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  1. Hypoxia contributes to cancer progression through various molecular mechanisms and hepatocellular carcinoma (HCC) is one of the most hypoxic malignancies. Hypoxia-inducible gene domain protein-1a (HIGD1A) is t...

    Authors: Haixing Zhang, Xiaoran Li, Ziying Liu, Zimo Lin, Kuiyuan Huang, Yiran Wang, Yu Chen, Leyi Liao, Leyuan Wu, Zhanglian Xie, Jinlin Hou, Xiaoyong Zhang and Hongyan Liu
    Citation: Cancer & Metabolism 2024 12:7
  2. Metastasis is the leading cause of death among prostate cancer (PCa) patients. Obesity is associated with both PCa-specific and all-cause mortality. High-fat diet (HFD) is a risk factor contributing to obesity...

    Authors: Dameng Li, Xueying Zhou, Wenxian Xu, Yongxin Cai, Chenglong Mu, Xinchun Zhao, Tingting Tang, Chen Liang, Tao Yang, Junnian Zheng, Liang Wei and Bo Ma
    Citation: Cancer & Metabolism 2024 12:6
  3. PDE6H encodes PDE6γ′, the inhibitory subunit of the cGMP-specific phosphodiesterase 6 in cone photoreceptors. Inhibition of PDE6, which has been widely studied for its role in light transduction, increases cGMP l...

    Authors: Ceren Yalaz, Esther Bridges, Nasullah K. Alham, Christos E. Zois, Jianzhou Chen, Karim Bensaad, Ana Miar, Elisabete Pires, Ruth J. Muschel, James S. O. McCullagh and Adrian L. Harris
    Citation: Cancer & Metabolism 2024 12:5
  4. Circulating metabolites systemically reflect cellular processes and can modulate the tissue microenvironment in complex ways, potentially impacting cancer initiation processes. Genetic background increases can...

    Authors: Tiina A. Jokela, Jari E. Karppinen, Minta Kärkkäinen, Jukka-Pekka Mecklin, Simon Walker, Toni T. Seppälä and Eija K. Laakkonen
    Citation: Cancer & Metabolism 2024 12:4
  5. The C-reactive protein (CRP)-triglyceride-glucose (TyG) index (CTI), which is a measure representing the level of inflammation and insulin resistance (IR), is related to poor cancer prognosis; however, the CTI...

    Authors: Guo-Tian Ruan, Li Deng, Hai-Lun Xie, Jin-Yu Shi, Xiao-Yue Liu, Xin Zheng, Yue Chen, Shi-Qi Lin, He-Yang Zhang, Chen-An Liu, Yi-Zhong Ge, Meng-Meng Song, Chun-Lei Hu, Xiao-Wei Zhang, Ming Yang, Wen Hu…
    Citation: Cancer & Metabolism 2024 12:3
  6. Abnormal glucose metabolism is one of the determinants of maintaining malignant characteristics of cancer. Targeting cancer metabolism is regarded as a new strategy for cancer treatment. Our previous studies h...

    Authors: Hongqiang Wang, Xutao Sun, Chen Yang, Ziqi Li, Danwen Jin, Wenwen Zhu and Ze Yu
    Citation: Cancer & Metabolism 2024 12:2
  7. Adipose tissue metabolism may be impaired in patients with cancer. In particular, increased lipolysis was described in cancer-promoting adipose tissue atrophy.

    Authors: Federica Tambaro, Giovanni Imbimbo, Elisabetta Ferraro, Martina Andreini, Roberta Belli, Maria Ida Amabile, Cesarina Ramaccini, Giulia Lauteri, Giuseppe Nigri, Maurizio Muscaritoli and Alessio Molfino
    Citation: Cancer & Metabolism 2024 12:1
  8. Hepatocellular carcinoma (HCC) is a principal type of liver cancer with high incidence and mortality rates. Regorafenib is a novel oral multikinase inhibitor for second-line therapy for advanced HCC. However, ...

