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  1. Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M; PCK2) is expressed in all cancer types examined and in neuroprogenitor cells. The gene is upregulated by amino acid limitation and ER-stress in an ATF4...

    Authors: Petra Hyroššová, Marc Aragó, Juan Moreno-Felici, Xiarong Fu, Andrés Mendez-Lucas, Pablo M. García-Rovés, Shawn Burgess, Agnès Figueras, Francesc Viñals and Jose C. Perales
    Citation: Cancer & Metabolism 2021 9:1
  2. Overexpression of c-Myc is required for the progression of pre-malignant plasma cells in monoclonal gammopathy of undetermined significance (MGUS) to malignant plasma cells in multiple myeloma (MM). c-Myc also...

    Authors: Wilson I. Gonsalves, Jin Sung Jang, Erik Jessen, Taro Hitosugi, Laura A. Evans, Dragan Jevremovic, Xuan-Mai Pettersson, Alexander Graham Bush, Jaimee Gransee, Emilie I. Anderson, Shaji K. Kumar and K. Sreekumaran Nair
    Citation: Cancer & Metabolism 2020 8:29
  3. Of the genes that control mitochondrial biogenesis and function, ERRα emerges as a druggable metabolic target to be exploited for cancer therapy. Of the genes mutated in cancer, TP53 remains the most elusive to t...

    Authors: Humberto De Vitto, Joohyun Ryu, Ali Calderon-Aparicio, Josh Monts, Raja Dey, Abhijit Chakraborty, Mee-Hyun Lee, Ann M. Bode and Zigang Dong
    Citation: Cancer & Metabolism 2020 8:28
  4. Protein synthesis is regulated by the availability of amino acids, the engagement of growth factor signaling pathways, and adenosine triphosphate (ATP) levels sufficient to support translation. Crosstalk betwe...

    Authors: Blake R. Wilde, Mohan R. Kaadige, Katrin P. Guillen, Andrew Butterfield, Bryan E. Welm and Donald E. Ayer
    Citation: Cancer & Metabolism 2020 8:27
  5. Aspartate biosynthesis and its delivery to the cytosol can be crucial for tumor growth in vivo. However, the impact of intracellular aspartate levels on metastasis has not been studied. We previously described th...

    Authors: H. Furkan Alkan, Paul W. Vesely, Hubert Hackl, Johannes Foßelteder, Daniel R. Schmidt, Matthew G. Vander Heiden, Martin Pichler, Gerald Hoefler and Juliane G. Bogner-Strauss
    Citation: Cancer & Metabolism 2020 8:26
  6. Deregulated lipid metabolism is common in cancer cells and the mevalonate pathway, which synthesizes cholesterol, is central in lipid metabolism. This study aimed to assess statin-induced changes of the intrat...

    Authors: Maria Feldt, Julien Menard, Ann H. Rosendahl, Barbara Lettiero, Pär-Ola Bendahl, Mattias Belting and Signe Borgquist
    Citation: Cancer & Metabolism 2020 8:25
  7. Glioblastoma (GBM) has poor survival with standard treatment. Experimental data suggest potential for metabolic treatment with low carbohydrate ketogenic diet (KD). Few human studies of KD in GBM have been don...

    Authors: Pavel Klein, Ivana Tyrlikova, Giulio Zuccoli, Adam Tyrlik and Joseph C. Maroon
    Citation: Cancer & Metabolism 2020 8:24
  8. Targeting glutamine metabolism in cancer has become an increasingly vibrant area of research. Mutant IDH1 (IDH1mut) gliomas are considered good candidates for targeting this pathway because of the contribution of...

    Authors: Victor Ruiz-Rodado, Adrian Lita, Tyrone Dowdy, Orieta Celiku, Alejandra Cavazos Saldana, Herui Wang, Chun Zhang Yang, Raj Chari, Aiguo Li, Wei Zhang, Hua Song, Meili Zhang, Susie Ahn, Dionne Davis, Xiang Chen, Zhengping Zhuang…
    Citation: Cancer & Metabolism 2020 8:23
  9. Rewiring of metabolism induced by oncogenic K-Ras in cancer cells involves both glucose and glutamine utilization sustaining enhanced, unrestricted growth. The development of effective anti-cancer treatments targ...

