Articles

Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer

Loss of the endosulfatase HSulf-1 is common in ovarian cancer, upregulates heparin binding growth factor signaling and potentiates tumorigenesis and angiogenesis. However, metabolic differences between isogeni...

Authors: Debarshi Roy, Susmita Mondal, Chen Wang, Xiaoping He, Ashwani Khurana, Shailendra Giri, Robert Hoffmann, Deok-Beom Jung, Sung H Kim, Eduardo N Chini, Juliana Camacho Periera, Clifford D Folmes, Andrea Mariani, Sean C Dowdy, Jamie N Bakkum-Gamez, Shaun M Riska…

GLUT3 is induced during epithelial-mesenchymal transition and promotes tumor cell proliferation in non-small cell lung cancer

Alterations in glucose metabolism and epithelial-mesenchymal transition (EMT) constitute two important characteristics of carcinoma progression toward invasive cancer. Despite an extensive characterization of ...

Authors: Mark Masin, Jessica Vazquez, Simona Rossi, Svenja Groeneveld, Natasha Samson, Petra C Schwalie, Bart Deplancke, Laura E Frawley, Jérôme Gouttenoire, Darius Moradpour, Trudy G Oliver and Etienne Meylan

Defects in mitochondrial metabolism and cancer

Cancer is a heterogeneous set of diseases characterized by different molecular and cellular features. Over the past decades, researchers have attempted to grasp the complexity of cancer by mapping the genetic ...

Authors: Edoardo Gaude and Christian Frezza

Decoding the dynamics of cellular metabolism and the action of 3-bromopyruvate and 2-deoxyglucose using pulsed stable isotope-resolved metabolomics

Cellular metabolism is highly dynamic and continuously adjusts to the physiological program of the cell. The regulation of metabolism appears at all biological levels: (post-) transcriptional, (post-) translat...

Authors: Matthias Pietzke, Christin Zasada, Susann Mudrich and Stefan Kempa

Mitochondria and cancer

Authors: Navdeep S Chandel

Separation of metabolic supply and demand: aerobic glycolysis as a normal physiological response to fluctuating energetic demands in the membrane

Cancer cells, and a variety of normal cells, exhibit aerobic glycolysis, high rates of glucose fermentation in the presence of normal oxygen concentrations, also known as the Warburg effect. This metabolism is...

Authors: Tamir Epstein, Liping Xu, Robert J Gillies and Robert A Gatenby

Preventing feedback activation of glycolytic ATP production enhances metformin cytotoxicity in breast cancer cells when oxidative phosphorylation is inhibited

Authors: Yongxian Zhuang, Daniel K Chan and W Keith Miskimins

The interaction of botanicals and AMPK signaling in the inhibition of castrate-resistant prostate cancer

Authors: Jay Whelan and Yi Zhao

The power of natural phenolic compounds: caffeic acid is able to enhance the retinoid-induced differentiation of tumor cells

Authors: Renata Veselska, Petr Chlapek, Miroslava Krzyzankova, Silvia Chovanova, Jakub Neradil, Karel Zitterbart and Jaroslav Sterba

Cell proliferation and tissue remodeling are major determinants of cancer metabolism and the response to drugs targeting metabolism

Authors: Elke Markert, Philip Tedeschi, Sonia Dolphi, Kim Hirshfield, Joseph Bertino, Zoltan Oltvai and Alexei Vazquez

The NADP⁺-dependent IDH1 mutation and its relevance for glioblastoma patient survival

Authors: Cornelis JF Van Noorden

Pioglitazone and thyroid cancer risk in patients with type 2 diabetes

Authors: Chin-Hsiao Tseng

Disruption of the endocannabinoid system is prominent in lung adenocarcinoma and associated with poor patient survival

Authors: Kelsie Thu, Roland Hubaux, Stephen Lam and Wan Lam

Long-term hospitalized elderly people have lowered L-carnitine and coenzyme Q₁₀ in blood than healthy elderly people

Authors: Michiyo Takahashi, Toshikazu Suzuki, Hikaru Matsumoto, Hitoshi Nukada and Naotaka Hashizume

Characterization of the different S6Ks isoforms interacting partners

Authors: Isadora Pavan, Flávia Ferreira, Lidia de Freitas, Mariana Tavares, Camila do Amaral and Fernando Simabuco

Glutamine metabolism and the unfolded protein response in MYC-driven breast cancer

Authors: Ayesha Shajahan-Haq, Katherine Cook, Jessica Schwartz-Roberts, Ahreej Eltayeb, Diane Demas, Anni Warri, Leena Hilakivi-Clarke and Robert Clarke

Mitochondria, metabolism and cancer: a growing role in cancer cell differentiation and cancer cell dormancy

Authors: Roberto Scatena, Patrizia Bottoni and Bruno Giardina

Oncogenic signaling upstream of mTORC1 drives lipogenesis and proliferation through SREBP

Authors: Stéphane Ricoult, Jessica Yecies and Brendan Manning

Pyruvate dehydrogenase activity is required for optimal growth under lipid deficient conditions

Authors: Kartik Rajagopalan and Ralph DeBerardinis

Metabolic mechanisms regulating distinct steps of the melanoma metastatic cascade

Authors: Elena Piskounova, Michalis Agathocleous, Zeping Hu and Sean Morrison

Comprehensive quantitation of metabolite concentrations, gross reaction fluxes, and reaction free energies across cells from four organisms

