2022 10:11
  4. Metabolic adaptations can allow cancer cells to survive DNA-damaging chemotherapy. This unmet clinical challenge is a potential vulnerability of cancer. Accordingly, there is an intense search for mechanisms t...

    Authors: Christian Marx, Jürgen Sonnemann, Oliver D. K. Maddocks, Lisa Marx-Blümel, Mandy Beyer, Doerte Hoelzer, René Thierbach, Claudia Maletzki, Michael Linnebacher, Thorsten Heinzel and Oliver H. Krämer
    Citation: Cancer & Metabolism 2022 10:10
  5. Most in vitro cancer cell experiments have been performed using 2D models. However, 3D spheroid cultures are increasingly favored for being more representative of in vivo tumor conditions. To overcome the tran...

    Authors: Tia R. Tidwell, Gro V. Røsland, Karl Johan Tronstad, Kjetil Søreide and Hanne R. Hagland
    Citation: Cancer & Metabolism 2022 10:9
  6. Although iron chelation has garnered attention as a novel therapeutic strategy for cancer, higher levels of efficacy need to be achieved. In the present study, we examined the combinatorial effect of deferoxam...

    Authors: Koichi Fujisawa, Taro Takami, Toshihiko Matsumoto, Naoki Yamamoto, Takahiro Yamasaki and Isao Sakaida
    Citation: Cancer & Metabolism 2022 10:8
  7. Hepatocellular carcinoma (HCC) is the predominant form of liver cancer and is accompanied by complex dysregulation of lipids. Increasing evidence suggests that particular lipid species are associated with HCC ...

    Authors: Jerry D. Monroe, Daniel Fraher, Xiaoqian Huang, Natalie A. Mellett, Peter J. Meikle, Andrew J. Sinclair, Seth T. Lirette, Nita J. Maihle, Zhiyuan Gong and Yann Gibert
    Citation: Cancer & Metabolism 2022 10:7
  8. Primary and posttreatment resistance to BRAFV600 mutation–targeting inhibitors leads to disease relapse in a majority of melanoma patients. In many instances, this resistance is promoted by upregulation of mitoch...

    Authors: Evelyn de Groot, Sruthy Varghese, Lin Tan, Barbara Knighton, Mary Sobieski, Nghi Nguyen, Yong Sung Park, Reid Powell, Philip L. Lorenzi, Bin Zheng, Clifford Stephan and Y. N. Vashisht Gopal
    Citation: Cancer & Metabolism 2022 10:6
  9. Hyperinsulinemia is independently associated with increased risk and mortality of pancreatic cancer. We recently reported that genetically reduced insulin production resulted in ~ 50% suppression of pancreatic...

    Authors: Anni M. Y. Zhang, Ken H. Chu, Brian F. Daly, Titine Ruiter, Yan Dou, Jenny C. C. Yang, Twan J. J. de Winter, Justin Chhuor, Su Wang, Stephane Flibotte, Yiwei Bernie Zhao, Xiaoke Hu, Hong Li, Elizabeth J. Rideout, David F. Schaeffer, James D. Johnson…
    Citation: Cancer & Metabolism 2022 10:5
  10. Deregulated glucose metabolism is a critical component of cancer growth and survival, clinically evident via FDG-PET imaging of enhanced glucose uptake in tumor nodules. Tumor cells utilize glucose in a variet...

    Authors: Jason Godfrey, Romain Riscal, Nicolas Skuli and M. Celeste Simon
    Citation: Cancer & Metabolism 2022 10:4
  11. Hypoxia in the tumor microenvironment (TME) is often the main factor in the cancer progression. Moreover, low levels of oxygen in tumor tissue may signal that the first- or second-line therapy will not be succ...

    Authors: Miriam Zatovicova, Ivana Kajanova, Monika Barathova, Martina Takacova, Martina Labudova, Lucia Csaderova, Lenka Jelenska, Eliska Svastova, Silvia Pastorekova, Adrian L. Harris and Jaromir Pastorek
    Citation: Cancer & Metabolism 2022 10:3
  12. Altered lipid metabolism is closely related to the occurrence and development of hepatocellular carcinoma (HCC). Carnitine palmitoyltransferase 1C (CPT1C) is a member of CPT1 family and plays a key role in can...