    Authors: Huihua Yang, Dahong Chen, Yafei Wu, Heming Zhou, Wenjing Diao, Gaolin Liu and Qin Li
    Citation: Cancer & Metabolism 2023 11:27
  9. Chemotherapy resistance is the leading cause for hepatocellular carcinoma (HCC)-induced death. Exploring resistance generation mechanism is an urgent need for HCC therapy. Here, we found STEAP4 was significant...

    Authors: Binhui Xie, Baiyin Zhong, Zhenxian Zhao, Jie Hu, Jianqiong Yang, Yuankang Xie, Jianhong Zhang, Jianting Long, Xuewei Yang and Heping Li
    Citation: Cancer & Metabolism 2023 11:26
  10. A hypoxic environment often persists within solid tumors, including hepatocellular carcinoma (HCC). Hypoxia-inducible factor-1α (HIF-1α) can accelerate cancer malignancy by inducing hypoxia-dependent expressio...

    Authors: Shohei Matsufuji, Yoshihiko Kitajima, Kazuki Higure, Naoya Kimura, Sachiko Maeda, Kohei Yamada, Kotaro Ito, Tomokazu Tanaka, Keita Kai and Hirokazu Noshiro
    Citation: Cancer & Metabolism 2023 11:25
  11. The relationship between obesity and non-Hodgkin’s lymphoma (NHL) was controversial, which may be due to the crudeness definition of obesity based on body mass index (BMI). As obesity and metabolic abnormaliti...

    Authors: Hang Dong, Honglin Guo, Jing Du, Yiping Cheng, Dawei Wang, Junming Han, Zinuo Yuan, Zhenyu Yao, Ran An, Xiaoqin Wu, Kyle L. Poulsen, Zhixiang Wang, Shanshan Shao, Xiude Fan, Zhen Wang and Jiajun Zhao
    Citation: Cancer & Metabolism 2023 11:24
  12. Bladder cancer (BLCA) research in Koreans is still lacking, especially in focusing on the prediction of BLCA. The current study aimed to discover metabolic signatures related to BLCA onset and confirm its pote...

    Authors: Youngmin Han, Unchong Kim, Keum Ji Jung, Ji-Young Lee, Kwangbae Lee, Sang Yop Shin, Heejin Kimm and Sun Ha Jee
    Citation: Cancer & Metabolism 2023 11:23
  13. Macrophages are one of the most prevalent subsets of immune cells within the tumor microenvironment and perform a range of functions depending on the cytokines and chemokines released by surrounding cells and ...

    Authors: Shelby N. Bess, Matthew J. Igoe, Abby C. Denison and Timothy J. Muldoon
    Citation: Cancer & Metabolism 2023 11:22
  14. Breast cancer (BC) is the most prevalent tumor in women. Improvements in treatment led to declined mortality, resulting in more survivors living with cancer- or therapy-induced comorbidities. In this study, we...

    Authors: Timia Van Soom, Wiebren Tjalma, Konstantinos Papadimitriou, Nick Gebruers and Eric van Breda
    Citation: Cancer & Metabolism 2023 11:21
  15. ATM is a multifunctional serine/threonine kinase that in addition to its well-established role in DNA repair mechanisms is involved in a number of signaling pathways including regulation of oxidative stress re...

    Authors: Cristina Terlizzi, Viviana De Rosa, Francesca Iommelli, Antonio Pezone, Giovanna G. Altobelli, Maurizio Maddalena, Jelena Dimitrov, Caterina De Rosa, Carminia Maria Della Corte, Vittorio Enrico Avvedimento and Silvana Del Vecchio
    Citation: Cancer & Metabolism 2023 11:20
  16. To support proliferation and survival within a challenging microenvironment, cancer cells must reprogramme their metabolism. As such, targeting cancer cell metabolism is a promising therapeutic avenue. However...

