Skip to main content

Articles

Page 3 of 7

  1. We have previously identified 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], the bioactive form of vitamin D3, as a potent regulator of energy-utilization and nutrient-sensing pathways in prostate cancer cells. In the c...

    Authors: Mohamed A. Abu el Maaty, Yasamin Dabiri, Fadi Almouhanna, Biljana Blagojevic, Jannick Theobald, Michael Büttner and Stefan Wölfl
    Citation: Cancer & Metabolism 2018 6:11
  2. T cells and cancer cells utilize glycolysis for proliferation. The hexokinase (1–4) family of enzymes catalyze the first step of glycolysis. Hexokinase 2 (HK2) is one of the most highly upregulated metabolic e...

    Authors: Manan M. Mehta, Samuel E. Weinberg, Elizabeth M. Steinert, Krishan Chhiba, Carlos Alberto Martinez, Peng Gao, Harris R. Perlman, Paul Bryce, Nissim Hay and Navdeep S. Chandel
    Citation: Cancer & Metabolism 2018 6:10
  3. Inflammation, metabolism, and epigenetic modulation are highly interconnected processes that can be altered during tumorigenesis. However, because of the complexity of these interactions, direct cause and effe...

    Authors: Ashley R. Maiuri, Hongde Li, Barry D. Stein, Jason M. Tennessen and Heather M. O’Hagan
    Citation: Cancer & Metabolism 2018 6:9
  4. Precision medicine therapies require identification of unique molecular cancer characteristics. Hexokinase (HK) activity has been proposed as a therapeutic target; however, different hexokinase isoforms have n...

    Authors: Shili Xu, Arthur Catapang, Daniel Braas, Linsey Stiles, Hanna M. Doh, Jason T. Lee, Thomas G. Graeber, Robert Damoiseaux, Orian Shirihai and Harvey R. Herschman
    Citation: Cancer & Metabolism 2018 6:7
  5. Ketogenic diets (KDs) or short-term fasting are popular trends amongst supportive approaches for cancer patients. Beta-hydroxybutyrate (3-OHB) is the main physiological ketone body, whose concentration can rea...

    Authors: Catharina Bartmann, Sudha R. Janaki Raman, Jessica Flöter, Almut Schulze, Katrin Bahlke, Jana Willingstorfer, Maria Strunz, Achim Wöckel, Rainer J. Klement, Michaela Kapp, Cholpon S. Djuzenova, Christoph Otto and Ulrike Kämmerer
    Citation: Cancer & Metabolism 2018 6:8
  6. Alternative splicing of the Pkm gene product generates the PKM1 and PKM2 isoforms of the glycolytic enzyme pyruvate kinase. PKM2 expression is associated with embryogenesis, tissue regeneration, and cancer. PKM2 ...

    Authors: Talya L. Dayton, Vasilena Gocheva, Kathryn M. Miller, Arjun Bhutkar, Caroline A. Lewis, Roderick T. Bronson, Matthew G. Vander Heiden and Tyler Jacks
    Citation: Cancer & Metabolism 2018 6:6
  7. There is considerable interest in defining the metabolic abnormalities of IDH mutant tumors to exploit for therapy. While most studies have attempted to discern function by using cell lines transduced with exo...

    Authors: Matthew Garrett, Jantzen Sperry, Daniel Braas, Weihong Yan, Thuc M. Le, Jack Mottahedeh, Kirsten Ludwig, Ascia Eskin, Yue Qin, Rachelle Levy, Joshua J. Breunig, Frank Pajonk, Thomas G. Graeber, Caius G. Radu, Heather Christofk, Robert M. Prins…
    Citation: Cancer & Metabolism 2018 6:4
  8. The complex yet interrelated connections between cancer metabolism and oncogenic driver genes are relatively unexplored but have the potential to identify novel biomarkers and drug targets with prognostic and ...