    Authors: Ting Zhang, Yanan Zhang, Jie Liu, Yan Ma, Qinong Ye, Xinlong Yan and Lihua Ding
    Citation: Cancer & Metabolism 2022 10:2
  13. Prostate cancer growth is driven by androgen receptor signaling, and advanced disease is initially treatable by depleting circulating androgens. However, prostate cancer cells inevitably adapt, resulting in di...

    Authors: Nikki L. Raftopulos, Tinashe C. Washaya, Andreas Niederprüm, Antonia Egert, Mariam F. Hakeem-Sanni, Bianca Varney, Atqiya Aishah, Mariya L. Georgieva, Ellinor Olsson, Diandra Z. dos Santos, Zeyad D. Nassar, Blake J. Cochran, Shilpa R. Nagarajan, Meghna S. Kakani, Jordan F. Hastings, David R. Croucher…
    Citation: Cancer & Metabolism 2022 10:1
  14. Hexokinases (HKs) are well-studied enzymes catalyzing the first step of glycolysis. However, non-canonical regulatory roles of HKs are still incompletely understood. Here, we hypothesized that HKs comprise one...

    Authors: Daniela Šimčíková, Dominik Gardáš, Kateřina Hložková, Martin Hruda, Petr Žáček, Lukáš Rob and Petr Heneberg
    Citation: Cancer & Metabolism 2021 9:41
  15. Kidney cancer is a common adult malignancy in the USA. Clear cell renal cell carcinoma (ccRCC), the predominant subtype of kidney cancer, is characterized by widespread metabolic changes. Urea metabolism is on...

    Authors: Sanika Khare, Laura C. Kim, Graham Lobel, Paschalis-Thomas Doulias, Harry Ischiropoulos, Itzhak Nissim, Brian Keith and M. Celeste Simon
    Citation: Cancer & Metabolism 2021 9:40
  16. Pyruvate dehydrogenase complex (PDC) plays a central role in carbohydrate metabolism, linking cytoplasmic glycolysis to the mitochondrial tricarboxylic acid (TCA) cycle. PDC is a conserved E1-E2-E3 dehydrogena...

    Authors: Nancy P. Echeverri Ruiz, Vijay Mohan, Jinghai Wu, Sabina Scott, McKenzie Kreamer, Martin Benej, Tereza Golias, Ioanna Papandreou and Nicholas C. Denko
    Citation: Cancer & Metabolism 2021 9:39
  17. Excessive lactate production, a hallmark of cancer, is largely formed by the reduction of pyruvate via lactate dehydrogenase (LDH) to l-lactate. Although d-lactate can also be produced from glucose via the methyl...

    Authors: Eul Hyun Suh, Carlos F. G. C. Geraldes, Sara Chirayil, Brandon Faubert, Raul Ayala, Ralph J. DeBerardinis and A. Dean Sherry
    Citation: Cancer & Metabolism 2021 9:38
  18. Triple negative breast cancer (TNBC) poses a serious clinical challenge as it is an aggressive form of the disease that lacks estrogen receptor, progesterone receptor, and ERBB2 (formerly HER2) gene amplificat...

    Authors: Irini Skaripa-Koukelli, David Hauton, John Walsby-Tickle, Eloïse Thomas, Joshua Owen, Abirami Lakshminarayanan, Sarah Able, James McCullagh, Robert C. Carlisle and Katherine A. Vallis
    Citation: Cancer & Metabolism 2021 9:37
  19. Enhanced metabolic plasticity and diversification of energy production is a hallmark of highly proliferative breast cancers. This contributes to poor pharmacotherapy efficacy, recurrence, and metastases. We ha...

