Volume 2 Supplement 1

Metabolism, Diet and Disease 2014: Cancer and metabolism

Meeting abstracts

This supplement has not been supported by sponsorship.

Metabolism, Diet and Disease 2014: Cancer and metabolism. Go to conference site.

Washington DC, USA28-30 May 2014

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Metabolic heterogeneity in cancer

Authors: Ralph J DeBerardinis

Citation: Cancer & Metabolism 2014 2(Suppl 1):O1

Content type: Oral presentation Published on: 28 May 2014
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Metabolic analysis of the loss of Rb1 in vivo

Authors: Brandon N Nicolay, Paul S Danielian, Wilhelm Haas, Gregory Stephanopoulos, Jacqueline A Lees and Nicholas J Dyson

Citation: Cancer & Metabolism 2014 2(Suppl 1):O4

Content type: Oral presentation Published on: 28 May 2014
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Fructose-2,6-bisphosphate links glucose to survival and growth

Authors: Abdullah Yalcin, Yoannis Imbert-Fernandez, Amy Clem, Julie O’Neal, Sucheta Telang, Brian Clem and Jason Chesney

Citation: Cancer & Metabolism 2014 2(Suppl 1):O5

Content type: Oral presentation Published on: 28 May 2014
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Nutrition and metabolic factors in cancer causation and prevention

Authors: Elio Riboli

Citation: Cancer & Metabolism 2014 2(Suppl 1):O6

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A hypothetical means of treating or preventing cancer

Authors: Steven L McKnight

Citation: Cancer & Metabolism 2014 2(Suppl 1):O7

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Oncogenic switching of hypoxia signalling pathways

Authors: Peter J Ratcliffe

Citation: Cancer & Metabolism 2014 2(Suppl 1):O8

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Acetyl-coA synthetase 2 promotes acetate utilization and maintains cell growth under metabolic stress

Authors: Zachary Schug, Barrie Peck, Dylan Jones, Qifeng Zhang, Israt Alam, Tim Witney, Elizabeth Smethurst, Shaun Grosskurth, Adrian Harris, Susan Critchlow, Eric Aboagye, Michael Wakelam, Almut Schulze and Eyal Gottlieb

Citation: Cancer & Metabolism 2014 2(Suppl 1):O9

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Antagonistic effects of MYC and hypoxia in channeling glucose and glutamine into de novo nucleotide biosynthesis

Authors: Teresa Fan, Anne Le, Zachary Stine, Ye Yang, Karen Zeller, Weiqiang Zhou, Hongkai Ji, Richard Higashi, Chi Dang and Andrew Lane

Citation: Cancer & Metabolism 2014 2(Suppl 1):O10

Content type: Oral presentation Published on: 28 May 2014
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Role of autophagy in K-RAS- and B-RAF-driven lung cancers

Authors: Eileen White

Citation: Cancer & Metabolism 2014 2(Suppl 1):O11

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The mitochondrial pyruvate carrier as a mediator of the Warburg Effect and its impact on cancer growth and metabolism

Authors: John Schell, Kristofor Olson and Jared Rutter

Citation: Cancer & Metabolism 2014 2(Suppl 1):O14

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AMPK – roles in nutrient sensing and in cancer

Authors: D Grahame Hardie

Citation: Cancer & Metabolism 2014 2(Suppl 1):O16

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Regulation of metabolism by a neuroendocrine FGF signaling pathway

Authors: David J Mangelsdorf and Steven A Kliewer

Citation: Cancer & Metabolism 2014 2(Suppl 1):O17

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Loss of SIRT3 leads to a compensatory shift in cellular metabolism promoting cancer cell growth

Authors: Eoin McDonnell, Olga R Ilkayeva, Robert D Stevens, Michael J Muehlbauer, James R Bain, Tomas C Becker and Matthew D Hirschey

Citation: Cancer & Metabolism 2014 2(Suppl 1):O18

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A Drosophila model linking diet-induced metabolic disease and cancer

Authors: Susumu Hirabayashi, Thomas Baranski and Ross Cagan

Citation: Cancer & Metabolism 2014 2(Suppl 1):O19

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Regulation of growth and metabolism

Authors: David M Sabatini

Citation: Cancer & Metabolism 2014 2(Suppl 1):O20

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The high colon cancer risk in African Americans can be reduced by dietary modification

Authors: Stephen O’Keefe

Citation: Cancer & Metabolism 2014 2(Suppl 1):O22

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AMPK regulated metabolic programing: oncogenic or growth suppressive? Evolving lessons from genetic and pharmacologic studies

Authors: Xiaona Liu, Rishi Raj Chhipa, Lionel ML Chow, Matthew Wortman, Christopher McPherson, Ady Kendler and Biplab Dasgupta

Citation: Cancer & Metabolism 2014 2(Suppl 1):O23

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Metformin targets the GTPase Rac1 to inhibit prostate cancer cell migration