    Authors: Chen Dai, Jennifer Arceo, James Arnold, Arun Sreekumar, Norman J. Dovichi, Jun Li and Laurie E. Littlepage
    Citation: Cancer & Metabolism 2018 6:5
  9. Magnetic resonance spectroscopy (MRS) studies have identified elevated levels of the phospholipid precursor phosphocholine (PC) and phosphoethanolamine (PE) as metabolic hallmarks of cancer. Unusually, however...

    Authors: Pavithra Viswanath, Marina Radoul, Jose Luis Izquierdo-Garcia, Hema Artee Luchman, J. Gregory Cairncross, Russell O. Pieper, Joanna J. Phillips and Sabrina M. Ronen
    Citation: Cancer & Metabolism 2018 6:3
  10. Obesity is associated with increased risk, poor prognosis and outcome of therapy, in various cancers. Obesity-associated factors or adipokines, especially leptin and resistin, are purported to promote growth, ...

    Authors: Parmanand Malvi, Balkrishna Chaube, Shivendra Vikram Singh, Naoshad Mohammad, Maleppillil Vavachan Vijayakumar, Snahlata Singh, Surbhi Chouhan and Manoj Kumar Bhat
    Citation: Cancer & Metabolism 2018 6:2
  11. Inhibitors of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in NAD+ biosynthesis from nicotinamide, exhibit anticancer effects in preclinical models. However, continuous exposure to NAM...

    Authors: Natthakan Thongon, Chiara Zucal, Vito Giuseppe D’Agostino, Toma Tebaldi, Silvia Ravera, Federica Zamporlini, Francesco Piacente, Ruxanda Moschoi, Nadia Raffaelli, Alessandro Quattrone, Alessio Nencioni, Jean-Francois Peyron and Alessandro Provenzani
    Citation: Cancer & Metabolism 2018 6:1
  12. Folate-dependent one-carbon metabolism provides one-carbon units for several biological processes. This pathway is highly compartmentalized in eukaryotes, with the mitochondrial pathway producing formate for u...

    Authors: Minhye Shin, Jessica Momb and Dean R. Appling
    Citation: Cancer & Metabolism 2017 5:11
  13. Cancer cells express the M2 isoform of the glycolytic enzyme pyruvate kinase (PKM2). PKM2 expression is not required for some cancers, and PKM2 loss can promote cancer progression; however, PKM2 has been repor...

    Authors: Allison N. Lau, William J. Israelsen, Jatin Roper, Mark J. Sinnamon, Larissa Georgeon, Talya L. Dayton, Alissandra L. Hillis, Omer H. Yilmaz, Dolores Di Vizio, Kenneth E. Hung and Matthew G. Vander Heiden
    Citation: Cancer & Metabolism 2017 5:10
  14. Cancer cells that enter the metastatic cascade require traits that allow them to survive within the circulation and colonize distant organ sites. As disseminating cancer cells adapt to their changing microenvi...

    Authors: Caroline H. Johnson, Antonio F. Santidrian, Sarah E. LeBoeuf, Michael E. Kurczy, Nicholas J. W. Rattray, Zahra Rattray, Benedikt Warth, Melissa Ritland, Linh T. Hoang, Celine Loriot, Jason Higa, James E. Hansen, Brunhilde H. Felding and Gary Siuzdak
    Citation: Cancer & Metabolism 2017 5:9
  15. The proteasome inhibitor bortezomib (BTZ) is successfully applied in the treatment of multiple myeloma, but its efficacy is restricted by the wide-spread occurrence of resistance. Metabolic alterations play an...

    Authors: Esther A. Zaal, Wei Wu, Gerrit Jansen, Sonja Zweegman, Jacqueline Cloos and Celia R. Berkers
    Citation: Cancer & Metabolism 2017 5:7
  16. Among breast cancers, the triple-negative breast cancer (TNBC) subtype has the worst prognosis with no approved targeted therapies and only standard chemotherapy as the backbone of systemic therapy. Unique met...

