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  1. Content type: Research

    Gleason scores (GS) 3+3 and 3+4 prostate cancers (PCa) differ greatly in their clinical courses, with Gleason pattern (GP) 4 representing a major independent risk factor for cancer progression. However, Gleaso...

    Authors: Ilinca Georgescu, Robert J. Gooding, R. Christopher Doiron, Andrew Day, Shamini Selvarajah, Chris Davidson, David M. Berman and Paul C. Park

    Citation: Cancer & Metabolism 2016 4:8

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  2. Content type: Research

    The majority of cancer cells have a unique metabolic requirement for methionine that is not observed in normal, non-tumorigenic cells. This phenotype is described as “methionine dependence” or “methionine stre...

    Authors: Stacey L. Borrego, Johannes Fahrmann, Rupsa Datta, Chiara Stringari, Dmitry Grapov, Michael Zeller, Yumay Chen, Ping Wang, Pierre Baldi, Enrico Gratton, Oliver Fiehn and Peter Kaiser

    Citation: Cancer & Metabolism 2016 4:9

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  3. Content type: Methodology

    Metabolism gained increasing interest for the understanding of diseases and to pinpoint therapeutic intervention points. However, classical metabolomics techniques only provide a very static view on metabolism...

    Authors: Daniel Weindl, Thekla Cordes, Nadia Battello, Sean C. Sapcariu, Xiangyi Dong, Andre Wegner and Karsten Hiller

    Citation: Cancer & Metabolism 2016 4:10

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  4. Content type: Research

    The effect of moderately elevated blood glucose levels among non-diabetic subjects on cancer prognosis is not well described. The goal of this study was to examine the association of elevated random blood gluc...

    Authors: Behjatolah Monzavi-Karbassi, Rhonda Gentry, Varinder Kaur, Eric R. Siegel, Fariba Jousheghany, Srikanth Medarametla, Barbara J. Fuhrman, A. Mazin Safar, Laura F. Hutchins and Thomas Kieber-Emmons

    Citation: Cancer & Metabolism 2016 4:7

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  5. Content type: Research

    Enhanced macromolecule biosynthesis is integral to growth and proliferation of cancer cells. Lipid biosynthesis has been predicted to be an essential process in cancer cells. However, it is unclear which enzym...

    Authors: Barrie Peck, Zachary T. Schug, Qifeng Zhang, Beatrice Dankworth, Dylan T. Jones, Elizabeth Smethurst, Rachana Patel, Susan Mason, Ming Jiang, Rebecca Saunders, Michael Howell, Richard Mitter, Bradley Spencer-Dene, Gordon Stamp, Lynn McGarry, Daniel James…

    Citation: Cancer & Metabolism 2016 4:6

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  6. Content type: Review

    Genome scale data on biological systems has increasingly become available by sequencing of DNA and RNA, and by mass spectrometric quantification of proteins and metabolites. The cellular components from which ...

    Authors: Joerg Martin Buescher and Edward M Driggers

    Citation: Cancer & Metabolism 2016 4:4

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  7. Content type: Research

    Hypoxia and inflammation have been identified as hallmarks of cancer. A majority of hepatocellular carcinomas are preceded by hepatitis B- or C-related chronic infections suggesting that liver cancer developme...

    Authors: Nadia Battello, Andreas David Zimmer, Carole Goebel, Xiangyi Dong, Iris Behrmann, Claude Haan, Karsten Hiller and Andre Wegner

    Citation: Cancer & Metabolism 2016 4:3

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  8. Content type: Meeting report

    Major contributions of the 2nd annual meeting of the International Society of Cancer Metabolism, held in Venice, September 16–19, 2015, are here described and discussed. Among these, the impact of cancer metab...

    Authors: Nicola Baldini, Pierre Sonveaux, Angelo De Milito, Claudiu T. Supuran, Angela M. Otto, Christian M. Stock, Stine F. Pedersen, Rosy Favicchio and Sofia Avnet

    Citation: Cancer & Metabolism 2016 4(Suppl 1):1

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    This article is part of a Supplement: Volume 4 Supplement 1

  9. Content type: Review

    Metabolism is essential for life, and its alteration is implicated in multiple human diseases. The transformation from a normal to a cancerous cell requires metabolic changes to fuel the high metabolic demands...

    Authors: Elke Katrin Markert and Alexei Vazquez

    Citation: Cancer & Metabolism 2015 3:14

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  10. Content type: Research

    Two-hydroxyglutarate (2HG) is present at low concentrations in healthy mammalian cells as both an L and D enantiomer. Both the L and D enantiomers have been implicated in regulating cellular physiology by mech...

