Articles

Can inhibiting insulin/IGF signaling with dietary carbohydrate restriction play a role in treatment/prevention of cancers?

Authors: Eugene J Fine, C Segal-Isaacson, Silvia Herzkopf, Joseph Sparano, Maria Romano, Richard Feinman, Nora Tomuta, Amanda Bontempo and Abdissa Negassa

Influence of polyphenol-rich apple pomace extract on oxidative damage to DNA in type 2 diabetes mellitus individuals

Authors: Annemarie Grindel, Elisabeth Müllner, Helmut Brath, Walther Jäger, Trine Henriksen, Henrik Enghusen Poulsen, Doris Marko and Karl-Heinz Wagner

Dichloroacetate is an effective treatment for sarcoma models in vitro and in vivo

Authors: Melissa Rooke, Lucy A Coupland, Thy Truong and Anneke C Blackburn

Short treatment of metformin attenuated insulin resistance and hepatic steatosis in obese mice by mechanisms independents of PPAR-alpha

Authors: Alexandre Teixeira, Camila Souza, Edson Lima, Helena Batatinha and José Rosa Neto

A role for central carbon metabolism in mammalian embryonic development?

Authors: Marteinn Snaebjornsson, Nicole Prior, Vinay Bulusu, Bernd Simon, Teresa Carlomagno and Alexander Aulehla

PI 3-kinase and disease

Authors: Lewis C Cantley

Energy balance at the organism and cellular level: effects of biguanides

Authors: Michael Pollak

Profiling metabolic changes in breast cancer with targeted proteomics

Authors: Stephan Bernhardt, Devina Mitra, Zita Soons, Rainer König, Martina Vetter, Christoph Thomssen, Eva Kantelhardt, Stefan Wiemann and Ulrike Korf

Catechin-rich green tea extract increases the expression of genes of the cholesterol synthetic pathways in livers of normal diet- and high-fat diet-fed rats

Authors: Toshikazu Suzuki, Mayumi Nagata and Ayumi Takagi

Identifying metabolomic features that predict metastasis of melanoma from a primary site

Authors: Xiaolei Shi, Zeping Hu, Elena Piskounova, Michalis Agathocleous, Sean Morrison and Ralph DeBerardinis

Metformin targets the GTPase Rac1 to inhibit prostate cancer cell migration

Authors: Béatrice Dirat, Isabelle Ader, Muriel Golzio, Amel Mettouchi, Kathiane Laurent, Frédéric Larbret, Bernard Malavaud, Mireille Cormont, Emmanuel Lemichez, Jean François Tanti and Frédéric Bost

A metabolic signature of colon cancer initiating cells

Authors: Christelle Johnson, Kai-Yuan Chen, Xiaojing Liu, Pengcheng Bu, Jason Locasale and Xiling Shen

Mechanisms and consequences of hepatic regulation of mTORC1 by metformin

Authors: Jessica J Howell, Kristina Hellberg, Reuben J Shaw and Brendan D Manning

Adipose tissue homeostasis is deeply disrupted by doxorubicin treatment

Authors: Helena Batatinha, Camila Souza, Edson Lima, Maria Isabel Alonso-Vale, Maysa Cruz, Roberta Da Cunha, Fabio Lira and Jose Rosa

Resveratrol differentially regulates NAMPT and SIRT1 in hepatocarcinoma cells and primary human hepatocytes

Authors: Susanne Schuster, Melanie Penke, Theresa Gorski, Anja Barnikol-Oettler, Rolf Gebhardt, Wieland Kiess and Antje Garten

The high colon cancer risk in African Americans can be reduced by dietary modification

Authors: Stephen O’Keefe

Loss of SIRT3 leads to a compensatory shift in cellular metabolism promoting cancer cell growth

Authors: Eoin McDonnell, Olga R Ilkayeva, Robert D Stevens, Michael J Muehlbauer, James R Bain, Tomas C Becker and Matthew D Hirschey

Reductive carboxylation mediated oxidative stress defense supports anchorage independent cell growth

Authors: Lei Jiang, Matthew Mitsche, Ralph Deberardinis and Karine Smans

Radiation-induction of MMPs limited the NK-mediated anticancer immunity in lung cancer cells

Authors: Woong Heo, Young Shin Lee, Cheol Hun Son, Kwang Mo Yang, You Soo Park and Jae Ho Bae

Acetyl-coA synthetase 2 promotes acetate utilization and maintains cell growth under metabolic stress

