Bosi E: Metformin–the gold standard in type 2 diabetes: what does the evidence tell us?. Diabetes Obes Metab. 2009, 11 (Suppl 2): 3-8.
Article
CAS
PubMed
Google Scholar
Campbell RK, White JR, Saulie BA: Metformin: a new oral biguanide. Clin Ther. 1996, 18: 360-371. 10.1016/S0149-2918(96)80017-8. discussion 359
Article
CAS
PubMed
Google Scholar
Turner RC: The U.K. Prospective diabetes study. A review. Diabetes Care. 1998, 21 (Suppl 3): C35-C38.
Article
PubMed
Google Scholar
Evans JM, Donnelly LA, Emslie-Smith AM, Alessi DR, Morris AD: Metformin and reduced risk of cancer in diabetic patients. BMJ. 2005, 330: 1304-1305. 10.1136/bmj.38415.708634.F7.
Article
PubMed
PubMed Central
Google Scholar
Giovannucci E, Harlan DM, Archer MC, Bergenstal RM, Gapstur SM, Habel LA, Pollak M, Regensteiner JG, Yee D: Diabetes and cancer: a consensus report. CA Cancer J Clin. 2010, 60: 207-221. 10.3322/caac.20078.
Article
PubMed
Google Scholar
Ben Sahra I, Laurent K, Loubat A, Giorgetti-Peraldi S, Colosetti P, Auberger P, Tanti JF, Le Marchand-Brustel Y, Bost F: The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level. Oncogene. 2008, 27: 3576-3586. 10.1038/sj.onc.1211024.
Article
CAS
PubMed
Google Scholar
Zakikhani M, Dowling R, Fantus IG, Sonenberg N, Pollak M: Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells. Cancer Res. 2006, 66: 10269-10273. 10.1158/0008-5472.CAN-06-1500.
Article
CAS
PubMed
Google Scholar
Pollak M: Potential applications for biguanides in oncology. J Clin Invest. 2013, 123: 3693-3700. 10.1172/JCI67232.
Article
CAS
PubMed
PubMed Central
Google Scholar
El-Mir MY, Nogueira V, Fontaine E, Averet N, Rigoulet M, Leverve X: Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I. J Biol Chem. 2000, 275: 223-228. 10.1074/jbc.275.1.223.
Article
CAS
PubMed
Google Scholar
Falcone AB, Mao RL, Shrago E: A study of the action of hypoglycemia-producing biguanide and sulfonylurea compounds on oxidative phosphorylation. J Biol Chem. 1962, 237: 904-909.
CAS
PubMed
Google Scholar
Liu X, Chhipa RR, Pooya S, Wortman M, Yachyshin S, Chow LM, Kumar A, Zhou X, Sun Y, Quinn B, McPherson C, VVarnick RE, Kendler A, Girl S, Poels J, Norga K, Viollet B, Grabowski GA, Dasgupta B: Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK. Proc Natl Acad Sci U S A. 2014, 111: E435-E444. 10.1073/pnas.1311121111.
Article
CAS
PubMed
PubMed Central
Google Scholar
Logie L, Harthill J, Patel K, Bacon S, Hamilton DL, Macrae K, McDougall G, Wang HH, Xue L, Jiang H, Sakamoto K, Prescott AR, Rena G: Cellular responses to the metal-binding properties of metformin. Diabetes. 2012, 61: 1423-1433. 10.2337/db11-0961.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ouyang J, Parakhia RA, Ochs RS: Metformin activates AMP kinase through inhibition of AMP deaminase. J Biol Chem. 2011, 286: 1-11. 10.1074/jbc.M110.121806.
Article
CAS
PubMed
PubMed Central
Google Scholar
Owen MR, Doran E, Halestrap AP: Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochem J. 2000, 348 (Pt 3): 607-614.
Article
CAS
PubMed
PubMed Central
Google Scholar
Repiscak P, Erhardt S, Rena G, Paterson MJ: Biomolecular mode of action of metformin in relation to its copper binding properties. Biochemistry. 2014, 53: 787-795. 10.1021/bi401444n.