    Authors: Daniela Gaglio, Marcella Bonanomi, Silvia Valtorta, Rohit Bharat, Marilena Ripamonti, Federica Conte, Giulia Fiscon, Nicole Righi, Elisabetta Napodano, Federico Papa, Isabella Raccagni, Seth J. Parker, Ingrid Cifola, Tania Camboni, Paola Paci, Anna Maria Colangelo…
    Citation: Cancer & Metabolism 2020 8:22
  10. Overweight or obesity has been evidenced as an important risk factor involved in the incidence, mortality, and therapy response of multiple malignancies. However, the differences between healthy and obesity tu...

    Authors: Chao Hu, Xiong Chen, Chengyun Yao, Yu Liu, Haojun Xu, Guoren Zhou, Hongping Xia and Jinglin Xia
    Citation: Cancer & Metabolism 2020 8:21
  11. Mitochondrial serine catabolism to formate induces a metabolic switch to a hypermetabolic state with high rates of glycolysis, purine synthesis and pyrimidine synthesis. While formate is a purine precursor, it...

    Authors: Jacqueline Tait-Mulder, Kelly Hodge, David Sumpton, Sara Zanivan and Alexei Vazquez
    Citation: Cancer & Metabolism 2020 8:20
  12. Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant forms of cancer. Lack of effective treatment options and drug resistance contributes to the low survival among PDAC patients. In this study,...

    Authors: Neha Sharma, Alok Bhushan, Jun He, Gagan Kaushal and Vikas Bhardwaj
    Citation: Cancer & Metabolism 2020 8:19
  13. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Masahiro Kawashima, Karim Bensaad, Christos E. Zois, Alessandro Barberis, Esther Bridges, Simon Wigfield, Christoffer Lagerholm, Ruslan I. Dmitriev, Mariko Tokiwa, Masakazu Toi, Dmitri B. Papkovsky, Francesca M. Buffa and Adrian L. Harris
    Citation: Cancer & Metabolism 2020 8:18

    The original article was published in Cancer & Metabolism 2020 8:13

  14. Glioblastoma (GBM) are highly heterogeneous on the cellular and molecular basis. It has been proposed that glutamine metabolism of primary cells established from human tumors discriminates aggressive mesenchym...

    Authors: Kristell Oizel, Chendong Yang, Ophelie Renoult, Fabien Gautier, Quyen N. Do, Noemie Joalland, Xiaofei Gao, Bookyung Ko, François Vallette, Woo-Ping Ge, François Paris, Ralph J. DeBerardinis and Claire Pecqueur
    Citation: Cancer & Metabolism 2020 8:9
  15. The loss-of-function mutation of fumarate hydratase (FH) is a driver of hereditary leiomyomatosis and renal cell carcinoma (HLRCC). Fumarate accumulation results in activation of stress-related mechanisms lead...

    Authors: Rony Panarsky, Daniel R. Crooks, Andrew N. Lane, Youfeng Yang, Teresa A. Cassel, Teresa W.-M. Fan, W. Marston Linehan and Jeffrey A. Moscow
    Citation: Cancer & Metabolism 2020 8:7
  16. During breast cancer progression, the epithelial to mesenchymal transition has been associated with metastasis and endocrine therapy resistance; however, the underlying mechanisms remain elusive. To gain insig...

    Authors: Tamara Fernández-Calero, Marcos Davyt, Karen Perelmuter, Cora Chalar, Giovana Bampi, Helena Persson, Juan Pablo Tosar, Völundur Hafstað, Hugo Naya, Carlos Rovira, Mariela Bollati-Fogolín, Ricardo Ehrlich, Gilles Flouriot, Zoya Ignatova and Mónica Marín
    Citation: Cancer & Metabolism 2020 8:8
  17. ErbB2 breast cancer still remains an unmet need due to primary and/or acquired resistance to current treatment strategies. MEDICA compounds consist of synthetic long-chain α,ω-dicarboxylic acids previously rep...

    Authors: Sophia Eldad, Rachel Hertz, Gilad Vainer, Ann Saada and Jacob Bar-Tana
    Citation: Cancer & Metabolism 2020 8:17
  18. Obesity and metabolic syndrome are strongly associated with cancer, and these disorders may share a common mechanism. Recently, fructose has emerged as a driving force to develop obesity and metabolic syndrome...

    Authors: Takahiko Nakagawa, Miguel A. Lanaspa, Inigo San Millan, Mehdi Fini, Christopher J. Rivard, Laura G. Sanchez-Lozada, Ana Andres-Hernando, Dean R. Tolan and Richard J. Johnson
    Citation: Cancer & Metabolism 2020 8:16
  19. Humans produce heat through non-shivering thermogenesis, a metabolic process that occurs in inducible beige adipocytes expressing uncoupling protein 1 (UCP1). UCP1 dissipates the proton gradient of the mitocho...