    Authors: Elizabeth R. M. Zunica, Christopher L. Axelrod, Eunhan Cho, Guillaume Spielmann, Gangarao Davuluri, Stephanie J. Alexopoulos, Martina Beretta, Kyle L. Hoehn, Wagner S. Dantas, Krisztian Stadler, William T. King, Kathryn Pergola, Brian A. Irving, Ingeborg M. Langohr, Shengping Yang, Charles L. Hoppel…
    Citation: Cancer & Metabolism 2021 9:36
  20. Patient-derived bulk expression profiles of cancers can provide insight into the transcriptional changes that underlie reprogrammed metabolism in cancer. These profiles represent the average expression pattern...

    Authors: V. C. Leeuwenburgh, C. G. Urzúa-Traslaviña, A. Bhattacharya, M. T. C. Walvoort, M. Jalving, S. de Jong and R. S. N. Fehrmann
    Citation: Cancer & Metabolism 2021 9:35
  21. Metabolite genome-wide association studies (mGWAS) are key for understanding the genetic regulation of metabolites in complex diseases including cancers. Although mGWAS has revealed hundreds of metabolomics qu...

    Authors: Shuangfeng Yang, Yuan-Liang Wang, Yanping Lyu, Yu Jiang, Jianjun Xiang, Shumi Ji, Shuling Kang, Xuejie Lyu, Chenzhou He, Peixin Li, Baoying Liu and Chuancheng Wu
    Citation: Cancer & Metabolism 2021 9:34
  22. The transcription factor MYC is overexpressed in 30% of small cell lung cancer (SCLC) tumors and is known to modulate the balance between two major pathways of metabolism: glycolysis and mitochondrial respirat...

    Authors: Kasey R. Cargill, C. Allison Stewart, Elizabeth M. Park, Kavya Ramkumar, Carl M. Gay, Robert J. Cardnell, Qi Wang, Lixia Diao, Li Shen, You-Hong Fan, Wai Kin Chan, Philip L. Lorenzi, Trudy G. Oliver, Jing Wang and Lauren A. Byers
    Citation: Cancer & Metabolism 2021 9:33
  23. Recent studies suggest that fructose, as well as its metabolite, uric acid, have been associated with increased risk for both cancer incidence and growth. Both substances are known to cause oxidative stress to...

    Authors: Mehdi A. Fini, Miguel A. Lanaspa, Eric A. Gaucher, Brian Boutwell, Takahiko Nakagawa, Richard M. Wright, Laura G. Sanchez-Lozada, Peter Andrews, Kurt R. Stenmark and Richard J. Johnson
    Citation: Cancer & Metabolism 2021 9:32
  24. Metabolic reprogramming is a central feature in many cancer subtypes and a hallmark of cancer. Many therapeutic strategies attempt to exploit this feature, often having unintended side effects on normal metabo...

    Authors: Daniel F. Liefwalker, Meital Ryan, Zhichao Wang, Khyatiben V. Pathak, Seema Plaisier, Vidhi Shah, Bobby Babra, Gabrielle S. Dewson, Ian K. Lai, Adriane R. Mosley, Patrick T. Fueger, Stephanie C. Casey, Lei Jiang, Patrick Pirrotte, Srividya Swaminathan and Rosalie C. Sears
    Citation: Cancer & Metabolism 2021 9:31
  25. Cholangiocarcioma (CCA) treatment is challenging because most of the patients are diagnosed when the disease is advanced, and cancer recurrence is the main problem after treatment, leading to low survival rate...

    Authors: Sureerat Padthaisong, Jutarop Phetcharaburanin, Poramate Klanrit, Jia V. Li, Nisana Namwat, Narong Khuntikeo, Attapol Titapun, Apiwat Jarearnrat, Arporn Wangwiwatsin, Panupong Mahalapbutr and Watcharin Loilome
    Citation: Cancer & Metabolism 2021 9:30
  26. Men with African ancestry are more likely to develop aggressive prostate cancer (PCa) and to die from this disease. The study of PCa in the South African population represents an opportunity for biomedical res...

