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  1. Overweight or obesity has been evidenced as an important risk factor involved in the incidence, mortality, and therapy response of multiple malignancies. However, the differences between healthy and obesity tu...

    Authors: Chao Hu, Xiong Chen, Chengyun Yao, Yu Liu, Haojun Xu, Guoren Zhou, Hongping Xia and Jinglin Xia

    Citation: Cancer & Metabolism 2020 8:21

    Content type: Research

    Published on:

  2. Mitochondrial serine catabolism to formate induces a metabolic switch to a hypermetabolic state with high rates of glycolysis, purine synthesis and pyrimidine synthesis. While formate is a purine precursor, it...

    Authors: Jacqueline Tait-Mulder, Kelly Hodge, David Sumpton, Sara Zanivan and Alexei Vazquez

    Citation: Cancer & Metabolism 2020 8:20

    Content type: Research

    Published on:

  3. Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant forms of cancer. Lack of effective treatment options and drug resistance contributes to the low survival among PDAC patients. In this study,...

    Authors: Neha Sharma, Alok Bhushan, Jun He, Gagan Kaushal and Vikas Bhardwaj

    Citation: Cancer & Metabolism 2020 8:19

    Content type: Short Report

    Published on:

  4. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Masahiro Kawashima, Karim Bensaad, Christos E. Zois, Alessandro Barberis, Esther Bridges, Simon Wigfield, Christoffer Lagerholm, Ruslan I. Dmitriev, Mariko Tokiwa, Masakazu Toi, Dmitri B. Papkovsky, Francesca M. Buffa and Adrian L. Harris

    Citation: Cancer & Metabolism 2020 8:18

    Content type: Correction

    Published on:

    The original article was published in Cancer & Metabolism 2020 8:13

  5. Glioblastoma (GBM) are highly heterogeneous on the cellular and molecular basis. It has been proposed that glutamine metabolism of primary cells established from human tumors discriminates aggressive mesenchym...

    Authors: Kristell Oizel, Chendong Yang, Ophelie Renoult, Fabien Gautier, Quyen N. Do, Noemie Joalland, Xiaofei Gao, Bookyung Ko, François Vallette, Woo-Ping Ge, François Paris, Ralph J. DeBerardinis and Claire Pecqueur

    Citation: Cancer & Metabolism 2020 8:9

    Content type: Research

    Published on:

  6. The loss-of-function mutation of fumarate hydratase (FH) is a driver of hereditary leiomyomatosis and renal cell carcinoma (HLRCC). Fumarate accumulation results in activation of stress-related mechanisms lead...

    Authors: Rony Panarsky, Daniel R. Crooks, Andrew N. Lane, Youfeng Yang, Teresa A. Cassel, Teresa W.-M. Fan, W. Marston Linehan and Jeffrey A. Moscow

    Citation: Cancer & Metabolism 2020 8:7

    Content type: Research

    Published on:

  7. During breast cancer progression, the epithelial to mesenchymal transition has been associated with metastasis and endocrine therapy resistance; however, the underlying mechanisms remain elusive. To gain insig...

    Authors: Tamara Fernández-Calero, Marcos Davyt, Karen Perelmuter, Cora Chalar, Giovana Bampi, Helena Persson, Juan Pablo Tosar, Völundur Hafstað, Hugo Naya, Carlos Rovira, Mariela Bollati-Fogolín, Ricardo Ehrlich, Gilles Flouriot, Zoya Ignatova and Mónica Marín

    Citation: Cancer & Metabolism 2020 8:8

    Content type: Research

    Published on:

  8. ErbB2 breast cancer still remains an unmet need due to primary and/or acquired resistance to current treatment strategies. MEDICA compounds consist of synthetic long-chain α,ω-dicarboxylic acids previously rep...

    Authors: Sophia Eldad, Rachel Hertz, Gilad Vainer, Ann Saada and Jacob Bar-Tana

    Citation: Cancer & Metabolism 2020 8:17

    Content type: Research

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  9. Obesity and metabolic syndrome are strongly associated with cancer, and these disorders may share a common mechanism. Recently, fructose has emerged as a driving force to develop obesity and metabolic syndrome...