Authors: Zachary Schug, Barrie Peck, Dylan Jones, Qifeng Zhang, Israt Alam, Tim Witney, Elizabeth Smethurst, Shaun Grosskurth, Adrian Harris, Susan Critchlow, Eric Aboagye, Michael Wakelam, Almut Schulze and Eyal Gottlieb

Mitochondrial complex I modulation targets metabolic plasticity in breast cancer cells

Authors: V Krishnan Ramanujan, Qijin Xu and Eva Biener-Ramanujan

Regulation of growth and metabolism

Authors: David M Sabatini

AMPK – roles in nutrient sensing and in cancer

Authors: D Grahame Hardie

Chemosensitization of leukemia cells through inhibition of NAMPT

Authors: Theresa Gorski, Stefanie Petzold-Quinque, Susanne Schuster, Melanie Penke, Sandy Richter, Wieland Kiess and Antje Garten

A metabolic map of hematopoietic stem cells

Authors: Michalis Agathocleous, Zeping Hu and Sean Morrison

A hypothetical means of treating or preventing cancer

Authors: Steven L McKnight

Troglitazone suppresses tumor cell growth and glutamine metabolism through a PPAR-independent mechanism

Authors: Miriam Reynolds and Brian Clem

The mitochondrial pyruvate carrier as a mediator of the Warburg Effect and its impact on cancer growth and metabolism

Authors: John Schell, Kristofor Olson and Jared Rutter

Altered cancer cell metabolism and cachexia: Calculating the energetic cost of cancer

Authors: Douglas Friesen, Vickie Baracos and Jack Tuszynski

Fructose-2,6-bisphosphate links glucose to survival and growth

Authors: Abdullah Yalcin, Yoannis Imbert-Fernandez, Amy Clem, Julie O’Neal, Sucheta Telang, Brian Clem and Jason Chesney

Investigating the role of inorganic phosphate in tumor metabolism and metastasis

Authors: Cesar Perez Ramirez and Dorothea Fiedler

Investigation of the role of Ras and other signaling kinases on the regulation of pyruvate dehydrogenase complex activity

Authors: Antonio Garcia-Trinidad, Nicky Whalley and Susan Critchlow

Inhibiting glucose-regulated protein 78 modulates lipid metabolism through controlling stearoyl-CoA desaturase 1

Authors: Katherine Cook, Pamela Clarke, Anni Warri and Robert Clarke

Metabolic reprogramming by KSHV in cellular transformation

Authors: Ying Zhu, Suzane Ramos da Silva and Shou-Jiang Gao

Extracellular lactate cooperates with limited glucose and glutamine to sustain breast cancer cell survival by providing ATP, NADPH, amino acids, and glutathione

Authors: Jennifer Molina, Pietro Morlacchi, Leslie Silva, Jennifer Dennison and Gordon Mills

Leucine supplementation differentially enhances pancreatic cancer growth in lean and overweight mice

The risk of pancreatic cancer, the 4th deadliest cancer for both men and women in the United States, is increased by obesity. Calorie restriction (CR) is a well-known dietary regimen that prevents or reverses ...

Authors: Kristyn A Liu, Laura M Lashinger, Audrey J Rasmussen and Stephen D Hursting

A strategically designed small molecule attacks alpha-ketoglutarate dehydrogenase in tumor cells through a redox process

Targeting cancer cell metabolism is recognized as a promising arena for development of cancer chemotherapeutics. Moreover, redox metabolism is also systematically altered in tumor cells. Indeed, there is growi...

Authors: Shawn D Stuart, Alexandra Schauble, Sunita Gupta, Adam D Kennedy, Brian R Keppler, Paul M Bingham and Zuzana Zachar

Q&A: Targeting metabolism to diagnose and treat cancer

Authors: Ralph J DeBerardinis

Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways

Both tumor hypoxia and dysregulated metabolism are classical features of cancer. Recent analyses have revealed complex interconnections between oncogenic activation, hypoxia signaling systems and metabolic pat...

Authors: Norma Masson and Peter J Ratcliffe

Inhibition of 6-phosphofructo-2-kinase (PFKFB3) induces autophagy as a survival mechanism

Unlike glycolytic enzymes that directly catabolize glucose to pyruvate, the family of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFKFBs) control the conversion of fructose-6-phosphate to and from f...

Authors: Alden C Klarer, Julie O’Neal, Yoannis Imbert-Fernandez, Amy Clem, Steve R Ellis, Jennifer Clark, Brian Clem, Jason Chesney and Sucheta Telang

TIGAR, TIGAR, burning bright

Cancers cells shift their metabolism towards glycolysis in order to help them support the biosynthetic demands necessary to sustain cell proliferation and growth, adapt to stress and avoid excessive reactive o...