    Authors: Stefano Cacciatore, Martha Wium, Cristina Licari, Aderonke Ajayi-Smith, Lorenzo Masieri, Chanelle Anderson, Azola Samkele Salukazana, Lisa Kaestner, Marco Carini, Giuseppina M. Carbone, Carlo V. Catapano, Massimo Loda, Towia A. Libermann and Luiz F. Zerbini
    Citation: Cancer & Metabolism 2021 9:29
  27. Arginine (Arg) is essential for cancer cell growth and also for the activation of T cells. Thus, therapies aiming to reduce Arg utilization by cancer may prove detrimental for the immune response.

    Authors: Alexandra Giatromanolaki, Adrian L. Harris and Michael I. Koukourakis
    Citation: Cancer & Metabolism 2021 9:28
  28. Reprogramming of metabolic pathways is crucial to satisfy the bioenergetic and biosynthetic demands and maintain the redox status of rapidly proliferating cancer cells. In tumors, the tricarboxylic acid (TCA) ...

    Authors: Sunada Khadka, Kenisha Arthur, Yasaman Barekatain, Eliot Behr, Mykia Washington, Jeffrey Ackroyd, Kaitlyn Crowley, Pornpa Suriyamongkol, Yu-Hsi Lin, Cong-Dat Pham, Rafal Zielinski, Marissa Trujillo, James Galligan, Dimitra K. Georgiou, John Asara and Florian Muller
    Citation: Cancer & Metabolism 2021 9:27
  29. Metabolic reprogramming is a common phenomenon in tumorigenesis and tumor progression. Amino acids are important mediators in cancer metabolism, and their kinetics in tumor tissue are far from being understood...

    Authors: Jianhua Cao, Benjamin Balluff, Martijn Arts, Ludwig J. Dubois, Luc J. C. van Loon, Tilman M. Hackeng, Hans M. H. van Eijk, Gert Eijkel, Lara R. Heij, Zita Soons, Steven W. M. Olde Damink and Ron M. A. Heeren
    Citation: Cancer & Metabolism 2021 9:26
  30. There are limited evidences clarifying the impact of metabolic syndrome (MS) and its components on head and neck cancer (HNC) incidence risk. We explored the correlation between MS, MS components, and the comb...

    Authors: Huaili Jiang, Lei Zhou, Qiangsheng He, Kanglun Jiang, Jinqiu Yuan and Xinsheng Huang
    Citation: Cancer & Metabolism 2021 9:25
  31. Neuroblastoma accounts for 7% of paediatric malignancies but is responsible for 15% of all childhood cancer deaths. Despite rigorous treatment involving chemotherapy, surgery, radiotherapy and immunotherapy, t...

    Authors: Donna L. Nile, Colin Rae, David J. Walker, Joe Canning Waddington, Isabel Vincent, Karl Burgess, Mark N. Gaze, Robert J. Mairs and Anthony J. Chalmers
    Citation: Cancer & Metabolism 2021 9:24
  32. Cancer cell is generally characterized by enhanced glycolysis. Inflammasome activation is interaction with glycolysis. The concentration of lipopolysaccharide (LPS), a classic inflammasome activator, is signif...

    Authors: Xuesong Wu, Senmi Qian, Jun Zhang, Jieqiong Feng, Ke Luo, Lichao Sun, Liang Zhao, Yuliang Ran, Liang Sun, Jing Wang and Fangying Xu
    Citation: Cancer & Metabolism 2021 9:23
  33. Human dihydroorotate dehydrogenase (DHODH) is a flavin-dependent mitochondrial enzyme catalyzing the fourth step in the de novo pyrimidine synthesis pathway. It is originally a target for the treatment of the ...

    Authors: Yue Zhou, Lei Tao, Xia Zhou, Zeping Zuo, Jin Gong, Xiaocong Liu, Yang Zhou, Chunqi Liu, Na Sang, Huan Liu, Jiao Zou, Kun Gou, Xiaowei Yang and Yinglan Zhao
    Citation: Cancer & Metabolism 2021 9:22
  34. pO2 and pH are physiological parameters relevant for different processes in health and disease, including wound healing and cancer progression. Head and neck squamous cell carcinomas (HNSCC) and oesophageal squam...