Article
CAS
PubMed
Google Scholar
Birsoy K, Possemato R, Lorbeer FK, Bayraktar EC, Thiru P, Yucel B, Wang T, Chen WW, Clish CB, Sabatini DM: Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides. Nature. 2014, 508: 108-112. 10.1038/nature13110.
Article
CAS
PubMed
PubMed Central
Google Scholar
Muller J, Lips KS, Metzner L, Neubert RH, Koepsell H, Brandsch M: Drug specificity and intestinal membrane localization of human organic cation transporters (OCT). Biochem Pharmacol. 2005, 70: 1851-1860. 10.1016/j.bcp.2005.09.011.
Article
PubMed
Google Scholar
Foretz M, Hebrard S, Leclerc J, Zarrinpashneh E, Soty M, Mithieux G, Sakamoto K, Andreelli F, Viollet B: Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state. J Clin Invest. 2010, 120: 2355-2369. 10.1172/JCI40671.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hundal RS, Krssak M, Dufour S, Laurent D, Lebon V, Chandramouli V, Inzucchi SE, Schumann WC, Petersen KF, Landau BR, Shulman GI: Mechanism by which metformin reduces glucose production in type 2 diabetes. Diabetes. 2000, 49: 2063-2069. 10.2337/diabetes.49.12.2063.
Article
CAS
PubMed
PubMed Central
Google Scholar
Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA, Montminy M, Cantley LC: The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science. 2005, 310: 1642-1646. 10.1126/science.1120781.
Article
CAS
PubMed
PubMed Central
Google Scholar
Pollak MN: Investigating metformin for cancer prevention and treatment: the end of the beginning. Cancer Discovery. 2012, 2: 778-790. 10.1158/2159-8290.CD-12-0263.
Article
CAS
PubMed
Google Scholar
Madiraju AK, Erion DM, Rahimi Y, Zhang XM, Braddock DT, Albright RA, Prigaro BJ, Wood JL, Bhanot S, MacDonald MJ, Jurczak MJ, Camporez JP, Lee HY, Cline GVV, Samuel VT, Kibbey RG, Shulman GI: Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase. Nature. 2014, 510: 542-546. 10.1038/nature13270.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mullen AR, DeBerardinis RJ: Genetically-defined metabolic reprogramming in cancer. Trends Endocrinol Metab. 2012, 23: 552-559. 10.1016/j.tem.2012.06.009.
Article
CAS
PubMed
PubMed Central
Google Scholar
Calabrese C, Iommarini L, Kurelac I, Calvaruso MA, Capristo M, Lollini PL, Nanni P, Bergamini C, Nicoletti G, Giovanni CD, Ghelli A, Giorgio V, Caratozzolo MF, Marzano F, Manzari C, Betts CM, Carelli V, Ceccarelli C, Attimonelli M, Romeo G, Fato R, Rugolo M, Tullo A, Gasparre G, Porcelli AM: Respiratory complex I is essential to induce a Warburg profile in mitochondria-defective tumor cells. Cancer Metab. 2013, 1: 11-10.1186/2049-3002-1-11.
Article
PubMed
PubMed Central
Google Scholar
Bhalla K, Hwang BJ, Dewi RE, Ou L, Twaddel W, Fang HB, Vafai SB, Vazquez F, Puigserver P, Boros L, Girnun GD: PGC1alpha promotes tumor growth by inducing gene expression programs supporting lipogenesis. Cancer Res. 2011, 71: 6888-6898. 10.1158/0008-5472.CAN-11-1011.
Article
CAS
PubMed
PubMed Central
Google Scholar
Deblois G, Chahrour G, Perry MC, Sylvain-Drolet G, Muller WJ, Giguere V: Transcriptional control of the ERBB2 amplicon by ERRalpha and PGC-1beta promotes mammary gland tumorigenesis. Cancer Res. 2010, 70: 10277-10287. 10.1158/0008-5472.CAN-10-2840.