    Authors: Takahiko Nakagawa, Miguel A. Lanaspa, Inigo San Millan, Mehdi Fini, Christopher J. Rivard, Laura G. Sanchez-Lozada, Ana Andres-Hernando, Dean R. Tolan and Richard J. Johnson

    Citation: Cancer & Metabolism 2020 8:16

    Content type: Review

    Published on:

  10. Humans produce heat through non-shivering thermogenesis, a metabolic process that occurs in inducible beige adipocytes expressing uncoupling protein 1 (UCP1). UCP1 dissipates the proton gradient of the mitocho...

    Authors: Masahiro Kawashima, Karim Bensaad, Christos E. Zois, Alessandro Barberis, Esther Bridges, Simon Wigfield, Christoffer Lagerholm, Ruslan I. Dmitriev, Mariko Tokiwa, Masakazu Toi, Dmitri B. Papkovsky, Francesca M. Buffa and Adrian L. Harris

    Citation: Cancer & Metabolism 2020 8:13

    Content type: Research

    Published on:

    The Correction to this article has been published in Cancer & Metabolism 2020 8:18

  11. The treatment of diffuse large B-cell lymphoma (DLBCL) is limited by the development of resistance to therapy, and there is a need to develop novel therapeutic strategies for relapsed and refractory aggressive...

    Authors: Anil R. Singh, Juan J. Gu, Qunling Zhang, Pallawi Torka, Suchitra Sundaram, Cory Mavis and Francisco J. Hernandez-Ilizaliturri

    Citation: Cancer & Metabolism 2020 8:10

    Content type: Research

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  12. In 2006, a new model of invasive breast tumor emerged and, since 2011, is gaining recognition and research momentum. “Tumor-associated collagen signatures” describe 3 distinct layers of collagen which radiate ...

    Authors: Elizabeth A. Brett, Matthias A. Sauter, Hans-Günther Machens and Dominik Duscher

    Citation: Cancer & Metabolism 2020 8:14

    Content type: Review

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  13. Metabolic reprograming, non-mutational epigenetic changes, increased cell plasticity, and multidrug tolerance are early hallmarks of therapy resistance in cancer. In this temporary, therapy-tolerant state, can...

    Authors: Kaylyn D. Tousignant, Anja Rockstroh, Berwyck L. J. Poad, Ali Talebi, Reuben S. E. Young, Atefeh Taherian Fard, Rajesh Gupta, Tuo Zang, Chenwei Wang, Melanie L. Lehman, Johan V. Swinnen, Stephen J. Blanksby, Colleen C. Nelson and Martin C. Sadowski

    Citation: Cancer & Metabolism 2020 8:11

    Content type: Research

    Published on:

  14. d-3-phosphoglycerate dehydrogenase (PHGDH), which encodes the first enzyme in serine biosynthesis, is overexpressed in human cancers and has been proposed as a drug target. However, whether PHGDH is critical fo.....

    Authors: Yun Pyo Kang, Aimee Falzone, Min Liu, Paloma González-Sánchez, Bo-Hyun Choi, Jonathan L. Coloff, James J. Saller, Florian A. Karreth and Gina M. DeNicola

    Citation: Cancer & Metabolism 2020 8:6

    Content type: Research

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  15. Tumor initiation and progression are associated with numerous metabolic alterations. However, the biochemical drivers and constraints that contribute to metabolic gene dysregulation are unclear.

    Authors: Krishnadev Oruganty, Scott Edward Campit, Sainath Mamde, Costas A. Lyssiotis and Sriram Chandrasekaran

    Citation: Cancer & Metabolism 2020 8:5

    Content type: Methodology

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  16. High glycolytic rate is a hallmark of cancer (Warburg effect). Glycolytic ATP is required for fuelling plasma membrane calcium ATPases (PMCAs), responsible for extrusion of cytosolic calcium, in pancreatic duc...