    Authors: Nathan J. Lanning, Joshua P. Castle, Simar J. Singh, Andre N. Leon, Elizabeth A. Tovar, Amandeep Sanghera, Jeffrey P. MacKeigan, Fabian V. Filipp and Carrie R. Graveel
    Citation: Cancer & Metabolism 2017 5:6
  17. A key feature of clear cell renal cell carcinoma (ccRCC) is the inactivation of the von Hippel-Lindau tumour suppressor protein (pVHL) that leads to the activation of hypoxia-inducible factor (HIF) pathway als...

    Authors: Petra Miikkulainen, Heidi Högel, Krista Rantanen, Tomi Suomi, Petri Kouvonen, Laura L. Elo and Panu M. Jaakkola
    Citation: Cancer & Metabolism 2017 5:5
  18. Ketone bodies have both metabolic and epigenetic roles in cancer. In several studies, they showed an anti-cancer effect via inhibition of histone deacetylases; however, other studies observed faster tumour gro...

    Authors: Loreta M. Rodrigues, Santiago Uribe-Lewis, Basetti Madhu, Davina J. Honess, Marion Stubbs and John R. Griffiths
    Citation: Cancer & Metabolism 2017 5:4
  19. Deregulated metabolism is a well-established hallmark of cancer. At the hub of various metabolic pathways deeply integrated within mitochondrial functions, the α-ketoglutarate dehydrogenase complex represents ...

    Authors: Renaud Vatrinet, Giulia Leone, Monica De Luise, Giulia Girolimetti, Michele Vidone, Giuseppe Gasparre and Anna Maria Porcelli
    Citation: Cancer & Metabolism 2017 5:3
  20. Pancreatic cancer has a five-year survival rate of ~8%, with characteristic molecular heterogeneity and restricted treatment options. Targeting metabolism has emerged as a potentially effective therapeutic str...

    Authors: Rae-Anne Hardie, Ellen van Dam, Mark Cowley, Ting-Li Han, Seher Balaban, Marina Pajic, Mark Pinese, Mary Iconomou, Robert F. Shearer, Jessie McKenna, David Miller, Nicola Waddell, John V. Pearson, Sean M. Grimmond, Leonid Sazanov, Andrew V. Biankin…
    Citation: Cancer & Metabolism 2017 5:2
  21. Obesity is associated with increased recurrence and reduced survival of breast cancer. Adipocytes constitute a significant component of breast tissue, yet their role in provisioning metabolic substrates to sup...

    Authors: Seher Balaban, Robert F. Shearer, Lisa S. Lee, Michelle van Geldermalsen, Mark Schreuder, Harrison C. Shtein, Rose Cairns, Kristen C. Thomas, Daniel J. Fazakerley, Thomas Grewal, Jeff Holst, Darren N. Saunders and Andrew J. Hoy
    Citation: Cancer & Metabolism 2017 5:1
  22. Understanding the biologic mechanisms underlying the development of lethal prostate cancer is critical for improved therapeutic and prevention strategies. In this study we explored the role of tumor metabolism...

    Authors: Rachel S. Kelly, Jennifer A. Sinnott, Jennifer R. Rider, Ericka M. Ebot, Travis Gerke, Michaela Bowden, Andreas Pettersson, Massimo Loda, Howard D. Sesso, Philip W. Kantoff, Neil E. Martin, Edward L. Giovannucci, Svitlana Tyekucheva, Matthew Vander Heiden and Lorelei A. Mucci
    Citation: Cancer & Metabolism 2016 4:22
  23. Obesity-related cellular, metabolic, and molecular alterations have been shown to increase cancer risk and tumor progression and are associated with poorer therapeutic outcome in cancer patients. However, the ...