Article
CAS
PubMed
Google Scholar
Klimcakova E, Chenard V, McGuirk S, Germain D, Avizonis D, Muller WJ, St-Pierre J: PGC-1alpha promotes the growth of ErbB2/Neu-induced mammary tumors by regulating nutrient supply. Cancer Res. 2012, 72: 1538-1546. 10.1158/0008-5472.CAN-11-2967.
Article
CAS
PubMed
Google Scholar
Tennakoon JB, Shi Y, Han JJ, Tsouko E, White MA, Burns AR, Zhang A, Xia X, Ilkayeva OR, Xin L, Ittmann MM, Rick FG, Schally AV, Frigo DE: Androgens regulate prostate cancer cell growth via an AMPK-PGC-1alpha-mediated metabolic switch. Oncogene. 2013, doi:10.1038/onc.2013.463
Google Scholar
Vazquez F, Lim JH, Chim H, Bhalla K, Girnun G, Pierce K, Clish CB, Granter SR, Widlund HR, Spiegelman BM, Puigserver P: PGC1alpha expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress. Cancer Cell. 2013, 23: 287-301. 10.1016/j.ccr.2012.11.020.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ursini-Siegel J, Rajput AB, Lu H, Sanguin-Gendreau V, Zuo D, Papavasiliou V, Lavoie C, Turpin J, Cianflone K, Huntsman DG, Muller WJ: Elevated expression of DecR1 impairs ErbB2/Neu-induced mammary tumor development. Mol Cell Biol. 2007, 27: 6361-6371. 10.1128/MCB.00686-07.
Article
CAS
PubMed
PubMed Central
Google Scholar
Fantin VR, St-Pierre J, Leder P: Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell. 2006, 9: 425-434. 10.1016/j.ccr.2006.04.023.
Article
CAS
PubMed
Google Scholar
Austin S, Klimcakova E, St-Pierre J: Impact of PGC-1alpha on the topology and rate of superoxide production by the mitochondrial electron transport chain. Free Radic Biol Med. 2011, 51: 2243-2248. 10.1016/j.freeradbiomed.2011.08.036.
Article
CAS
PubMed
Google Scholar
Mamer O, Gravel SP, Choiniere L, Chenard V, St-Pierre J, Avizonis D: The complete targeted profile of the organic acid intermediates of the citric acid cycle using a single stable isotope dilution analysis, sodium borodeuteride reduction and selected ion monitoring GC/MS. Metabolomics. 2013, 9: 1019-1030. 10.1007/s11306-013-0521-1.
Article
CAS
PubMed
PubMed Central
Google Scholar
Gravel SP, Andrzejewski S, Avizonis D, St-Pierre J: Stable isotope tracer analysis in isolated mitochondria from mammalian systems. Metabolites. 2014, 4: 166-183. 10.3390/metabo4020166.
Article
PubMed
PubMed Central
Google Scholar
Morita M, Gravel SP, Chenard V, Sikstrorn K, Zheng L, Alain T, Gandin V, Avizonis D, Arguello M, Zakaria C, McLaughlan S, Nouet Y, Pause A, Pollak M, Gottlieb E, Larsson O, St-Pierre J, Topisirovic I, Sonenberg N: mTORC1 controls mitochondrial activity and biogenesis through 4E-BP- dependent translational regulation. Cell Metab. 2013, 18: 698-711. 10.1016/j.cmet.2013.10.001.
Article
CAS
PubMed
Google Scholar
Rossignol R, Gilkerson R, Aggeler R, Yamagata K, Remington SJ, Capaldi RA: Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells. Cancer Res. 2004, 64: 985-993. 10.1158/0008-5472.CAN-03-1101.
Article
CAS
PubMed
Google Scholar
Fendt SM, Bell EL, Keibler MA, Olenchock BA, Mayers JR, Wasylenko TM, Vokes NI, Guarente L, Vander Heiden MG, Stephanopoulos G: Reductive glutamine metabolism is a function of the alpha-ketoglutarate to citrate ratio in cells. Nat Commun. 2013, 4: 2236-
Article
PubMed
PubMed Central
Google Scholar
Mullen AR, Wheaton WW, Jin ES, Chen PH, Sullivan LB, Cheng T, Yang Y, Linehan WM, Chandel NS, DeBerardinis RJ: Reductive carboxylation supports growth in tumour cells with defective mitochondria. Nature. 2012, 481: 385-388.