    Authors: Amy K. Holt, Arafath K. Najumudeen, Tracey J. Collard, Hao Li, Laura M. Millett, Ashley J. Hoskin, Danny N. Legge, Eleanor M. H. Mortensson, Dustin J. Flanagan, Nicholas Jones, Madhu Kollareddy, Penny Timms, Matthew D. Hitchings, James Cronin, Owen J. Sansom, Ann C. Williams…
    Citation: Cancer & Metabolism 2023 11:18
  17. Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, but if discovered at an early stage, the survival rate is high. The aim of this study was to identify novel markers predictive of f...

    Authors: Linda Vidman, Rui Zheng, Stina Bodén, Anton Ribbenstedt, Marc J. Gunter, Richard Palmqvist, Sophia Harlid, Carl Brunius and Bethany Van Guelpen
    Citation: Cancer & Metabolism 2023 11:17
  18. Endometrial cancer (EMC) is the most common female genital tract malignancy with an increasing prevalence in many countries including Japan, a fact that renders early detection and treatment necessary to prote...

    Authors: Eiji Hishinuma, Muneaki Shimada, Naomi Matsukawa, Yoshiko Shima, Bin Li, Ikuko N. Motoike, Yusuke Shibuya, Tatsuya Hagihara, Shogo Shigeta, Hideki Tokunaga, Daisuke Saigusa, Kengo Kinoshita, Seizo Koshiba and Nobuo Yaegashi
    Citation: Cancer & Metabolism 2023 11:16
  19. Hypercholesterolemia is often correlated with obesity which is considered a risk factor for various cancers. With the growing population of hypercholesterolemic individuals, there is a need to understand the r...

    Authors: Shyamananda Singh Mayengbam, Abhijeet Singh, Himanshi Yaduvanshi, Firoz Khan Bhati, Bhavana Deshmukh, Dipti Athavale, Pranay L. Ramteke and Manoj Kumar Bhat
    Citation: Cancer & Metabolism 2023 11:15

    The Correction to this article has been published in Cancer & Metabolism 2023 11:19

  20. Tissue environment is critical in determining tumour metabolic vulnerability. However, in vivo drug testing is slow and waiting for tumour growth delay may not be the most appropriate endpoint for metabolic tr...

    Authors: Piotr Dzien, Agata Mackintosh, Gaurav Malviya, Emma Johnson, Dmitry Soloviev, Gavin Brown, Alejandro Huerta Uribe, Colin Nixon, Scott K. Lyons, Oliver Maddocks, Karen Blyth and David Y. Lewis
    Citation: Cancer & Metabolism 2023 11:14
  21. Kaposi sarcoma (KS) is a neoplastic disease etiologically associated with infection by the Kaposi sarcoma-associated herpesvirus (KSHV). KS manifests primarily as cutaneous lesions in individuals due to either...

    Authors: Sara R. Privatt, Camila Pereira Braga, Alicia Johnson, Salum J. Lidenge, Luke Berry, John R. Ngowi, Owen Ngalamika, Andrew G. Chapple, Julius Mwaiselage, Charles Wood, John T. West and Jiri Adamec
    Citation: Cancer & Metabolism 2023 11:13
  22. Kidney renal clear cell carcinoma (KIRC) is the major histological subtype of kidney tumor which covers approximately 80% of the cases. Although various therapies have been developed, the clinical outcome rema...

    Authors: Wenyuan Zhuang, Xiaokai Shi, Shenglin Gao and Xihu Qin
    Citation: Cancer & Metabolism 2023 11:11
  23. Melanoma is considered as the most common metastatic skin cancer with increasing incidence and high mortality globally. The vital roles of long non-coding RNAs (lncRNAs) in the tumorigenesis of melanoma are el...

    Authors: Zhi Ding, Junyi Yang, Baojin Wu, Yingzhi Wu and Fanli Guo
    Citation: Cancer & Metabolism 2023 11:10
  24. Excessive hepatic glycogen accumulation benefits tumorigenesis and cancer cell survival. We previously reported that BMP4 has the strongest ability to promote glycogenesis among the 14 BMPs in hepatocytes and ...