    Authors: D. A. Richardson, P. Sritangos, A. D. James, A. Sultan and J. I. E. Bruce

    Citation: Cancer & Metabolism 2020 8:2

    Content type: Research

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  17. Osteosarcoma (OS) is a malignant bone tumor that often develops during the period of rapid growth associated with adolescence. Despite successful primary tumor control accompanied by adjuvant chemotherapy, dea...

    Authors: L. Ren, V. Ruiz-Rodado, T. Dowdy, S. Huang, S. H. Issaq, J. Beck, H. Wang, C. Tran Hoang, A. Lita, M. Larion and A. K. LeBlanc

    Citation: Cancer & Metabolism 2020 8:4

    Content type: Research

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  18. Colorectal cancer (CRC) is a complex multifactorial disease. Increasing evidence suggests that the microbiome is involved in different stages of CRC initiation and progression. Beyond specific pro-oncogenic me...

    Authors: Daniel R. Garza, Rahwa Taddese, Jakob Wirbel, Georg Zeller, Annemarie Boleij, Martijn A. Huynen and Bas E. Dutilh

    Citation: Cancer & Metabolism 2020 8:3

    Content type: Research

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  19. Metabolic programs in cancer cells are influenced by genotype and the tissue of origin. We have previously shown that central carbon metabolism is rewired in pancreatic ductal adenocarcinoma (PDA) to support p...

    Authors: Barbara S. Nelson, Lin Lin, Daniel M. Kremer, Cristovão M. Sousa, Cecilia Cotta-Ramusino, Amy Myers, Johanna Ramos, Tina Gao, Ilya Kovalenko, Kari Wilder-Romans, Joseph Dresser, Mary Davis, Ho-Joon Lee, Zeribe C. Nwosu, Scott Campit, Oksana Mashadova…

    Citation: Cancer & Metabolism 2020 8:1

    Content type: Research

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  20. Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with limited treatment options. Pyruvate kinase, especially the M2 isoform (PKM2), is highly expressed in PDAC cells, but its role in pancreatic ...

    Authors: Lei Yu, Shao Thing Teoh, Elliot Ensink, Martin P. Ogrodzinski, Che Yang, Ana I. Vazquez and Sophia Y. Lunt

    Citation: Cancer & Metabolism 2019 7:13

    Content type: Research

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  21. Hypoxia-inducible factors (HIF)1 and 2 are transcription factors that regulate the homeostatic response to low oxygen conditions. Since data related to the importance of HIF1 and 2 in hematopoietic stem and pr...

    Authors: Albertus T. J. Wierenga, Alan Cunningham, Ayşegül Erdem, Nuria Vilaplana Lopera, Annet Z. Brouwers-Vos, Maurien Pruis, André B. Mulder, Ulrich L. Günther, Joost H. A. Martens, Edo Vellenga and Jan Jacob Schuringa

    Citation: Cancer & Metabolism 2019 7:11

    Content type: Research

    Published on:

  22. Obesity confers an increased risk and accelerates the progression of multiple tumor types in rodents and humans, including both breast and colon cancer. Because sustained weight loss is rarely achieved, therap...

    Authors: Ali R. Nasiri, Marcos R. Rodrigues, Zongyu Li, Brooks P. Leitner and Rachel J. Perry

    Citation: Cancer & Metabolism 2019 7:10

    Content type: Research

    Published on:

  23. Metabolic reprogramming is a key feature of malignant cells. While glucose is one of the primary substrates for malignant cells, cancer cells also display a remarkable metabolic flexibility. Depending on nutri...

    Authors: Emily D. Montal, Kavita Bhalla, Ruby E. Dewi, Christian F. Ruiz, John A. Haley, Ashley E. Ropell, Chris Gordon, John D. Haley and Geoffrey D. Girnun

    Citation: Cancer & Metabolism 2019 7:8

    Content type: Research

    Published on:

  24. Mitochondrial oxidative phosphorylation (OXPHOS) via the respiratory chain is required for the maintenance of tumour cell proliferation and regulation of epithelial to mesenchymal transition (EMT)-related phen...

