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  1. Calorie restriction (CR) is one of the most potent broadly acting dietary interventions for inducing weight loss and for inhibiting cancer in experimental models. Translation of the mechanistic lessons learned...

    Authors: Stephen D Hursting, Sarah M Dunlap, Nikki A Ford, Marcie J Hursting and Laura M Lashinger
    Citation: Cancer & Metabolism 2013 1:10
  2. The p53 tumor suppressor protein is a transcription factor that initiates transcriptional programs aimed at inhibiting carcinogenesis. p53 represses metabolic pathways that support tumor development (such as g...

    Authors: Ido Goldstein, Keren Yizhak, Shalom Madar, Naomi Goldfinger, Eytan Ruppin and Varda Rotter
    Citation: Cancer & Metabolism 2013 1:9
  3. Cancer cells engage in aerobic glycolysis and glutaminolysis to fulfill their biosynthetic and energetic demands in part by activating MYC. Previous reports have characterized metabolic changes in proliferating c...

    Authors: Elena Anso, Andrew R Mullen, Dean W Felsher, José M Matés, Ralph J DeBerardinis and Navdeep S Chandel
    Citation: Cancer & Metabolism 2013 1:7
  4. Metabolic reprogramming is a key event in tumorigenesis to support cell growth, and cancer cells frequently become both highly glycolytic and glutamine dependent. Similarly, T lymphocytes (T cells) modify thei...

    Authors: Andrew N Macintyre and Jeffrey C Rathmell
    Citation: Cancer & Metabolism 2013 1:5
  5. Tissue imaging of treatment-induced metabolic changes is useful for optimizing cancer therapies, but commonly used methods require trade-offs between assay sensitivity and spatial resolution. Nanostructure-Ini...

    Authors: Peter J O’Brien, Michelle Lee, Mary E Spilker, Cathy C Zhang, Zhengming Yan, Timothy C Nichols, Wenlin Li, Caroline H Johnson, Gary J Patti and Gary Siuzdak
    Citation: Cancer & Metabolism 2013 1:4
  6. Regulation of lipid metabolism via activation of sterol regulatory element binding proteins (SREBPs) has emerged as an important function of the Akt/mTORC1 signaling axis. Although the contribution of dysregul...

    Authors: Beatrice Griffiths, Caroline A Lewis, Karim Bensaad, Susana Ros, Qifeng Zhang, Emma C Ferber, Sofia Konisti, Barrie Peck, Heike Miess, Philip East, Michael Wakelam, Adrian L Harris and Almut Schulze
    Citation: Cancer & Metabolism 2013 1:3
  7. While aerobic glycolysis is linked to unconstrained proliferation in cancer, less is known about its physiological role. Why this metabolic program that promotes tumor growth is preserved in the genome has thu...

    Authors: Timothy R Gershon, Andrew J Crowther, Andrey Tikunov, Idoia Garcia, Ryan Annis, Hong Yuan, C Ryan Miller, Jeffrey Macdonald, James Olson and Mohanish Deshmukh
    Citation: Cancer & Metabolism 2013 1:2

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