    Authors: Parmanand Malvi, Balkrishna Chaube, Shivendra Vikram Singh, Naoshad Mohammad, Vimal Pandey, Maleppillil Vavachan Vijayakumar, Revathy Meenatheril Radhakrishnan, Muralidharan Vanuopadath, Sudarslal Sadasivan Nair, Bipin Gopalakrishnan Nair and Manoj Kumar Bhat
    Citation: Cancer & Metabolism 2016 4:21
  24. Pancreatic ductal adenocarcinoma (PDAC) is a common malignancy with dismal prognosis. Metastatic spread and therapeutic resistance, the main causes of PDAC-related mortalities, are both partially underlined by...

    Authors: Menghan Liu, Lake-Ee Quek, Ghazal Sultani and Nigel Turner
    Citation: Cancer & Metabolism 2016 4:19
  25. There is increasing evidence that oncogenic Wnt signaling directs metabolic reprogramming of cancer cells to favor aerobic glycolysis or Warburg metabolism. In colon cancer, this reprogramming is due to direct...

    Authors: Stephanie Sprowl-Tanio, Amber N. Habowski, Kira T. Pate, Miriam M. McQuade, Kehui Wang, Robert A. Edwards, Felix Grun, Yung Lyou and Marian L. Waterman
    Citation: Cancer & Metabolism 2016 4:20
  26. Calorie restriction (CR) prevents obesity and exerts anticancer effects in many preclinical models. CR is also increasingly being used in cancer patients as a sensitizing strategy prior to chemotherapy regimen...

    Authors: Laura M. Lashinger, Ciara H. O’Flanagan, Sarah M. Dunlap, Audrey J. Rasmussen, Shannon Sweeney, Jessie Yangxiang Guo, Alessia Lodi, Stefano Tiziani, Eileen White and Stephen D. Hursting
    Citation: Cancer & Metabolism 2016 4:18
  27. Acetyl-CoA is a key metabolic intermediate with roles in the production of energy and biomass, as well as in metabolic regulation. It was recently found that acetate is crucial for maintaining acetyl-CoA produ...

    Authors: Sergey Tumanov, Vinay Bulusu, Eyal Gottlieb and Jurre J. Kamphorst
    Citation: Cancer & Metabolism 2016 4:17
  28. The study of cancer metabolism has been largely dedicated to exploring the hypothesis that oncogenic transformation rewires cellular metabolism to sustain elevated rates of growth and division. Intense examina...

    Authors: Mark A. Keibler, Thomas M. Wasylenko, Joanne K. Kelleher, Othon Iliopoulos, Matthew G. Vander Heiden and Gregory Stephanopoulos
    Citation: Cancer & Metabolism 2016 4:16
  29. The role of anaplerotic nutrient entry into the Krebs cycle via pyruvate carboxylase has been the subject of increased scrutiny and in particular whether this is dysregulated in cancer. Here, we use a tracer-b...

    Authors: Michelle A. C. Reed, Christian Ludwig, Christopher M. Bunce, Farhat L. Khanim and Ulrich L. Günther
    Citation: Cancer & Metabolism 2016 4:15
  30. Molecular profiling studies of tumor tissue from patients with clear cell renal cell cancer (ccRCC) have revealed extensive metabolic reprogramming in this disease. Associations were found between metabolic re...

    Authors: Johannes C. van der Mijn, David J. Panka, Andrew K. Geissler, Henk. M. Verheul and James W. Mier
    Citation: Cancer & Metabolism 2016 4:14
  31. Glucose and glutamine are the two dominant metabolic substrates in cancer cells. In 13C tracer experiments, however, it is necessary to account for all significant input substrates, as some natural (unlabelled) s...

    Authors: Lake-Ee Quek, Menghan Liu, Sanket Joshi and Nigel Turner
    Citation: Cancer & Metabolism 2016 4:13
  32. The heterogeneous biology of breast cancer leads to high diversity in prognosis and response to treatment, even for patients with similar clinical diagnosis, histology, and stage of disease. Identifying mechan...