Authors: Junyoung Park, Sara Rubin, Yi-Fan Xu, Daniel Amador-Noguez, Jing Fan and Joshua Rabinowitz

Palmitoleate attenuates diet induced insulin resistance and hepatic inflammation independently of PPAR-α

Authors: Camila O Souza, Alexandre A de S Teixeira, Edson A de Lima, Helena A Batatinha, Sandro M Hirabara, William T Festuccia and José Cesar Rosa Neto

Metabolic transformations in breast cancer subtypes

Authors: Devina Mitra, Stephan Bernhardt, Zita Soons, Gernot Poschet, Ruediger Hell, Rainer Koenig, Ulrike Korf and Stefan Wiemann

See abstract O18

Authors:

Pancreatic cancers depend on a non-canonical glutamine metabolism pathway

Authors: Costas Lyssiotis, Jaekyoung Son, Joesph Mancias, Haoqiang Ying, Alec Kimmelman and Lewis Cantley

LC-MS and GC-MS based metabolomics platform for cancer research

Authors: Wenyun Lu, Sisi Zhang, Xin Teng, Eugene Melamud, Mitchell A Lazar, Eileen White and Joshua D Rabinowitz

Quantification of NADPH balance during adipogenesis

Authors: Ling Liu, Supriya Shah, Jing Fan, Kathryn Wellen and Joshua Rabinowitz

The Regulation of TIGAR

Authors: Pearl Lee, Eric C Cheung and Karen H Vousden

The biochemical mechanism of hypoxia-induced mobilization of glycogen in cultured cancer cell

Authors: Mung Kwan Long and Wong Nai Sum

Quantifying the demand for central carbon metabolism precursors for biosynthesis in proliferating cells

Authors: Mark Keibler, Thomas Wasylenko, Joanne Kelleher and Gregory Stephanopoulos

What cancer is teaching us about cellular metabolism

Authors: Craig B Thompson

CRTC1 transcriptional coactivator is required for hepatitis B virus gene expression and replication

Authors: Hei-Man Vincent Tang, Wei-Wei Gao, Chi-Ping Chan, Kin-Hang Kok and Dong-Yan Jin

Simultaneous inhibition of the estrogen receptor and 6-phosphofructo-2-kinase (PFKFB3) for the treatment of ER+ breast cancer

Authors: Yoannis Imbert-Fernandez, Sucheta Telang and Jason Chesney

Effects of biguanides on oxidative phosphorylation

Authors: Judy Hirst

Metformin, mitochondria and cancer

Authors: Navdeep S Chandel

Biguanide therapy for diabetes and cancer & a novel methyltransferase that regulates energy expenditure and adiposity and is elevated in many cancers

Authors: Barbara B Kahn, Daniel Kraus and Qin Yang

Metformin suppresses pediatric acute myeloid leukemia cell viability and clonogenicity

Authors: Anilkumar Gopalakrishnapillai, E Anders Kolb and Sonali Barwe

Extracts from medicinal plants inhibit cancer cell proliferation, induce apoptosis in ovary, lung and neuronal cancer cell lines

Authors: Wafa Ghali, David Vaudry, Thierry Jouenne and Mohamed Nejib Marzouki

A Drosophila model linking diet-induced metabolic disease and cancer

Authors: Susumu Hirabayashi, Thomas Baranski and Ross Cagan

Regulation of metabolism by a neuroendocrine FGF signaling pathway

Authors: David J Mangelsdorf and Steven A Kliewer

The in vivo function of TIGAR, a p53 target gene that regulates glucose metabolism

Authors: Eric Cheung, Pearl Lee, Celia Berkers, Karen Blyth, Owen Sansom and Karen Vousden

Metabolic diversity in human non-small cell lung cancer

Authors: Pei-Hsuan Chen, Ling Cai, Hyun Seok Kim, Rebecca Britt, Guanghua Xiao, Michael A White, John D Minna and Ralph J DeBerardinis

Role of autophagy in K-RAS- and B-RAF-driven lung cancers

Authors: Eileen White

¹H Nuclear magnetic resonance based targeted profiling of metabolic responses induced by DNA damaging agents and PARP inhibition in MCF-7 cells

Authors: Vijesh Bhute, Daniel Beard, Stephen Kron and Sean Palecek

Oncogenic switching of hypoxia signalling pathways

Authors: Peter J Ratcliffe

mTORC1 stimulates nucleotide synthesis through both transcriptional and post-translational mechanisms

Authors: Issam Ben-Sahra, Stephane Ricoult, Jessica Howell, John Asara and Brendan Manning

Nutrition and metabolic factors in cancer causation and prevention

Authors: Elio Riboli

Dual mode of action of metformin on mitochondrial metabolism

Authors: Sylvia Andrzejewski, Simon-Pierre Gravel, Julie St-Pierre and Michael N Pollak

Metabolic analysis of the loss of Rb1 in vivo

Authors: Brandon N Nicolay, Paul S Danielian, Wilhelm Haas, Gregory Stephanopoulos, Jacqueline A Lees and Nicholas J Dyson

Doxorubicin leads to impaired insulin signaling in skeletal muscle

Authors: Edson Alves de Lima Junior, Camila Oliveira de Souza, Alexandre Abílio de Souza Teixeira, Helena Angélica Batatinha, Fábio de Santos Lira and José César Rosa Neto