    Authors: Masahiro Kawashima, Karim Bensaad, Christos E. Zois, Alessandro Barberis, Esther Bridges, Simon Wigfield, Christoffer Lagerholm, Ruslan I. Dmitriev, Mariko Tokiwa, Masakazu Toi, Dmitri B. Papkovsky, Francesca M. Buffa and Adrian L. Harris
    Citation: Cancer & Metabolism 2020 8:13

    The Correction to this article has been published in Cancer & Metabolism 2020 8:18

  20. The treatment of diffuse large B-cell lymphoma (DLBCL) is limited by the development of resistance to therapy, and there is a need to develop novel therapeutic strategies for relapsed and refractory aggressive...

    Authors: Anil R. Singh, Juan J. Gu, Qunling Zhang, Pallawi Torka, Suchitra Sundaram, Cory Mavis and Francisco J. Hernandez-Ilizaliturri
    Citation: Cancer & Metabolism 2020 8:10
  21. In 2006, a new model of invasive breast tumor emerged and, since 2011, is gaining recognition and research momentum. “Tumor-associated collagen signatures” describe 3 distinct layers of collagen which radiate ...

    Authors: Elizabeth A. Brett, Matthias A. Sauter, Hans-Günther Machens and Dominik Duscher
    Citation: Cancer & Metabolism 2020 8:14
  22. Metabolic reprograming, non-mutational epigenetic changes, increased cell plasticity, and multidrug tolerance are early hallmarks of therapy resistance in cancer. In this temporary, therapy-tolerant state, can...

    Authors: Kaylyn D. Tousignant, Anja Rockstroh, Berwyck L. J. Poad, Ali Talebi, Reuben S. E. Young, Atefeh Taherian Fard, Rajesh Gupta, Tuo Zang, Chenwei Wang, Melanie L. Lehman, Johan V. Swinnen, Stephen J. Blanksby, Colleen C. Nelson and Martin C. Sadowski
    Citation: Cancer & Metabolism 2020 8:11
  23. d-3-phosphoglycerate dehydrogenase (PHGDH), which encodes the first enzyme in serine biosynthesis, is overexpressed in human cancers and has been proposed as a drug target. However, whether PHGDH is critical fo.....

    Authors: Yun Pyo Kang, Aimee Falzone, Min Liu, Paloma González-Sánchez, Bo-Hyun Choi, Jonathan L. Coloff, James J. Saller, Florian A. Karreth and Gina M. DeNicola
    Citation: Cancer & Metabolism 2020 8:6
  24. Tumor initiation and progression are associated with numerous metabolic alterations. However, the biochemical drivers and constraints that contribute to metabolic gene dysregulation are unclear.

    Authors: Krishnadev Oruganty, Scott Edward Campit, Sainath Mamde, Costas A. Lyssiotis and Sriram Chandrasekaran
    Citation: Cancer & Metabolism 2020 8:5
  25. High glycolytic rate is a hallmark of cancer (Warburg effect). Glycolytic ATP is required for fuelling plasma membrane calcium ATPases (PMCAs), responsible for extrusion of cytosolic calcium, in pancreatic duc...

    Authors: D. A. Richardson, P. Sritangos, A. D. James, A. Sultan and J. I. E. Bruce
    Citation: Cancer & Metabolism 2020 8:2
  26. Osteosarcoma (OS) is a malignant bone tumor that often develops during the period of rapid growth associated with adolescence. Despite successful primary tumor control accompanied by adjuvant chemotherapy, dea...

    Authors: L. Ren, V. Ruiz-Rodado, T. Dowdy, S. Huang, S. H. Issaq, J. Beck, H. Wang, C. Tran Hoang, A. Lita, M. Larion and A. K. LeBlanc
    Citation: Cancer & Metabolism 2020 8:4
  27. Colorectal cancer (CRC) is a complex multifactorial disease. Increasing evidence suggests that the microbiome is involved in different stages of CRC initiation and progression. Beyond specific pro-oncogenic me...