    Authors: Tonje H. Haukaas, Leslie R. Euceda, Guro F. Giskeødegård, Santosh Lamichhane, Marit Krohn, Sandra Jernström, Miriam R. Aure, Ole C. Lingjærde, Ellen Schlichting, Øystein Garred, Eldri U. Due, Gordon B. Mills, Kristine K. Sahlberg, Anne-Lise Børresen-Dale and Tone F. Bathen
    Citation: Cancer & Metabolism 2016 4:12
  33. Colorectal cancers (CRC) are associated with perturbations in cellular amino acids, nucleotides, pentose-phosphate pathway carbohydrates, and glycolytic, gluconeogenic, and tricarboxylic acid intermediates. A ...

    Authors: Dustin G. Brown, Sangeeta Rao, Tiffany L. Weir, Joanne O’Malia, Marlon Bazan, Regina J. Brown and Elizabeth P. Ryan
    Citation: Cancer & Metabolism 2016 4:11
  34. Gleason scores (GS) 3+3 and 3+4 prostate cancers (PCa) differ greatly in their clinical courses, with Gleason pattern (GP) 4 representing a major independent risk factor for cancer progression. However, Gleaso...

    Authors: Ilinca Georgescu, Robert J. Gooding, R. Christopher Doiron, Andrew Day, Shamini Selvarajah, Chris Davidson, David M. Berman and Paul C. Park
    Citation: Cancer & Metabolism 2016 4:8
  35. The majority of cancer cells have a unique metabolic requirement for methionine that is not observed in normal, non-tumorigenic cells. This phenotype is described as “methionine dependence” or “methionine stre...

    Authors: Stacey L. Borrego, Johannes Fahrmann, Rupsa Datta, Chiara Stringari, Dmitry Grapov, Michael Zeller, Yumay Chen, Ping Wang, Pierre Baldi, Enrico Gratton, Oliver Fiehn and Peter Kaiser
    Citation: Cancer & Metabolism 2016 4:9
  36. Metabolism gained increasing interest for the understanding of diseases and to pinpoint therapeutic intervention points. However, classical metabolomics techniques only provide a very static view on metabolism...

    Authors: Daniel Weindl, Thekla Cordes, Nadia Battello, Sean C. Sapcariu, Xiangyi Dong, Andre Wegner and Karsten Hiller
    Citation: Cancer & Metabolism 2016 4:10
  37. The effect of moderately elevated blood glucose levels among non-diabetic subjects on cancer prognosis is not well described. The goal of this study was to examine the association of elevated random blood gluc...

    Authors: Behjatolah Monzavi-Karbassi, Rhonda Gentry, Varinder Kaur, Eric R. Siegel, Fariba Jousheghany, Srikanth Medarametla, Barbara J. Fuhrman, A. Mazin Safar, Laura F. Hutchins and Thomas Kieber-Emmons
    Citation: Cancer & Metabolism 2016 4:7
  38. Enhanced macromolecule biosynthesis is integral to growth and proliferation of cancer cells. Lipid biosynthesis has been predicted to be an essential process in cancer cells. However, it is unclear which enzym...

    Authors: Barrie Peck, Zachary T. Schug, Qifeng Zhang, Beatrice Dankworth, Dylan T. Jones, Elizabeth Smethurst, Rachana Patel, Susan Mason, Ming Jiang, Rebecca Saunders, Michael Howell, Richard Mitter, Bradley Spencer-Dene, Gordon Stamp, Lynn McGarry, Daniel James…
    Citation: Cancer & Metabolism 2016 4:6
  39. Genome scale data on biological systems has increasingly become available by sequencing of DNA and RNA, and by mass spectrometric quantification of proteins and metabolites. The cellular components from which ...

    Authors: Joerg Martin Buescher and Edward M Driggers
    Citation: Cancer & Metabolism 2016 4:4
  40. Hypoxia and inflammation have been identified as hallmarks of cancer. A majority of hepatocellular carcinomas are preceded by hepatitis B- or C-related chronic infections suggesting that liver cancer developme...