    Authors: Susan J. Gelman, Nathaniel G. Mahieu, Kevin Cho, Elizabeth M. Llufrio, Timothy A. Wencewicz and Gary J. Patti

    Citation: Cancer & Metabolism 2015 3:13

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  11. Content type: Research

    Numerous studies have demonstrated that functional mitochondria are required for tumorigenesis, suggesting that mitochondrial oxidative phosphorylation (OXPHOS) might be a potential target for cancer therapy. ...

    Authors: Laura Schöckel, Andrea Glasauer, Farhan Basit, Katharina Bitschar, Hoa Truong, Gerrit Erdmann, Carolyn Algire, Andrea Hägebarth, Peter HGM Willems, Charlotte Kopitz, Werner JH Koopman and Mélanie Héroult

    Citation: Cancer & Metabolism 2015 3:11

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  12. Content type: Research

    Pancreatic ductal adenocarcinomas (PDA) activate a glutamine-dependent pathway of cytosolic nicotinamide adenine dinucleotide phosphate (NADPH) production to maintain redox homeostasis and support proliferatio...

    Authors: Gaurab Chakrabarti, Zachary R. Moore, Xiuquan Luo, Mariya Ilcheva, Aktar Ali, Mahesh Padanad, Yunyun Zhou, Yang Xie, Sandeep Burma, Pier P. Scaglioni, Lewis C. Cantley, Ralph J. DeBerardinis, Alec C. Kimmelman, Costas A. Lyssiotis and David A. Boothman

    Citation: Cancer & Metabolism 2015 3:12

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  13. Content type: Research

    Glucose metabolism links metabolic status to protein acetylation. However, it remains poorly understood to what extent do features of glucose metabolism contribute to protein acetylation and whether the proces...

    Authors: Ahmad A. Cluntun, He Huang, Lunzhi Dai, Xiaojing Liu, Yingming Zhao and Jason W. Locasale

    Citation: Cancer & Metabolism 2015 3:10

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  14. Content type: Review

    In recent years, advances in metabolic imaging have become dependable tools for the diagnosis and treatment assessment in cancer. Dynamic nuclear polarization (DNP) has recently emerged as a promising technolo...

    Authors: Lucia Salamanca-Cardona and Kayvan R. Keshari

    Citation: Cancer & Metabolism 2015 3:9

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  15. Content type: Research

    Mitochondria are more than just the powerhouse of cells; they dictate if a cell dies or survives. Mitochondria are dynamic organelles that constantly undergo fusion and fission in response to environmental con...

    Authors: M. Christiane Brahimi-Horn, Sandy Giuliano, Estelle Saland, Sandra Lacas-Gervais, Tatiana Sheiko, Joffrey Pelletier, Isabelle Bourget, Frédéric Bost, Chloé Féral, Etienne Boulter, Michel Tauc, Mircea Ivan, Barbara Garmy-Susini, Alexandra Popa, Bernard Mari, Jean-Emmanuel Sarry…

    Citation: Cancer & Metabolism 2015 3:8

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  16. Content type: Research

    Pyruvate dehydrogenase (PDH) occupies a central node of intermediary metabolism, converting pyruvate to acetyl-CoA, thus committing carbon derived from glucose to an aerobic fate rather than an anaerobic one. ...

    Authors: Kartik N. Rajagopalan, Robert A. Egnatchik, Maria A. Calvaruso, Ajla T. Wasti, Mahesh S. Padanad, Lindsey K. Boroughs, Bookyung Ko, Christopher T. Hensley, Melih Acar, Zeping Hu, Lei Jiang, Juan M. Pascual, Pier Paolo Scaglioni and Ralph J. DeBerardinis

    Citation: Cancer & Metabolism 2015 3:7

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  17. Content type: Research

    Systematic quantitative methodologies are needed to understand the heterogeneity of cell metabolism across cell types in normal physiology, disease, and treatment. Metabolic flux analysis (MFA) can be used to ...

    Authors: Philip M Tedeschi, Nadine Johnson-Farley, Hongxia Lin, Laura M Shelton, Takushi Ooga, Gillian Mackay, Niels Van Den Broek, Joseph R Bertino and Alexei Vazquez

    Citation: Cancer & Metabolism 2015 3:6

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  18. Content type: Research

    The gene encoding the serine biosynthesis pathway enzyme PHGDH is located in a region of focal genomic copy number gain in human cancers. Cells with PHGDH amplification are dependent on enzyme expression for prol...