    Authors: Daniel R. Garza, Rahwa Taddese, Jakob Wirbel, Georg Zeller, Annemarie Boleij, Martijn A. Huynen and Bas E. Dutilh
    Citation: Cancer & Metabolism 2020 8:3
  28. Metabolic programs in cancer cells are influenced by genotype and the tissue of origin. We have previously shown that central carbon metabolism is rewired in pancreatic ductal adenocarcinoma (PDA) to support p...

    Authors: Barbara S. Nelson, Lin Lin, Daniel M. Kremer, Cristovão M. Sousa, Cecilia Cotta-Ramusino, Amy Myers, Johanna Ramos, Tina Gao, Ilya Kovalenko, Kari Wilder-Romans, Joseph Dresser, Mary Davis, Ho-Joon Lee, Zeribe C. Nwosu, Scott Campit, Oksana Mashadova…
    Citation: Cancer & Metabolism 2020 8:1
  29. Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with limited treatment options. Pyruvate kinase, especially the M2 isoform (PKM2), is highly expressed in PDAC cells, but its role in pancreatic ...

    Authors: Lei Yu, Shao Thing Teoh, Elliot Ensink, Martin P. Ogrodzinski, Che Yang, Ana I. Vazquez and Sophia Y. Lunt
    Citation: Cancer & Metabolism 2019 7:13
  30. Hypoxia-inducible factors (HIF)1 and 2 are transcription factors that regulate the homeostatic response to low oxygen conditions. Since data related to the importance of HIF1 and 2 in hematopoietic stem and pr...

    Authors: Albertus T. J. Wierenga, Alan Cunningham, Ayşegül Erdem, Nuria Vilaplana Lopera, Annet Z. Brouwers-Vos, Maurien Pruis, André B. Mulder, Ulrich L. Günther, Joost H. A. Martens, Edo Vellenga and Jan Jacob Schuringa
    Citation: Cancer & Metabolism 2019 7:11
  31. Obesity confers an increased risk and accelerates the progression of multiple tumor types in rodents and humans, including both breast and colon cancer. Because sustained weight loss is rarely achieved, therap...

    Authors: Ali R. Nasiri, Marcos R. Rodrigues, Zongyu Li, Brooks P. Leitner and Rachel J. Perry
    Citation: Cancer & Metabolism 2019 7:10
  32. Metabolic reprogramming is a key feature of malignant cells. While glucose is one of the primary substrates for malignant cells, cancer cells also display a remarkable metabolic flexibility. Depending on nutri...

    Authors: Emily D. Montal, Kavita Bhalla, Ruby E. Dewi, Christian F. Ruiz, John A. Haley, Ashley E. Ropell, Chris Gordon, John D. Haley and Geoffrey D. Girnun
    Citation: Cancer & Metabolism 2019 7:8
  33. Mitochondrial oxidative phosphorylation (OXPHOS) via the respiratory chain is required for the maintenance of tumour cell proliferation and regulation of epithelial to mesenchymal transition (EMT)-related phen...

    Authors: Luke W. Thomas, Cinzia Esposito, Jenna M. Stephen, Ana S. H. Costa, Christian Frezza, Thomas S. Blacker, Gyorgy Szabadkai and Margaret Ashcroft
    Citation: Cancer & Metabolism 2019 7:7
  34. Epithelial to mesenchymal transition (EMT) is a well-characterized process of cell plasticity that may involve metabolic rewiring. In cancer, EMT is associated with malignant progression, tumor heterogeneity, ...

    Authors: Gro V. Røsland, Sissel E. Dyrstad, Deusdedit Tusubira, Reham Helwa, Tuan Zea Tan, Maria L. Lotsberg, Ina K. N. Pettersen, Anna Berg, Charlotte Kindt, Fredrik Hoel, Kirstine Jacobsen, Ari J. Arason, Agnete S. T. Engelsen, Henrik J. Ditzel, Per E. Lønning, Camilla Krakstad…
    Citation: Cancer & Metabolism 2019 7:6
  35. Mutations in isocitrate dehydrogenase 1 (IDH1) occur in various types of cancer and induce metabolic alterations resulting from the neomorphic activity that causes production of D-2-hydroxyglutarate (D-2-HG) at t...

    Authors: Tom H. Peeters, Krissie Lenting, Vincent Breukels, Sanne A. M. van Lith, Corina N. A. M. van den Heuvel, Remco Molenaar, Arno van Rooij, Ron Wevers, Paul N. Span, Arend Heerschap and William P. J. Leenders
    Citation: Cancer & Metabolism 2019 7:4
  36. Breast cancer (BC) is the most common female cancer and the leading cause of cancer death in women worldwide. Alterations in epithelial cadherin (E-cadherin) expression and functions are associated to BC, but ...