    Authors: Alexandra Blancke Soares, Robert Meier, Gregor Liebsch, Sabina Schwenk-Zieger, Martin E. Kirmaier, Sebastian Theurich, Magdalena Widmann, Martin Canis, Olivier Gires and Frank Haubner
    Citation: Cancer & Metabolism 2021 9:21
  35. Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate (OAA), serving to replenish the tricarboxylic acid (TCA) cycle. In nonmalignant ti...

    Authors: Violet A. Kiesel, Madeline P. Sheeley, Michael F. Coleman, Eylem Kulkoyluoglu Cotul, Shawn S. Donkin, Stephen D. Hursting, Michael K. Wendt and Dorothy Teegarden
    Citation: Cancer & Metabolism 2021 9:20
  36. Tumor necrosis factor-α (TNF-α) is an immunostimulatory cytokine that is consistently high in the breast tumor microenvironment (TME); however, its differential role in mitochondrial functions and cell surviva...

    Authors: Anjali Shinde, Hyeryeon Jung, Hayun Lee, Kritarth Singh, Milton Roy, Dhruv Gohel, Han Byeol Kim, Minal Mane, Hitesh Vasiyani, Fatema Currim, Yu Ri Seo, Seojin Yang, Ara Cho, Eugene C. Yi and Rajesh Singh
    Citation: Cancer & Metabolism 2021 9:19
  37. Glioblastoma is the most frequent and high-grade adult malignant central nervous system tumor. The prognosis is still poor despite the use of combined therapy involving maximal surgical resection, radiotherapy...

    Authors: Yollanda E. Moreira Franco, Maria Jose Alves, Miyuki Uno, Isabele Fattori Moretti, Marina Trombetta-Lima, Suzana de Siqueira Santos, Ancely Ferreira dos Santos, Gabriel Santos Arini, Mauricio S. Baptista, Antonio Marcondes Lerario, Sueli Mieko Oba-Shinjo and Suely Kazue Nagahashi Marie
    Citation: Cancer & Metabolism 2021 9:18
  38. Highly proliferating cancer cells exhibit the Warburg effect by regulation of PKM alternative splicing and promoting the expression of PKM2. Majority of the alternative splicing events are known to occur in the n...

    Authors: Arpankumar Choksi, Apoorva Parulekar, Richa Pant, Vibhuti Kumar Shah, Ramakrishna Nimma, Priyanka Firmal, Smriti Singh, Gopal C. Kundu, Sanjeev Shukla and Samit Chattopadhyay
    Citation: Cancer & Metabolism 2021 9:16
  39. Visceral fat produces several hormones and cytokines associated with carcinogenesis and tumor progression. Herein, we investigated the association between visceral adiposity and target-gene mRNA expression in ...

    Authors: Jee Soo Park, Won Sik Jang, Jongchan Kim, Seung Hwan Lee, Koon Ho Rha and Won Sik Ham
    Citation: Cancer & Metabolism 2021 9:15
  40. Cancer cells drastically increase the uptake of glucose and glucose metabolism by overexpressing class I glucose transporters (GLUT1-4) to meet their energy and biomass synthesis needs and are very sensitive a...

    Authors: Pratik Shriwas, Dennis Roberts, Yunsheng Li, Liyi Wang, Yanrong Qian, Stephen Bergmeier, Jennifer Hines, Subhodip Adhicary, Corinne Nielsen and Xiaozhuo Chen
    Citation: Cancer & Metabolism 2021 9:14
  41. Majority of chondrosarcomas are associated with a number of genetic alterations, including somatic mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 genes, but the downstream effects of these mutated enzyme...

    Authors: Sinthu Pathmanapan, Olga Ilkayeva, John T. Martin, Adrian Kwan Ho Loe, Hongyuan Zhang, Guo-Fang Zhang, Christopher B. Newgard, Jay S. Wunder and Benjamin A. Alman
    Citation: Cancer & Metabolism 2021 9:13
  42. Fructose is an abundant source of carbon and energy for cells to use for metabolism, but only certain cell types use fructose to proliferate. Tumor cells that acquire the ability to metabolize fructose have a ...