Authors: Pearl Lee, Karen H Vousden and Eric C Cheung

Acidosis induces reprogramming of cellular metabolism to mitigate oxidative stress

A variety of oncogenic and environmental factors alter tumor metabolism to serve the distinct cellular biosynthetic and bioenergetic needs present during oncogenesis. Extracellular acidosis is a common microen...

Authors: Gregory LaMonte, Xiaohu Tang, Julia Ling-Yu Chen, Jianli Wu, Chien-Kuang Cornelia Ding, Melissa M Keenan, Carolyn Sangokoya, Hsiu-Ni Kung, Olga Ilkayeva, László G Boros, Christopher B Newgard and Jen-Tsan Chi

PGC-1α supports glutamine metabolism in breast cancer

Glutamine metabolism is a central metabolic pathway in cancer. Recently, reductive carboxylation of glutamine for lipogenesis has been shown to constitute a key anabolic route in cancer cells. However, little ...

Authors: Shawn McGuirk, Simon-Pierre Gravel, Geneviève Deblois, David J Papadopoli, Brandon Faubert, André Wegner, Karsten Hiller, Daina Avizonis, Uri David Akavia, Russell G Jones, Vincent Giguère and Julie St-Pierre

Deficiency of metabolic regulator FGFR4 delays breast cancer progression through systemic and microenvironmental metabolic alterations

Endocrine FGF21 and FGF19 target adipocytes and hepatocytes through betaKlotho (KLB) and FGFR tyrosine kinases effecting glucose, lipid and energy metabolism. Both factors alleviate obesity and metabolic abnor...

Authors: Yongde Luo, Chaofeng Yang, Min Ye, Chengliu Jin, James L Abbruzzese, Mong-Hong Lee, Sai-Ching J Yeung and Wallace L McKeehan

The metabolic demands of cancer cells are coupled to their size and protein synthesis rates

Although cells require nutrients to proliferate, most nutrient exchange rates of the NCI60 panel of cancer cell lines correlate poorly with their proliferation rate. Here, we provide evidence indicating that t...

Authors: Sonia C Dolfi, Leo Li-Ying Chan, Jean Qiu, Philip M Tedeschi, Joseph R Bertino, Kim M Hirshfield, Zoltán N Oltvai and Alexei Vazquez

Quinoline 3-sulfonamides inhibit lactate dehydrogenase A and reverse aerobic glycolysis in cancer cells

Most normal cells in the presence of oxygen utilize glucose for mitochondrial oxidative phosphorylation. In contrast, many cancer cells rapidly convert glucose to lactate in the cytosol, a process termed aerob...

Authors: Julia Billiard, Jennifer B Dennison, Jacques Briand, Roland S Annan, Deping Chai, Mariela Colón, Christopher S Dodson, Seth A Gilbert, Joel Greshock, Junping Jing, Hong Lu, Jeanelle E McSurdy-Freed, Lisa A Orband-Miller, Gordon B Mills, Chad J Quinn, Jessica L Schneck…

LKB1 is a central regulator of tumor initiation and pro-growth metabolism in ErbB2-mediated breast cancer

Germline and somatic mutations in STK11, the gene encoding the serine/threonine kinase LKB1, are strongly associated with tumorigenesis. While loss of LKB1 expression has been linked to breast cancer, the mechani...

Authors: Fanny Dupuy, Takla Griss, Julianna Blagih, Gäelle Bridon, Daina Avizonis, Chen Ling, Zhifeng Dong, Doris R Siwak, Matthew G Annis, Gordon B Mills, William J Muller, Peter M Siegel and Russell G Jones

Ets-1 global gene expression profile reveals associations with metabolism and oxidative stress in ovarian and breast cancers

The Ets-1 proto-oncogene is frequently upregulated in cancer cells, with known involvement in cancer angiogenesis, metastasis, and more recently energy metabolism. In this study we have performed various bioin...

Authors: Meghan L Verschoor, Chris P Verschoor and Gurmit Singh

Linking vitamin B1 with cancer cell metabolism

The resurgence of interest in cancer metabolism has linked alterations in the regulation and exploitation of metabolic pathways with an anabolic phenotype that increases biomass production for the replication ...

Authors: Jason A Zastre, Rebecca L Sweet, Bradley S Hanberry and Star Ye

The role of Bergmann glial cells in cerebellar development

Authors: Pierre Leprince