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Figure 7 | Cancer & Metabolism

Figure 7

From: Metformin directly acts on mitochondria to alter cellular bioenergetics

Figure 7

Metformin directly acts on mitochondria and shifts the balance between coupling and uncoupling reactions. Metformin is transported into cells through the OCT family of transporters, where it acts on mitochondria to inhibit complex I-dependent respiration and increase the proportion of uncoupled respiration. Cells respond by increasing glycolysis, ultimately leading to increased lactate production.

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