    Authors: Luke W. Thomas, Cinzia Esposito, Jenna M. Stephen, Ana S. H. Costa, Christian Frezza, Thomas S. Blacker, Gyorgy Szabadkai and Margaret Ashcroft

    Citation: Cancer & Metabolism 2019 7:7

    Content type: Research

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  25. Epithelial to mesenchymal transition (EMT) is a well-characterized process of cell plasticity that may involve metabolic rewiring. In cancer, EMT is associated with malignant progression, tumor heterogeneity, ...

    Authors: Gro V. Røsland, Sissel E. Dyrstad, Deusdedit Tusubira, Reham Helwa, Tuan Zea Tan, Maria L. Lotsberg, Ina K. N. Pettersen, Anna Berg, Charlotte Kindt, Fredrik Hoel, Kirstine Jacobsen, Ari J. Arason, Agnete S. T. Engelsen, Henrik J. Ditzel, Per E. Lønning, Camilla Krakstad…

    Citation: Cancer & Metabolism 2019 7:6

    Content type: Research

    Published on:

  26. Mutations in isocitrate dehydrogenase 1 (IDH1) occur in various types of cancer and induce metabolic alterations resulting from the neomorphic activity that causes production of D-2-hydroxyglutarate (D-2-HG) at t...

    Authors: Tom H. Peeters, Krissie Lenting, Vincent Breukels, Sanne A. M. van Lith, Corina N. A. M. van den Heuvel, Remco Molenaar, Arno van Rooij, Ron Wevers, Paul N. Span, Arend Heerschap and William P. J. Leenders

    Citation: Cancer & Metabolism 2019 7:4

    Content type: Research

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  27. Breast cancer (BC) is the most common female cancer and the leading cause of cancer death in women worldwide. Alterations in epithelial cadherin (E-cadherin) expression and functions are associated to BC, but ...

    Authors: Marina Rosso, Lara Lapyckyj, María José Besso, Marta Monge, Jaume Reventós, Francesc Canals, Jorge Oswaldo Quevedo Cuenca, María Laura Matos and Mónica Hebe Vazquez-Levin

    Citation: Cancer & Metabolism 2019 7:5

    Content type: Research

    Published on:

  28. Serum and urine metabolites have been investigated for their use as cancer biomarkers. The specificity of candidate metabolites can be limited by the impact of other disorders on metabolite levels. In particul...

    Authors: Matthias Pietzke, Salvador Fernandez Arroyo, David Sumpton, Gillian M. Mackay, Begoña Martin-Castillo, Jordi Camps, Jorge Joven, Javier A. Menendez and Alexei Vazquez

    Citation: Cancer & Metabolism 2019 7:3

    Content type: Research

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  29. Tumour cells rely on glycolysis and mitochondrial oxidative phosphorylation (OXPHOS) to survive. Thus, mitochondrial OXPHOS has become an increasingly attractive area for therapeutic exploitation in cancer. Ho...

    Authors: Luke W. Thomas, Jenna M. Stephen, Cinzia Esposito, Simon Hoer, Robin Antrobus, Afshan Ahmed, Hasan Al-Habib and Margaret Ashcroft

    Citation: Cancer & Metabolism 2019 7:2

    Content type: Research

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  30. The role of tumor protein D54 in breast cancer has not been studied and its function in breast cancer remains unclear. In our previous pharmacogenomic studies using lymphoblastoid cell line (LCL), this protein...

    Authors: Yongxian Zhuang, Reynold C. Ly, Carleigh V. Frazier, Jia Yu, Sisi Qin, Xiao-Yang Fan, Matthew P. Goetz, Judy C. Boughey, Richard Weinshilboum and Liewei Wang

    Citation: Cancer & Metabolism 2019 7:1

    Content type: Research

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  31. Recent in vitro and in vivo work has shown that lactate provides an important source of carbon for metabolic reactions in cancer cell mitochondria. An interesting question is whether lactate is oxidized by lactat...