    Authors: Jiamin Zhong, Luyao Tian, Yannian Gou, Piao Zhao, Xiangyu Dong, Meichun Guo, Guozhi Zhao, Aohua Li, Ailing Hao, Tong-Chuan He and Jiaming Fan
    Citation: Cancer & Metabolism 2023 11:9
  25. Examine the association between obesity and clinical outcomes in early breast cancer and assess if patient, tumor, and treatment characteristics modify such associations in Malmö Diet and Cancer Study patients...

    Authors: Sixten Harborg, Maria Feldt, Deirdre Cronin-Fenton, Marie Klintman, Susanne O. Dalton, Ann H. Rosendahl and Signe Borgquist
    Citation: Cancer & Metabolism 2023 11:8
  26. The impact of non-small cell lung cancer (NSCLC) metabolism on the immune microenvironment is not well understood within platinum resistance. We have identified crucial metabolic differences between cisplatin-...

    Authors: Chunjing Wu, Sydney A. Spector, George Theodoropoulos, Dan J. M. Nguyen, Emily Y. Kim, Ashley Garcia, Niramol Savaraj, Diane C. Lim, Ankita Paul, Lynn G. Feun, Michael Bickerdike and Medhi Wangpaichitr
    Citation: Cancer & Metabolism 2023 11:7
  27. Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy. Thus, there is an urgent need for safe and effective novel therapies. PDAC’s excessive reliance on glucose metabolism for its metabolic needs pro...

    Authors: Lauren K. Park, Kian-Huat Lim, Jonas Volkman, Mina Abdiannia, Hannah Johnston, Zack Nigogosyan, Marilyn J. Siegel, Janet B. McGill, Alexis M. McKee, Maamoun Salam, Rong M. Zhang, Da Ma, Karteek Popuri, Vincent Tze Yang Chow, Mirza Faisal Beg, William G. Hawkins…
    Citation: Cancer & Metabolism 2023 11:6
  28. Glycogen storage disease type 1a (GSD Ia) is an inborn error of metabolism caused by a defect in glucose-6-phosphatase (G6PC1) activity, which induces severe hepatomegaly and increases the risk for liver cance...

    Authors: Martijn G. S. Rutten, Yu Lei, Joanne H. Hoogerland, Vincent W. Bloks, Hong Yang, Trijnie Bos, Kishore A. Krishnamurthy, Aycha Bleeker, Mirjam H. Koster, Rachel E. Thomas, Justina C. Wolters, Hilda van den Bos, Gilles Mithieux, Fabienne Rajas, Adil Mardinoglu, Diana C. J. Spierings…
    Citation: Cancer & Metabolism 2023 11:5
  29. Gene expression signatures associated with breast cancer metastases suggest that metabolic re-wiring is important for metastatic growth in lungs, bones, and other organs. However, since pathway fluxes depend o...

    Authors: Mika B. Jekabsons, Mollie Merrell, Anna G. Skubiz, Noah Thornton, Sandra Milasta, Douglas Green, Taosheng Chen, Yan-Hong Wang, Bharathi Avula, Ikhlas A. Khan and Yu-Dong Zhou
    Citation: Cancer & Metabolism 2023 11:4
  30. Recently, we reported that tamoxifen-resistant (TAM-R) breast cancer cells are cross-resistant to irradiation. Here, we investigated the mechanisms associated with tamoxifen-induced radioresistance, aiming to ...

    Authors: F. V. Naumann, F. C. G. J. Sweep, G. J. Adema, W. J. M. Peeters, J. W. M. Martens, J. Bussink and P. N. Span
    Citation: Cancer & Metabolism 2023 11:3
  31. Acute lymphoblastic leukemia (ALL) and its treatment continue to pose substantial risks. To understand ALL more deeply, the metabolome in fasting plasma of 27 ALL patients before and after high-dose methotrexa...

    Authors: Jinqiu Fu, Aijun Zhang, Qinqin Liu, Dong Li, Xiaoming Wang and Libo Si
    Citation: Cancer & Metabolism 2023 11:2
  32. Arginase-1 (ARG1), a urea cycle-related enzyme, catalyzes the hydrolysis of arginine to urea and ornithine, which regulates the proliferation, differentiation, and function of various cells. However, it is unc...