Authors: Béatrice Dirat, Isabelle Ader, Muriel Golzio, Amel Mettouchi, Kathiane Laurent, Frédéric Larbret, Bernard Malavaud, Mireille Cormont, Emmanuel Lemichez, Jean François Tanti and Frédéric Bost

Citation: Cancer & Metabolism 2014 2(Suppl 1):O24

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Biguanide therapy for diabetes and cancer & a novel methyltransferase that regulates energy expenditure and adiposity and is elevated in many cancers

Authors: Barbara B Kahn, Daniel Kraus and Qin Yang

Citation: Cancer & Metabolism 2014 2(Suppl 1):O25

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Energy balance at the organism and cellular level: effects of biguanides

Authors: Michael Pollak

Citation: Cancer & Metabolism 2014 2(Suppl 1):O26

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Metformin, mitochondria and cancer

Authors: Navdeep S Chandel

Citation: Cancer & Metabolism 2014 2(Suppl 1):O27

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Effects of biguanides on oxidative phosphorylation

Authors: Judy Hirst

Citation: Cancer & Metabolism 2014 2(Suppl 1):O28

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PI 3-kinase and disease

Authors: Lewis C Cantley

Citation: Cancer & Metabolism 2014 2(Suppl 1):O30

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Can inhibiting insulin/IGF signaling with dietary carbohydrate restriction play a role in treatment/prevention of cancers?

Authors: Eugene J Fine, C Segal-Isaacson, Silvia Herzkopf, Joseph Sparano, Maria Romano, Richard Feinman, Nora Tomuta, Amanda Bontempo and Abdissa Negassa

Citation: Cancer & Metabolism 2014 2(Suppl 1):O31

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What cancer is teaching us about cellular metabolism

Authors: Craig B Thompson

Citation: Cancer & Metabolism 2014 2(Suppl 1):O32

Content type: Oral presentation Published on: 28 May 2014
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A metabolic map of hematopoietic stem cells

Authors: Michalis Agathocleous, Zeping Hu and Sean Morrison

Citation: Cancer & Metabolism 2014 2(Suppl 1):P1

Content type: Poster presentation Published on: 28 May 2014
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Doxorubicin leads to impaired insulin signaling in skeletal muscle

Authors: Edson Alves de Lima Junior, Camila Oliveira de Souza, Alexandre Abílio de Souza Teixeira, Helena Angélica Batatinha, Fábio de Santos Lira and José César Rosa Neto

Citation: Cancer & Metabolism 2014 2(Suppl 1):P2

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Dual mode of action of metformin on mitochondrial metabolism

Authors: Sylvia Andrzejewski, Simon-Pierre Gravel, Julie St-Pierre and Michael N Pollak

Citation: Cancer & Metabolism 2014 2(Suppl 1):P4

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Adipose tissue homeostasis is deeply disrupted by doxorubicin treatment

Authors: Helena Batatinha, Camila Souza, Edson Lima, Maria Isabel Alonso-Vale, Maysa Cruz, Roberta Da Cunha, Fabio Lira and Jose Rosa

Citation: Cancer & Metabolism 2014 2(Suppl 1):P5

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mTORC1 stimulates nucleotide synthesis through both transcriptional and post-translational mechanisms

Authors: Issam Ben-Sahra, Stephane Ricoult, Jessica Howell, John Asara and Brendan Manning

Citation: Cancer & Metabolism 2014 2(Suppl 1):P6

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Profiling metabolic changes in breast cancer with targeted proteomics

Authors: Stephan Bernhardt, Devina Mitra, Zita Soons, Rainer König, Martina Vetter, Christoph Thomssen, Eva Kantelhardt, Stefan Wiemann and Ulrike Korf

Citation: Cancer & Metabolism 2014 2(Suppl 1):P7

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¹H Nuclear magnetic resonance based targeted profiling of metabolic responses induced by DNA damaging agents and PARP inhibition in MCF-7 cells

Authors: Vijesh Bhute, Daniel Beard, Stephen Kron and Sean Palecek

Citation: Cancer & Metabolism 2014 2(Suppl 1):P8

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Dichloroacetate is an effective treatment for sarcoma models in vitro and in vivo

Authors: Melissa Rooke, Lucy A Coupland, Thy Truong and Anneke C Blackburn

Citation: Cancer & Metabolism 2014 2(Suppl 1):P9

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Chemoprevention with the metabolism modifying drugs dichloroacetate and metformin in the Li-Fraumeni Syndrome model, Trp53^+/- mice

Authors: Anneke C Blackburn, Melissa Rooke, Yiming Li, Jane E Dahlstrom and Philip G Board

Citation: Cancer & Metabolism 2014 2(Suppl 1):P10

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Biochemical and biophysical characterization of pyruvate kinase M2 activation by L-serine

Authors: Barbara Chaneton, Finn Holding, Adam Hold, Jiska Van Der Reest, Gabriele Marciano, Marc O’Reilly and Eyal Gottlieb