    Authors: Xiangfeng Niu, Ying-Jr Chen, Peter A. Crawford and Gary J. Patti

    Citation: Cancer & Metabolism 2018 6:19

    Content type: Rapid communication

    Published on:

  32. In response to oncogenic stress, the tumour suppressor protein p53 can induce the elimination of cells through induction of cell death or senescence, helping to restrain malignant progression. Conversely, unde...

    Authors: Timothy J. Humpton, Andreas K. Hock, Oliver D. K. Maddocks and Karen H. Vousden

    Citation: Cancer & Metabolism 2018 6:18

    Content type: Rapid communication

    Published on:

  33. While self-reported exercise is associated with a reduction in the risk of recurrence in colorectal cancer, the molecular mechanisms underpinning this relationship are unknown. Furthermore, the effect of exerc...

    Authors: Min Lu, Sydney M Sanderson, Amelia Zessin, Kathleen A Ashcraft, Lee W Jones, Mark W Dewhirst, Jason W Locasale and David S Hsu

    Citation: Cancer & Metabolism 2018 6:14

    Content type: Research

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  34. It is becoming increasingly recognized that weight and nutritional status can impact cancer survival. We have previously shown that obese mice with syngeneic acute lymphoblastic leukemia (ALL) have poorer resp...

    Authors: Jonathan Tucci, Waseem Alhushki, Ting Chen, Xia Sheng, Yong-Mi Kim and Steven D. Mittelman

    Citation: Cancer & Metabolism 2018 6:15

    Content type: Rapid communication

    Published on:

  35. PCSK9 regulates low-density lipoprotein cholesterol (LDLc) level and has been implicated in hypercholesterolemia. Aberrant plasma lipid profile is often associated with various cancers. Clinically, the relatio...

    Authors: Dipti Athavale, Surbhi Chouhan, Vimal Pandey, Shyamananda Singh Mayengbam, Snahlata Singh and Manoj Kumar Bhat

    Citation: Cancer & Metabolism 2018 6:16

    Content type: Research

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  36. While most cancer cells preferentially express the M2 isoform of the glycolytic enzyme pyruvate kinase (PKM2), PKM2 is dispensable for tumor development in several mouse cancer models. PKM2 is expressed in hum...

    Authors: Alissandra L Hillis, Allison N Lau, Camille X Devoe, Talya L Dayton, Laura V Danai, Dolores Di Vizio and Matthew G Vander Heiden

    Citation: Cancer & Metabolism 2018 6:17

    Content type: Short Report

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  37. Cancer cell metabolism requires sustained pools of intracellular nicotinamide adenine dinucleotide (NAD+) which is maintained by a balance of NAD+ hydrolase activity and NAD+ salvage activity. We recently reporte...

    Authors: Jack Mottahedeh, Michael C. Haffner, Tristan R. Grogan, Takao Hashimoto, Preston D. Crowell, Himisha Beltran, Andrea Sboner, Rohan Bareja, David Esopi, William B. Isaacs, Srinivasan Yegnasubramanian, Matthew B. Rettig, David A. Elashoff, Elizabeth A. Platz, Angelo M. De Marzo, Michael A. Teitell…

    Citation: Cancer & Metabolism 2018 6:13

    Content type: Research

    Published on:

  38. We have previously identified 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], the bioactive form of vitamin D3, as a potent regulator of energy-utilization and nutrient-sensing pathways in prostate cancer cells. In the c...

    Authors: Mohamed A. Abu el Maaty, Yasamin Dabiri, Fadi Almouhanna, Biljana Blagojevic, Jannick Theobald, Michael Büttner and Stefan Wölfl

    Citation: Cancer & Metabolism 2018 6:11

    Content type: Research

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  39. T cells and cancer cells utilize glycolysis for proliferation. The hexokinase (1–4) family of enzymes catalyze the first step of glycolysis. Hexokinase 2 (HK2) is one of the most highly upregulated metabolic e...