    Authors: Katherine R Mattaini, Edward J Brignole, Mitali Kini, Shawn M Davidson, Brian P Fiske, Catherine L Drennan and Matthew G Vander Heiden

    Citation: Cancer & Metabolism 2015 3:5

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  19. Content type: Review

    Mitophagy is a selective form of macro-autophagy in which mitochondria are selectively targeted for degradation in autophagolysosomes. Mitophagy can have the beneficial effect of eliminating old and/or damaged...

    Authors: Aparajita H Chourasia, Michelle L Boland and Kay F Macleod

    Citation: Cancer & Metabolism 2015 3:4

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  20. Content type: Case report

    Based on the hypothesis that cancer cells may not be able to metabolize ketones as efficiently as normal brain cells, the ketogenic diet (KD) has been proposed as a complementary or alternative therapy for tre...

    Authors: Kenneth Schwartz, Howard T Chang, Michele Nikolai, Joseph Pernicone, Sherman Rhee, Karl Olson, Peter C Kurniali, Norman G Hord and Mary Noel

    Citation: Cancer & Metabolism 2015 3:3

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  21. Content type: Research

    Hypoxic niches in solid tumors harbor therapy-resistant cells. Hypoxia-activated prodrugs (HAPs) have been designed to overcome this resistance and, to date, have begun to show clinical efficacy. However, clin...

    Authors: Jonathan W Wojtkowiak, Heather C Cornnell, Shingo Matsumoto, Keita Saito, Yoichi Takakusagi, Prasanta Dutta, Munju Kim, Xiaomeng Zhang, Rafael Leos, Kate M Bailey, Gary Martinez, Mark C Lloyd, Craig Weber, James B Mitchell, Ronald M Lynch, Amanda F Baker…

    Citation: Cancer & Metabolism 2015 3:2

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  22. Content type: Research

    Succinate dehydrogenase (SDH) is a mitochondrial metabolic enzyme complex involved in both the electron transport chain and the citric acid cycle. SDH mutations resulting in enzymatic dysfunction have been fou...

    Authors: Paul-Joseph P Aspuria, Sophia Y Lunt, Leif Väremo, Laurent Vergnes, Maricel Gozo, Jessica A Beach, Brenda Salumbides, Karen Reue, W Ruprecht Wiedemeyer, Jens Nielsen, Beth Y Karlan and Sandra Orsulic

    Citation: Cancer & Metabolism 2014 2:21

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  23. Content type: Research

    Cell growth requires fatty acids for membrane synthesis. Fatty acids are assembled from 2-carbon units in the form of acetyl-CoA (AcCoA). In nutrient and oxygen replete conditions, acetyl-CoA is predominantly ...

    Authors: Jurre J Kamphorst, Michelle K Chung, Jing Fan and Joshua D Rabinowitz

    Citation: Cancer & Metabolism 2014 2:23

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  24. Content type: Meeting report

    Here, we present a report of the 2014 annual Beatson International Cancer Conference, Glasgow, July 6–9, 2014. The theme was “Powering the Cancer Machine”, focusing on oncogenic signals that regulate metabolic re...

    Authors: Jurre J Kamphorst and Daniel J Murphy

    Citation: Cancer & Metabolism 2014 2:25

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    The Erratum to this article has been published in Cancer & Metabolism 2014 2:127

  25. Content type: Review

    Mitochondria produce reactive oxygen species (mROS) as a natural by-product of electron transport chain activity. While initial studies focused on the damaging effects of reactive oxygen species, a recent para...

    Authors: Lucas B Sullivan and Navdeep S Chandel

    Citation: Cancer & Metabolism 2014 2:17

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  26. Content type: Erratum

    Authors: Debarshi Roy, Susmita Mondal, Chen Wang, Xiaoping He, Ashwani Khurana, Shailendra Giri, Robert Hoffmann, Deok-Beom Jung, Sung H Kim, Eduardo N Chini, Juliana Camacho Periera, Clifford D Folmes, Andrea Mariani, Sean C Dowdy, Jamie N Bakkum-Gamez, Shaun M Riska…

    Citation: Cancer & Metabolism 2014 2:24

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    The original article was published in Cancer & Metabolism 2014 2:13

  27. Content type: Research

    Accumulating preclinical and clinical evidence implicates epithelial-mesenchymal transition (EMT) in acquired resistance to anticancer drugs; however, mechanisms by which the mesenchymal state determines drug ...

    Authors: Yuting Sun, Anneleen Daemen, Georgia Hatzivassiliou, David Arnott, Catherine Wilson, Guanglei Zhuang, Min Gao, Peter Liu, Aaron Boudreau, Leisa Johnson and Jeff Settleman

    Citation: Cancer & Metabolism 2014 2:20

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  28. Content type: Review

    It is a well-established scientific observation that mammalian cells contain fidelity proteins that appear to protect against and adapt to various forms of endogenous and exogenous cellular conditions. Loss of...