    Authors: Xiangdong Wang, Huihui Xiang, Yujiro Toyoshima, Weidong Shen, Shunsuke Shichi, Hiroki Nakamoto, Saori Kimura, Ko Sugiyama, Shigenori Homma, Yohei Miyagi, Akinobu Taketomi and Hidemitsu Kitamura
    Citation: Cancer & Metabolism 2023 11:1
  33. Pancreatic ductal adenocarcinoma (PDAC) lacks effective treatment options beyond chemotherapy. Although molecular subtypes such as classical and QM (quasi-mesenchymal)/basal-like with transcriptome-based disti...

    Authors: Irina Heid, Corinna Münch, Sinan Karakaya, Smiths S. Lueong, Alina M. Winkelkotte, Sven T. Liffers, Laura Godfrey, Phyllis F. Y. Cheung, Konstantinos Savvatakis, Geoffrey J. Topping, Florian Englert, Lukas Kritzner, Martin Grashei, Andrea Tannapfel, Richard Viebahn, Heiner Wolters…
    Citation: Cancer & Metabolism 2022 10:24
  34. Resistance to chemotherapeutic drugs is a key factor for cancer recurrence and metastases in head and neck cancer (HNC). Cancer stem cells (CSCs) in tumors have self-renewal, differentiation, and higher drug r...

    Authors: Wan-Hsuan Sun, Yun-Hsuan Chen, Hou-Hsuan Lee, Yu-Wen Tang and Kuang-Hui Sun
    Citation: Cancer & Metabolism 2022 10:23
  35. Protein arginine methyltransferase 5 (PRMT5) is upregulated in multiple tumors and plays a pivotal role in cancer cell proliferation. However, the role of PRMT5 in colorectal cancer remains poorly understood.

    Authors: Yao Shen, Pan Zhao, Kewei Dong, Jiajia Wang, Huichen Li, Mengyang Li, Ruikai Li, Suning Chen, Yuxia Shen, Zhiyu Liu, Mianjiao Xie, Peng Shen and Jian Zhang
    Citation: Cancer & Metabolism 2022 10:22
  36. Research about tumor “metabolic flexibility”—the ability of cells to toggle between preferred nutrients depending on the metabolic context—has largely focused on obesity-associated cancers. However, increasing...

    Authors: Xinyi Zhang, Alexandra A. Halberstam, Wanling Zhu, Brooks P. Leitner, Durga Thakral, Marcus W. Bosenberg and Rachel J. Perry
    Citation: Cancer & Metabolism 2022 10:21
  37. Gastric cancer (GC) is a commonly occurring human malignancy. The 5-fluorouracil (5-Fu) is a first-line anti-gastric cancer agent. However, a large number of GC patients developed 5-Fu resistance. Currently, t...

    Authors: Yan Ding, Sujie Gao, Jiabin Zheng and Xuebo Chen
    Citation: Cancer & Metabolism 2022 10:20
  38. The association between body composition and survival in rectal cancer patients is still unclear. Therefore, we aimed to evaluate the impact of computed tomography (CT)-measured body composition on survival in...

    Authors: Angeliki Kotti, Annica Holmqvist, Mischa Woisetschläger and Xiao-Feng Sun
    Citation: Cancer & Metabolism 2022 10:19
  39. Cancer-upregulated l-type amino acid transporter 1 (LAT1; SLC7A5) supplies essential amino acids to cancer cells. LAT1 substrates are not only needed for cancer rapid growth, but involved in cellular signaling. L...

    Authors: Hiroki Okanishi, Ryuichi Ohgaki, Minhui Xu, Hitoshi Endou and Yoshikatsu Kanai
    Citation: Cancer & Metabolism 2022 10:18
  40. Contrary to the “obesity paradox,” which arises from retrospective studies relying on body mass index to define obesity, epidemiologic evidence suggests central or visceral obesity is associated with a higher ...