    Authors: Manan M. Mehta, Samuel E. Weinberg, Elizabeth M. Steinert, Krishan Chhiba, Carlos Alberto Martinez, Peng Gao, Harris R. Perlman, Paul Bryce, Nissim Hay and Navdeep S. Chandel

    Citation: Cancer & Metabolism 2018 6:10

    Content type: Research

    Published on:

  40. Inflammation, metabolism, and epigenetic modulation are highly interconnected processes that can be altered during tumorigenesis. However, because of the complexity of these interactions, direct cause and effe...

    Authors: Ashley R. Maiuri, Hongde Li, Barry D. Stein, Jason M. Tennessen and Heather M. O’Hagan

    Citation: Cancer & Metabolism 2018 6:9

    Content type: Research

    Published on:

  41. Precision medicine therapies require identification of unique molecular cancer characteristics. Hexokinase (HK) activity has been proposed as a therapeutic target; however, different hexokinase isoforms have n...

    Authors: Shili Xu, Arthur Catapang, Daniel Braas, Linsey Stiles, Hanna M. Doh, Jason T. Lee, Thomas G. Graeber, Robert Damoiseaux, Orian Shirihai and Harvey R. Herschman

    Citation: Cancer & Metabolism 2018 6:7

    Content type: Research

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  42. Ketogenic diets (KDs) or short-term fasting are popular trends amongst supportive approaches for cancer patients. Beta-hydroxybutyrate (3-OHB) is the main physiological ketone body, whose concentration can rea...

    Authors: Catharina Bartmann, Sudha R. Janaki Raman, Jessica Flöter, Almut Schulze, Katrin Bahlke, Jana Willingstorfer, Maria Strunz, Achim Wöckel, Rainer J. Klement, Michaela Kapp, Cholpon S. Djuzenova, Christoph Otto and Ulrike Kämmerer

    Citation: Cancer & Metabolism 2018 6:8

    Content type: Research

    Published on:

  43. Alternative splicing of the Pkm gene product generates the PKM1 and PKM2 isoforms of the glycolytic enzyme pyruvate kinase. PKM2 expression is associated with embryogenesis, tissue regeneration, and cancer. PKM2 ...

    Authors: Talya L. Dayton, Vasilena Gocheva, Kathryn M. Miller, Arjun Bhutkar, Caroline A. Lewis, Roderick T. Bronson, Matthew G. Vander Heiden and Tyler Jacks

    Citation: Cancer & Metabolism 2018 6:6

    Content type: Research

    Published on:

  44. There is considerable interest in defining the metabolic abnormalities of IDH mutant tumors to exploit for therapy. While most studies have attempted to discern function by using cell lines transduced with exo...

    Authors: Matthew Garrett, Jantzen Sperry, Daniel Braas, Weihong Yan, Thuc M. Le, Jack Mottahedeh, Kirsten Ludwig, Ascia Eskin, Yue Qin, Rachelle Levy, Joshua J. Breunig, Frank Pajonk, Thomas G. Graeber, Caius G. Radu, Heather Christofk, Robert M. Prins…

    Citation: Cancer & Metabolism 2018 6:4

    Content type: Research

    Published on:

  45. Magnetic resonance spectroscopy (MRS) studies have identified elevated levels of the phospholipid precursor phosphocholine (PC) and phosphoethanolamine (PE) as metabolic hallmarks of cancer. Unusually, however...

    Authors: Pavithra Viswanath, Marina Radoul, Jose Luis Izquierdo-Garcia, Hema Artee Luchman, J. Gregory Cairncross, Russell O. Pieper, Joanna J. Phillips and Sabrina M. Ronen

    Citation: Cancer & Metabolism 2018 6:3

    Content type: Research

    Published on:

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As a result of the significant disruption that is being caused by the COVID-19 pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our usual peer review process. We thank referees for their continued support in these challenging times and ask authors for their patience and understanding.

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Annual Journal Metrics

  • Speed
    65 days to first decision for reviewed manuscripts only
    59 days to first decision for all manuscripts
    135 days from submission to acceptance
    35 days from acceptance to publication

    Citation Impact

    5.033 - 2 Year Impact Factor
    0.583 - Immediacy Index

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