    Authors: Nadia Battello, Andreas David Zimmer, Carole Goebel, Xiangyi Dong, Iris Behrmann, Claude Haan, Karsten Hiller and Andre Wegner
    Citation: Cancer & Metabolism 2016 4:3
  41. Major contributions of the 2nd annual meeting of the International Society of Cancer Metabolism, held in Venice, September 16–19, 2015, are here described and discussed. Among these, the impact of cancer metab...

    Authors: Nicola Baldini, Pierre Sonveaux, Angelo De Milito, Claudiu T. Supuran, Angela M. Otto, Christian M. Stock, Stine F. Pedersen, Rosy Favicchio and Sofia Avnet
    Citation: Cancer & Metabolism 2016 4(Suppl 1):1

    This article is part of a Supplement: Volume 4 Supplement 1

  42. Metabolism is essential for life, and its alteration is implicated in multiple human diseases. The transformation from a normal to a cancerous cell requires metabolic changes to fuel the high metabolic demands...

    Authors: Elke Katrin Markert and Alexei Vazquez
    Citation: Cancer & Metabolism 2015 3:14
  43. Two-hydroxyglutarate (2HG) is present at low concentrations in healthy mammalian cells as both an L and D enantiomer. Both the L and D enantiomers have been implicated in regulating cellular physiology by mech...

    Authors: Susan J. Gelman, Nathaniel G. Mahieu, Kevin Cho, Elizabeth M. Llufrio, Timothy A. Wencewicz and Gary J. Patti
    Citation: Cancer & Metabolism 2015 3:13
  44. Numerous studies have demonstrated that functional mitochondria are required for tumorigenesis, suggesting that mitochondrial oxidative phosphorylation (OXPHOS) might be a potential target for cancer therapy. ...

    Authors: Laura Schöckel, Andrea Glasauer, Farhan Basit, Katharina Bitschar, Hoa Truong, Gerrit Erdmann, Carolyn Algire, Andrea Hägebarth, Peter HGM Willems, Charlotte Kopitz, Werner JH Koopman and Mélanie Héroult
    Citation: Cancer & Metabolism 2015 3:11
  45. Pancreatic ductal adenocarcinomas (PDA) activate a glutamine-dependent pathway of cytosolic nicotinamide adenine dinucleotide phosphate (NADPH) production to maintain redox homeostasis and support proliferatio...

    Authors: Gaurab Chakrabarti, Zachary R. Moore, Xiuquan Luo, Mariya Ilcheva, Aktar Ali, Mahesh Padanad, Yunyun Zhou, Yang Xie, Sandeep Burma, Pier P. Scaglioni, Lewis C. Cantley, Ralph J. DeBerardinis, Alec C. Kimmelman, Costas A. Lyssiotis and David A. Boothman
    Citation: Cancer & Metabolism 2015 3:12
  46. Glucose metabolism links metabolic status to protein acetylation. However, it remains poorly understood to what extent do features of glucose metabolism contribute to protein acetylation and whether the proces...

    Authors: Ahmad A. Cluntun, He Huang, Lunzhi Dai, Xiaojing Liu, Yingming Zhao and Jason W. Locasale
    Citation: Cancer & Metabolism 2015 3:10
  47. In recent years, advances in metabolic imaging have become dependable tools for the diagnosis and treatment assessment in cancer. Dynamic nuclear polarization (DNP) has recently emerged as a promising technolo...

    Authors: Lucia Salamanca-Cardona and Kayvan R. Keshari
    Citation: Cancer & Metabolism 2015 3:9

Annual Journal Metrics

  • Speed
    15 days to first decision for all manuscripts
    79 days to first decision for reviewed manuscripts only
    200 days from submission to acceptance
    47 days from acceptance to publication

    Citation Impact

    5.469 - 2 Year Impact Factor
    8.308 - 5 Year Impact Factor 

    Usage 
    247,017 Downloads (2021)
    553 Altmetric Mentions

Springer Nature Oncology Portfolio

Discover the range of academic oncology titles at Springer Nature here.