    Authors: Spencer R. Rosario, Randall J. Smith Jr, Santosh K. Patnaik, Song Liu, Joseph Barbi and Sai Yendamuri
    Citation: Cancer & Metabolism 2022 10:17
  41. Metabolomics is a potential means for biofluid-based lung cancer detection. We conducted a non-targeted, data-driven assessment of plasma from early-stage non-small cell lung cancer (ES-NSCLC) cases versus can...

    Authors: Julian O. Kim, Robert Balshaw, Connel Trevena, Shantanu Banerji, Leigh Murphy, David Dawe, Lawrence Tan, Sadeesh Srinathan, Gordon Buduhan, Biniam Kidane, Gefei Qing, Michael Domaratzki and Michel Aliani
    Citation: Cancer & Metabolism 2022 10:16
  42. Diffuse large B cell lymphoma (DLBCL) is an aggressive subtype of non-Hodgkin lymphoma (NHL) and accounts for about a third of all NHL cases. A significant proportion (~40%) of treated DLBCL patients develop r...

    Authors: Rachana Bhatt, Dashnamoorthy Ravi, Andrew M. Evens and Biju Parekkadan
    Citation: Cancer & Metabolism 2022 10:15
  43. Clear cell renal cell carcinoma (ccRCC), the predominant subtype of kidney cancer, possesses characteristic alterations to multiple metabolic pathways, including the accumulation of cytosolic lipid droplets. H...

    Authors: Timothy D. Klasson, Edward L. LaGory, Hongjuan Zhao, Star K. Huynh, Ioanna Papandreou, Eui Jung Moon and Amato J. Giaccia
    Citation: Cancer & Metabolism 2022 10:14
  44. Breast cancer (BC) is the most commonly diagnosed cancer. Currently, mammography and breast ultrasonography are the main clinical screening methods for BC. Our study aimed to reveal the specific metabolic prof...

    Authors: Rui An, Haitao Yu, Yanzhong Wang, Jie Lu, Yuzhen Gao, Xinyou Xie and Jun Zhang
    Citation: Cancer & Metabolism 2022 10:13
  45. Growing evidence supports the use of low-carbohydrate/high-fat ketogenic diets as an adjunctive cancer therapy. However, it is unclear which genetic, metabolic, or immunological factors contribute to the benef...

    Authors: Daniela D. Weber, Sepideh Aminzadeh-Gohari, Maheshwor Thapa, Anna-Sophia Redtenbacher, Luca Catalano, Tânia Capelôa, Thibaut Vazeille, Michael Emberger, Thomas K. Felder, René G. Feichtinger, Peter Koelblinger, Guido Dallmann, Pierre Sonveaux, Roland Lang and Barbara Kofler
    Citation: Cancer & Metabolism 2022 10:12
  46. 13C tracer analysis is increasingly used to monitor cellular metabolism in vivo and in intact cells, but data interpretation is still the key element to unveil the complexity of metabolic activities. The distinct...

    Authors: Likun Duan, Daniel E. Cooper, Grace Scheidemantle, Jason W. Locasale, David G. Kirsch and Xiaojing Liu
    Citation: Cancer & Metabolism 2022 10:11
  47. Metabolic adaptations can allow cancer cells to survive DNA-damaging chemotherapy. This unmet clinical challenge is a potential vulnerability of cancer. Accordingly, there is an intense search for mechanisms t...

    Authors: Christian Marx, Jürgen Sonnemann, Oliver D. K. Maddocks, Lisa Marx-Blümel, Mandy Beyer, Doerte Hoelzer, René Thierbach, Claudia Maletzki, Michael Linnebacher, Thorsten Heinzel and Oliver H. Krämer
    Citation: Cancer & Metabolism 2022 10:10
  48. Most in vitro cancer cell experiments have been performed using 2D models. However, 3D spheroid cultures are increasingly favored for being more representative of in vivo tumor conditions. To overcome the tran...

    Authors: Tia R. Tidwell, Gro V. Røsland, Karl Johan Tronstad, Kjetil Søreide and Hanne R. Hagland
    Citation: Cancer & Metabolism 2022 10:9

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