    Authors: Marina Rosso, Lara Lapyckyj, María José Besso, Marta Monge, Jaume Reventós, Francesc Canals, Jorge Oswaldo Quevedo Cuenca, María Laura Matos and Mónica Hebe Vazquez-Levin
    Citation: Cancer & Metabolism 2019 7:5
  37. Serum and urine metabolites have been investigated for their use as cancer biomarkers. The specificity of candidate metabolites can be limited by the impact of other disorders on metabolite levels. In particul...

    Authors: Matthias Pietzke, Salvador Fernandez Arroyo, David Sumpton, Gillian M. Mackay, Begoña Martin-Castillo, Jordi Camps, Jorge Joven, Javier A. Menendez and Alexei Vazquez
    Citation: Cancer & Metabolism 2019 7:3
  38. Tumour cells rely on glycolysis and mitochondrial oxidative phosphorylation (OXPHOS) to survive. Thus, mitochondrial OXPHOS has become an increasingly attractive area for therapeutic exploitation in cancer. Ho...

    Authors: Luke W. Thomas, Jenna M. Stephen, Cinzia Esposito, Simon Hoer, Robin Antrobus, Afshan Ahmed, Hasan Al-Habib and Margaret Ashcroft
    Citation: Cancer & Metabolism 2019 7:2
  39. The role of tumor protein D54 in breast cancer has not been studied and its function in breast cancer remains unclear. In our previous pharmacogenomic studies using lymphoblastoid cell line (LCL), this protein...

    Authors: Yongxian Zhuang, Reynold C. Ly, Carleigh V. Frazier, Jia Yu, Sisi Qin, Xiao-Yang Fan, Matthew P. Goetz, Judy C. Boughey, Richard Weinshilboum and Liewei Wang
    Citation: Cancer & Metabolism 2019 7:1
  40. Recent in vitro and in vivo work has shown that lactate provides an important source of carbon for metabolic reactions in cancer cell mitochondria. An interesting question is whether lactate is oxidized by lactat...

    Authors: Xiangfeng Niu, Ying-Jr Chen, Peter A. Crawford and Gary J. Patti
    Citation: Cancer & Metabolism 2018 6:19
  41. In response to oncogenic stress, the tumour suppressor protein p53 can induce the elimination of cells through induction of cell death or senescence, helping to restrain malignant progression. Conversely, unde...

    Authors: Timothy J. Humpton, Andreas K. Hock, Oliver D. K. Maddocks and Karen H. Vousden
    Citation: Cancer & Metabolism 2018 6:18
  42. While self-reported exercise is associated with a reduction in the risk of recurrence in colorectal cancer, the molecular mechanisms underpinning this relationship are unknown. Furthermore, the effect of exerc...

    Authors: Min Lu, Sydney M Sanderson, Amelia Zessin, Kathleen A Ashcraft, Lee W Jones, Mark W Dewhirst, Jason W Locasale and David S Hsu
    Citation: Cancer & Metabolism 2018 6:14
  43. It is becoming increasingly recognized that weight and nutritional status can impact cancer survival. We have previously shown that obese mice with syngeneic acute lymphoblastic leukemia (ALL) have poorer resp...

    Authors: Jonathan Tucci, Waseem Alhushki, Ting Chen, Xia Sheng, Yong-Mi Kim and Steven D. Mittelman
    Citation: Cancer & Metabolism 2018 6:15
  44. PCSK9 regulates low-density lipoprotein cholesterol (LDLc) level and has been implicated in hypercholesterolemia. Aberrant plasma lipid profile is often associated with various cancers. Clinically, the relatio...

    Authors: Dipti Athavale, Surbhi Chouhan, Vimal Pandey, Shyamananda Singh Mayengbam, Snahlata Singh and Manoj Kumar Bhat
    Citation: Cancer & Metabolism 2018 6:16
  45. While most cancer cells preferentially express the M2 isoform of the glycolytic enzyme pyruvate kinase (PKM2), PKM2 is dispensable for tumor development in several mouse cancer models. PKM2 is expressed in hum...

    Authors: Alissandra L Hillis, Allison N Lau, Camille X Devoe, Talya L Dayton, Laura V Danai, Dolores Di Vizio and Matthew G Vander Heiden
    Citation: Cancer & Metabolism 2018 6:17

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