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Review
Virtually everyone working in cancer research is familiar with the “Warburg effect”, i.e., anaerobic glycolysis in the presence of oxygen in tumor cells. However, few people nowadays are aware of what lead Ott...
Cancer & Metabolism 2016 4:5
Published on: 8 March 2016
Review
Genome scale data on biological systems has increasingly become available by sequencing of DNA and RNA, and by mass spectrometric quantification of proteins and metabolites. The cellular components from which ...
Cancer & Metabolism 2016 4:4
Published on: 19 February 2016
Research
Hypoxia and inflammation have been identified as hallmarks of cancer. A majority of hepatocellular carcinomas are preceded by hepatitis B- or C-related chronic infections suggesting that liver cancer developme...
Cancer & Metabolism 2016 4:3
Published on: 17 February 2016
Meeting report
Major contributions of the 2nd annual meeting of the International Society of Cancer Metabolism, held in Venice, September 16–19, 2015, are here described and discussed. Among these, the impact of cancer metab...
Cancer & Metabolism 2016 4(Suppl 1):1
Published on: 15 February 2016
This article is part of a Supplement: Volume 4 Supplement 1
Review
Metabolism is essential for life, and its alteration is implicated in multiple human diseases. The transformation from a normal to a cancerous cell requires metabolic changes to fuel the high metabolic demands...
Cancer & Metabolism 2015 3:14
Published on: 22 December 2015
Research
Two-hydroxyglutarate (2HG) is present at low concentrations in healthy mammalian cells as both an L and D enantiomer. Both the L and D enantiomers have been implicated in regulating cellular physiology by mech...
Cancer & Metabolism 2015 3:13
Published on: 1 December 2015
Research
Numerous studies have demonstrated that functional mitochondria are required for tumorigenesis, suggesting that mitochondrial oxidative phosphorylation (OXPHOS) might be a potential target for cancer therapy. ...
Cancer & Metabolism 2015 3:11
Published on: 20 October 2015
Research
Pancreatic ductal adenocarcinomas (PDA) activate a glutamine-dependent pathway of cytosolic nicotinamide adenine dinucleotide phosphate (NADPH) production to maintain redox homeostasis and support proliferatio...
Cancer & Metabolism 2015 3:12
Published on: 12 October 2015
Research
Glucose metabolism links metabolic status to protein acetylation. However, it remains poorly understood to what extent do features of glucose metabolism contribute to protein acetylation and whether the proces...
Cancer & Metabolism 2015 3:10
Published on: 23 September 2015
Review
In recent years, advances in metabolic imaging have become dependable tools for the diagnosis and treatment assessment in cancer. Dynamic nuclear polarization (DNP) has recently emerged as a promising technolo...
Cancer & Metabolism 2015 3:9
Published on: 14 September 2015
Research
Mitochondria are more than just the powerhouse of cells; they dictate if a cell dies or survives. Mitochondria are dynamic organelles that constantly undergo fusion and fission in response to environmental con...
Cancer & Metabolism 2015 3:8
Published on: 26 August 2015
Research
Pyruvate dehydrogenase (PDH) occupies a central node of intermediary metabolism, converting pyruvate to acetyl-CoA, thus committing carbon derived from glucose to an aerobic fate rather than an anaerobic one. ...
Cancer & Metabolism 2015 3:7
Published on: 29 June 2015
Research
Systematic quantitative methodologies are needed to understand the heterogeneity of cell metabolism across cell types in normal physiology, disease, and treatment. Metabolic flux analysis (MFA) can be used to ...
Cancer & Metabolism 2015 3:6
Published on: 28 May 2015
Research
The gene encoding the serine biosynthesis pathway enzyme PHGDH is located in a region of focal genomic copy number gain in human cancers. Cells with PHGDH amplification are dependent on enzyme expression for prol...
Cancer & Metabolism 2015 3:5
Published on: 29 April 2015
Review
Mitophagy is a selective form of macro-autophagy in which mitochondria are selectively targeted for degradation in autophagolysosomes. Mitophagy can have the beneficial effect of eliminating old and/or damaged...
Cancer & Metabolism 2015 3:4
Published on: 26 March 2015
Case report
Based on the hypothesis that cancer cells may not be able to metabolize ketones as efficiently as normal brain cells, the ketogenic diet (KD) has been proposed as a complementary or alternative therapy for tre...
Cancer & Metabolism 2015 3:3
Published on: 25 March 2015
Research
Hypoxic niches in solid tumors harbor therapy-resistant cells. Hypoxia-activated prodrugs (HAPs) have been designed to overcome this resistance and, to date, have begun to show clinical efficacy. However, clin...
Cancer & Metabolism 2015 3:2
Published on: 29 January 2015
Review
Unchecked growth and proliferation is a hallmark of cancer, and numerous oncogenic mutations reprogram cellular metabolism to fuel these processes. As a central metabolic organelle, mitochondria execute critic...
Cancer & Metabolism 2015 3:1
Published on: 25 January 2015
Erratum
No abstract
Cancer & Metabolism 2014 2:127
Published on: 23 December 2014
The original article was published in Cancer & Metabolism 2014 2:25
Research
Succinate dehydrogenase (SDH) is a mitochondrial metabolic enzyme complex involved in both the electron transport chain and the citric acid cycle. SDH mutations resulting in enzymatic dysfunction have been fou...
Cancer & Metabolism 2014 2:21
Published on: 15 December 2014
Research
Cell growth requires fatty acids for membrane synthesis. Fatty acids are assembled from 2-carbon units in the form of acetyl-CoA (AcCoA). In nutrient and oxygen replete conditions, acetyl-CoA is predominantly ...
Cancer & Metabolism 2014 2:23
Published on: 11 December 2014
Commentary
No abstract
Cancer & Metabolism 2014 2:27
Published on: 11 December 2014
Review
Mitochondria produce reactive oxygen species (mROS) as a natural by-product of electron transport chain activity. While initial studies focused on the damaging effects of reactive oxygen species, a recent para...
Cancer & Metabolism 2014 2:17
Published on: 28 November 2014
Meeting report
Here, we present a report of the 2014 annual Beatson International Cancer Conference, Glasgow, July 6–9, 2014. The theme was “Powering the Cancer Machine”, focusing on oncogenic signals that regulate metabolic re...
Cancer & Metabolism 2014 2:25
Published on: 28 November 2014
The Erratum to this article has been published in Cancer & Metabolism 2014 2:127
Erratum
Cancer & Metabolism 2014 2:24
Published on: 4 November 2014
The original article was published in Cancer & Metabolism 2014 2:13
