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  1. Content type: Oral presentation

    Authors: Zachary Schug, Barrie Peck, Dylan Jones, Qifeng Zhang, Israt Alam, Tim Witney, Elizabeth Smethurst, Shaun Grosskurth, Adrian Harris, Susan Critchlow, Eric Aboagye, Michael Wakelam, Almut Schulze and Eyal Gottlieb

    Citation: Cancer & Metabolism 2014 2(Suppl 1):O9

    Published on:

    This article is part of a Supplement: Volume 2 Supplement 1

  2. Content type: Research

    The risk of pancreatic cancer, the 4th deadliest cancer for both men and women in the United States, is increased by obesity. Calorie restriction (CR) is a well-known dietary regimen that prevents or reverses ...

    Authors: Kristyn A Liu, Laura M Lashinger, Audrey J Rasmussen and Stephen D Hursting

    Citation: Cancer & Metabolism 2014 2:6

    Published on:

  3. Content type: Research

    Targeting cancer cell metabolism is recognized as a promising arena for development of cancer chemotherapeutics. Moreover, redox metabolism is also systematically altered in tumor cells. Indeed, there is growi...

    Authors: Shawn D Stuart, Alexandra Schauble, Sunita Gupta, Adam D Kennedy, Brian R Keppler, Paul M Bingham and Zuzana Zachar

    Citation: Cancer & Metabolism 2014 2:4

    Published on:

  4. Content type: Research

    Unlike glycolytic enzymes that directly catabolize glucose to pyruvate, the family of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFKFBs) control the conversion of fructose-6-phosphate to and from f...

    Authors: Alden C Klarer, Julie O’Neal, Yoannis Imbert-Fernandez, Amy Clem, Steve R Ellis, Jennifer Clark, Brian Clem, Jason Chesney and Sucheta Telang

    Citation: Cancer & Metabolism 2014 2:2

    Published on:

  5. Content type: Review

    Cancers cells shift their metabolism towards glycolysis in order to help them support the biosynthetic demands necessary to sustain cell proliferation and growth, adapt to stress and avoid excessive reactive o...

    Authors: Pearl Lee, Karen H Vousden and Eric C Cheung

    Citation: Cancer & Metabolism 2014 2:1

    Published on:

  6. Content type: Research

    A variety of oncogenic and environmental factors alter tumor metabolism to serve the distinct cellular biosynthetic and bioenergetic needs present during oncogenesis. Extracellular acidosis is a common microen...

    Authors: Gregory LaMonte, Xiaohu Tang, Julia Ling-Yu Chen, Jianli Wu, Chien-Kuang Cornelia Ding, Melissa M Keenan, Carolyn Sangokoya, Hsiu-Ni Kung, Olga Ilkayeva, László G Boros, Christopher B Newgard and Jen-Tsan Chi

    Citation: Cancer & Metabolism 2013 1:23

    Published on:

  7. Content type: Research

    Glutamine metabolism is a central metabolic pathway in cancer. Recently, reductive carboxylation of glutamine for lipogenesis has been shown to constitute a key anabolic route in cancer cells. However, little ...

    Authors: Shawn McGuirk, Simon-Pierre Gravel, Geneviève Deblois, David J Papadopoli, Brandon Faubert, André Wegner, Karsten Hiller, Daina Avizonis, Uri David Akavia, Russell G Jones, Vincent Giguère and Julie St-Pierre

    Citation: Cancer & Metabolism 2013 1:22

    Published on:

  8. Content type: Research

    Endocrine FGF21 and FGF19 target adipocytes and hepatocytes through betaKlotho (KLB) and FGFR tyrosine kinases effecting glucose, lipid and energy metabolism. Both factors alleviate obesity and metabolic abnor...

    Authors: Yongde Luo, Chaofeng Yang, Min Ye, Chengliu Jin, James L Abbruzzese, Mong-Hong Lee, Sai-Ching J Yeung and Wallace L McKeehan

    Citation: Cancer & Metabolism 2013 1:21

    Published on:

  9. Content type: Research

    Although cells require nutrients to proliferate, most nutrient exchange rates of the NCI60 panel of cancer cell lines correlate poorly with their proliferation rate. Here, we provide evidence indicating that t...

    Authors: Sonia C Dolfi, Leo Li-Ying Chan, Jean Qiu, Philip M Tedeschi, Joseph R Bertino, Kim M Hirshfield, Zoltán N Oltvai and Alexei Vazquez

    Citation: Cancer & Metabolism 2013 1:20

    Published on:

  10. Content type: Research

    Most normal cells in the presence of oxygen utilize glucose for mitochondrial oxidative phosphorylation. In contrast, many cancer cells rapidly convert glucose to lactate in the cytosol, a process termed aerob...

    Authors: Julia Billiard, Jennifer B Dennison, Jacques Briand, Roland S Annan, Deping Chai, Mariela Colón, Christopher S Dodson, Seth A Gilbert, Joel Greshock, Junping Jing, Hong Lu, Jeanelle E McSurdy-Freed, Lisa A Orband-Miller, Gordon B Mills, Chad J Quinn, Jessica L Schneck…

    Citation: Cancer & Metabolism 2013 1:19

    Published on:

  11. Content type: Research

    Germline and somatic mutations in STK11, the gene encoding the serine/threonine kinase LKB1, are strongly associated with tumorigenesis. While loss of LKB1 expression has been linked to breast cancer, the mechani...

    Authors: Fanny Dupuy, Takla Griss, Julianna Blagih, Gäelle Bridon, Daina Avizonis, Chen Ling, Zhifeng Dong, Doris R Siwak, Matthew G Annis, Gordon B Mills, William J Muller, Peter M Siegel and Russell G Jones

    Citation: Cancer & Metabolism 2013 1:18

    Published on:

  12. Content type: Research

    The Ets-1 proto-oncogene is frequently upregulated in cancer cells, with known involvement in cancer angiogenesis, metastasis, and more recently energy metabolism. In this study we have performed various bioin...

    Authors: Meghan L Verschoor, Chris P Verschoor and Gurmit Singh

    Citation: Cancer & Metabolism 2013 1:17

    Published on:

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