    Authors: Roger J. Liang, Samuel Taylor, Navid Nahiyaan, Junho Song, Charles J. Murphy, Ezequiel Dantas, Shuyuan Cheng, Ting-Wei Hsu, Shakti Ramsamooj, Rahul Grover, Seo-Kyoung Hwang, Bryan Ngo, Lewis C. Cantley, Kyu Y. Rhee and Marcus D. Goncalves
    Citation: Cancer & Metabolism 2021 9:12
  43. Sulfasalazine (SSZ) is widely known as an xCT inhibitor suppressing CD44v9-expressed cancer stem-like cells (CSCs) being related to redox regulation. Cholangiocarcinoma (CCA) has a high recurrence rate and no ...

    Authors: Malinee Thanee, Sureerat Padthaisong, Manida Suksawat, Hasaya Dokduang, Jutarop Phetcharaburanin, Poramate Klanrit, Attapol Titapun, Nisana Namwat, Arporn Wangwiwatsin, Prakasit Sa-ngiamwibool, Narong Khuntikeo, Hideyuki Saya and Watcharin Loilome
    Citation: Cancer & Metabolism 2021 9:11
  44. Harnessing the power of the immune system by using immune checkpoint inhibitors has resulted in some of the most exciting advances in cancer treatment. The full potential of this approach has, however, not bee...

    Authors: Jesus Pacheco-Torres, Marie-France Penet, Yelena Mironchik, Balaji Krishnamachary and Zaver M. Bhujwalla
    Citation: Cancer & Metabolism 2021 9:10
  45. Prostate cancer tissues are inherently heterogeneous, which presents a challenge for metabolic profiling using traditional bulk analysis methods that produce an averaged profile. The aim of this study was ther...

    Authors: Maria K. Andersen, Therese S. Høiem, Britt S. R. Claes, Benjamin Balluff, Marta Martin-Lorenzo, Elin Richardsen, Sebastian Krossa, Helena Bertilsson, Ron M. A. Heeren, Morten B. Rye, Guro F. Giskeødegård, Tone F. Bathen and May-Britt Tessem
    Citation: Cancer & Metabolism 2021 9:9
  46. This study aimed to evaluate the prognostic value of pretreatment 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in patients with localized primary gastrointestinal strom...

    Authors: Sang Hyun Hwang, Minkyu Jung, Yong Hyu Jeong, KwanHyeong Jo, Soyoung Kim, Jiyoung Wang and Arthur Cho
    Citation: Cancer & Metabolism 2021 9:8
  47. Patients with lung adenocarcinoma (LUAD) have high mortality rate and poor prognosis. The LUAD cells display increased aerobic glycolysis, which generates energy required for their survival and proliferation. ...

    Authors: Xiao-Ting Wu, Yu-Han Wang, Xiao-Yue Cai, Yun Dong, Qing Cui, Ya-Ning Zhou, Xi-Wen Yang, Wen-Feng Lu and Ming Zhang
    Citation: Cancer & Metabolism 2021 9:7
  48. Sirtuin 6 (SIRT6) is a NAD+-dependent deacetylase with key roles in cell metabolism. High SIRT6 expression is associated with adverse prognosis in breast cancer (BC) patients. However, the mechanisms through whic...

    Authors: Pamela Becherini, Irene Caffa, Francesco Piacente, Patrizia Damonte, Valerio G. Vellone, Mario Passalacqua, Andrea Benzi, Tommaso Bonfiglio, Daniele Reverberi, Amr Khalifa, Moustafa Ghanem, Ana Guijarro, Luca Tagliafico, Marzia Sucameli, Angelica Persia, Fiammetta Monacelli…
    Citation: Cancer & Metabolism 2021 9:6
  49. Aerobic glycolysis, discovered by Otto Warburg, is a hallmark of cancer metabolism even though not yet fully understood. The low activity of the cancerous pyruvate kinase isozyme (M2) is thought to play an imp...

    Authors: Fadi Almouhanna, Biljana Blagojevic, Suzan Can, Ali Ghanem and Stefan Wölfl
    Citation: Cancer & Metabolism 2021 9:5

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