Citation: Cancer & Metabolism 2014 2(Suppl 1):P12

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Metabolic diversity in human non-small cell lung cancer

Authors: Pei-Hsuan Chen, Ling Cai, Hyun Seok Kim, Rebecca Britt, Guanghua Xiao, Michael A White, John D Minna and Ralph J DeBerardinis

Citation: Cancer & Metabolism 2014 2(Suppl 1):P13

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Discovery of a PFKFB3 inhibitor for phase I trial testing that synergizes with the B-Raf inhibitor vemurafenib

Authors: Sucheta Telang, Julie O’Neal, Gilles Tapolsky, Brian Clem, Alan Kerr, Yoannis Imbert-Ferndandez and Jason Chesney

Citation: Cancer & Metabolism 2014 2(Suppl 1):P14

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The in vivo function of TIGAR, a p53 target gene that regulates glucose metabolism

Authors: Eric Cheung, Pearl Lee, Celia Berkers, Karen Blyth, Owen Sansom and Karen Vousden

Citation: Cancer & Metabolism 2014 2(Suppl 1):P15

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Inhibiting glucose-regulated protein 78 modulates lipid metabolism through controlling stearoyl-CoA desaturase 1

Authors: Katherine Cook, Pamela Clarke, Anni Warri and Robert Clarke

Citation: Cancer & Metabolism 2014 2(Suppl 1):P16

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Altered cancer cell metabolism and cachexia: Calculating the energetic cost of cancer

Authors: Douglas Friesen, Vickie Baracos and Jack Tuszynski

Citation: Cancer & Metabolism 2014 2(Suppl 1):P18

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Effects of the ghrelin receptor agonist anamorelin on lean body mass in cancer patients with cachexia; results from a Phase II randomized, double blind, multicenter study

Authors: Jose M Garcia, Ying Yan, Elizabeth Manning-Duus and John Friend

Citation: Cancer & Metabolism 2014 2(Suppl 1):P19

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Investigation of the role of Ras and other signaling kinases on the regulation of pyruvate dehydrogenase complex activity

Authors: Antonio Garcia-Trinidad, Nicky Whalley and Susan Critchlow

Citation: Cancer & Metabolism 2014 2(Suppl 1):P20

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Extracts from medicinal plants inhibit cancer cell proliferation, induce apoptosis in ovary, lung and neuronal cancer cell lines

Authors: Wafa Ghali, David Vaudry, Thierry Jouenne and Mohamed Nejib Marzouki

Citation: Cancer & Metabolism 2014 2(Suppl 1):P21

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Metformin suppresses pediatric acute myeloid leukemia cell viability and clonogenicity

Authors: Anilkumar Gopalakrishnapillai, E Anders Kolb and Sonali Barwe

Citation: Cancer & Metabolism 2014 2(Suppl 1):P23

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Chemosensitization of leukemia cells through inhibition of NAMPT

Authors: Theresa Gorski, Stefanie Petzold-Quinque, Susanne Schuster, Melanie Penke, Sandy Richter, Wieland Kiess and Antje Garten

Citation: Cancer & Metabolism 2014 2(Suppl 1):P24

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Influence of polyphenol-rich apple pomace extract on oxidative damage to DNA in type 2 diabetes mellitus individuals

Authors: Annemarie Grindel, Elisabeth Müllner, Helmut Brath, Walther Jäger, Trine Henriksen, Henrik Enghusen Poulsen, Doris Marko and Karl-Heinz Wagner

Citation: Cancer & Metabolism 2014 2(Suppl 1):P25

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Radiation-induction of MMPs limited the NK-mediated anticancer immunity in lung cancer cells

Authors: Woong Heo, Young Shin Lee, Cheol Hun Son, Kwang Mo Yang, You Soo Park and Jae Ho Bae

Citation: Cancer & Metabolism 2014 2(Suppl 1):P26

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Inhibition of glutamine uptake regulates mTORC1, glutamine metabolism and cell growth in prostate cancer

Authors: Qian Wang, Rae-Anne Hardie, Seher Balaban, Mark Schreuder, Andrew Hoy, Michelle van Geldermalsen, Ladan Fazli, Rajini Nagarajah, Charles Bailey, John Rasko and Jeff Holst

Citation: Cancer & Metabolism 2014 2(Suppl 1):P27

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Mechanisms and consequences of hepatic regulation of mTORC1 by metformin

Authors: Jessica J Howell, Kristina Hellberg, Reuben J Shaw and Brendan D Manning

Citation: Cancer & Metabolism 2014 2(Suppl 1):P28

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Simultaneous inhibition of the estrogen receptor and 6-phosphofructo-2-kinase (PFKFB3) for the treatment of ER+ breast cancer

Authors: Yoannis Imbert-Fernandez, Sucheta Telang and Jason Chesney

Citation: Cancer & Metabolism 2014 2(Suppl 1):P29

Content type: Poster presentation Published on: 28 May 2014
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Metabolism, Diet and Disease 2014: Cancer and metabolism

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