CAS
PubMed Central
Google Scholar
Brand MD, Nicholls DG: Assessing mitochondrial dysfunction in cells. Biochem J. 2011, 435: 297-312. 10.1042/BJ20110162.
Article
CAS
PubMed
PubMed Central
Google Scholar
Elustondo PA, White AE, Hughes ME, Brebner K, Pavlov E, Kane DA: Physical and functional association of lactate dehydrogenase (LDH) with skeletal muscle mitochondria. J Biol Chem. 2013, 288: 25309-25317. 10.1074/jbc.M113.476648.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wheaton WW, Weinberg SE, Hamanaka RB, Soberanes S, Sullivan LB, Anso E, Glasauer A, Dufour E, Mutlu GM, Budigner GS, Chandel NS: Metformin inhibits mitochondrial complex I of cancer cells to reduce tumourgeneis. eLife. 2014, 3: e02242-
Article
PubMed
PubMed Central
Google Scholar
Bridges HR, Jones AJ, Pollak MN, Hirst J: Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria. The Biochemical journal. 2014, doi:10.1042/BJ20140620
Google Scholar
Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, Nathan DM, Diabetes Prevention Program Research, G: Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002, 346: 393-403.
Article
CAS
PubMed
Google Scholar
Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, Nathan DM, Diabetes Prevention Program Research, G: Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002, 346: 393-403.
Article
CAS
PubMed
Google Scholar
Grundlingh J, Dargan PI, El-Zanfaly M, Wood DM: 2,4-dinitrophenol (DNP): a weight loss agent with significant acute toxicity and risk of death. J Med Toxicol. 2011, 7: 205-212. 10.1007/s13181-011-0162-6.
Article
CAS
PubMed
PubMed Central
Google Scholar
Perry RJ, Kim T, Zhang XM, Lee HY, Pesta D, Popov VB, Zhang D, Rahimi Y, Jurczak MJ, Cline GW, Spiegel DA, Shulman GI: Reversal of hypertriglyceridemia, fatty liver disease, and insulin resistance by a liver-targeted mitochondrial uncoupler. Cell Metab. 2013, 18: 740-748. 10.1016/j.cmet.2013.10.004.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yang C, Sudderth J, Dang T, Bachoo RM, McDonald JG, DeBerardinis RJ: Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling. Cancer Res. 2009, 69: 7986-7993. 10.1158/0008-5472.CAN-09-2266.
Article
CAS
PubMed
PubMed Central
Google Scholar
Javeshghani S, Zakikhani M, Austin S, Bazile M, Blouin MJ, Topisirovic I, St-Pierre J, Pollak MN: Carbon source and myc expression influence the antiproliferative actions of metformin. Cancer Res. 2012, 72: 6257-6267. 10.1158/0008-5472.CAN-12-2907.
Article
CAS
PubMed
Google Scholar
Haq R, Shoag J, Andreu-Perez P, Yokoyama S, Edelman H, Rowe GC, Frederick DT, Hurley AD, Nellore A, Kung AL, Wargo JA, Song JS, Fisher DE, Arany Z, Widlund HR: Oncogenic BRAF regulates oxidative metabolism via PGC1alpha and MITF. Cancer Cell. 2013, 23: 302-315. 10.1016/j.ccr.2013.02.003.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chen LB: Mitochondrial membrane potential in living cells. Annu Rev Cell Biol. 1988, 4: 155-181. 10.1146/annurev.cb.04.110188.001103.
Article
CAS
PubMed
Google Scholar
Fantin VR, Leder P: Mitochondriotoxic compounds for cancer therapy. Oncogene. 2006, 25: 4787-4797. 10.1038/sj.onc.1209599.
Article
CAS
PubMed
Google Scholar