    Authors: Yueming Zhu, Yufan Yan, Daniel R Principe, Xianghui Zou, Athanassios Vassilopoulos and David Gius

    Citation: Cancer & Metabolism 2014 2:15

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  29. Content type: Review

    In order to solve a jigsaw puzzle, one must first have the complete picture to logically connect the pieces. However, in cancer biology, we are still gaining an understanding of all the signaling pathways that...

    Authors: Rana Elkholi, Thibaud T Renault, Madhavika N Serasinghe and Jerry E Chipuk

    Citation: Cancer & Metabolism 2014 2:16

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  30. Content type: Opinion

    Macroautophagy (autophagy hereafter) captures and degrades intracellular proteins and organelles in lysosomes as a quality control mechanism and recycles their components to sustain survival in starvation. Cel...

    Authors: Eileen White

    Citation: Cancer & Metabolism 2014 2:14

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  31. Content type: Research

    Aberrant energy metabolism is a hallmark of cancer. To fulfill the increased energy requirements, tumor cells secrete cytokines/factors inducing muscle and fat degradation in cancer patients, a condition known...

    Authors: Surendra K Shukla, Teklab Gebregiworgis, Vinee Purohit, Nina V Chaika, Venugopal Gunda, Prakash Radhakrishnan, Kamiya Mehla, Iraklis I Pipinos, Robert Powers, Fang Yu and Pankaj K Singh

    Citation: Cancer & Metabolism 2014 2:18

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    The Erratum to this article has been published in Cancer & Metabolism 2014 2:23

  32. Content type: Research

    Metformin is widely used in the treatment of diabetes, and there is interest in ‘repurposing’ the drug for cancer prevention or treatment. However, the mechanism underlying the metabolic effects of metformin r...

    Authors: Sylvia Andrzejewski, Simon-Pierre Gravel, Michael Pollak and Julie St-Pierre

    Citation: Cancer & Metabolism 2014 2:12

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  33. Content type: Research

    Loss of the endosulfatase HSulf-1 is common in ovarian cancer, upregulates heparin binding growth factor signaling and potentiates tumorigenesis and angiogenesis. However, metabolic differences between isogeni...

    Authors: Debarshi Roy, Susmita Mondal, Chen Wang, Xiaoping He, Ashwani Khurana, Shailendra Giri, Robert Hoffmann, Deok-Beom Jung, Sung H Kim, Eduardo N Chini, Juliana Camacho Periera, Clifford D Folmes, Andrea Mariani, Sean C Dowdy, Jamie N Bakkum-Gamez, Shaun M Riska…

    Citation: Cancer & Metabolism 2014 2:13

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    The Erratum to this article has been published in Cancer & Metabolism 2014 2:24

  34. Content type: Research

    Alterations in glucose metabolism and epithelial-mesenchymal transition (EMT) constitute two important characteristics of carcinoma progression toward invasive cancer. Despite an extensive characterization of ...

    Authors: Mark Masin, Jessica Vazquez, Simona Rossi, Svenja Groeneveld, Natasha Samson, Petra C Schwalie, Bart Deplancke, Laura E Frawley, Jérôme Gouttenoire, Darius Moradpour, Trudy G Oliver and Etienne Meylan

    Citation: Cancer & Metabolism 2014 2:11

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  35. Content type: Review

    Cancer is a heterogeneous set of diseases characterized by different molecular and cellular features. Over the past decades, researchers have attempted to grasp the complexity of cancer by mapping the genetic ...

    Authors: Edoardo Gaude and Christian Frezza

    Citation: Cancer & Metabolism 2014 2:10

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  36. Content type: Methodology

    Cellular metabolism is highly dynamic and continuously adjusts to the physiological program of the cell. The regulation of metabolism appears at all biological levels: (post-) transcriptional, (post-) translat...

    Authors: Matthias Pietzke, Christin Zasada, Susann Mudrich and Stefan Kempa

    Citation: Cancer & Metabolism 2014 2:9

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  37. Content type: Research

    Cancer cells, and a variety of normal cells, exhibit aerobic glycolysis, high rates of glucose fermentation in the presence of normal oxygen concentrations, also known as the Warburg effect. This metabolism is...

    Authors: Tamir Epstein, Liping Xu, Robert J Gillies and Robert A Gatenby

    Citation: Cancer & Metabolism 2014 2:7

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