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Table 1 Cell survival of irradiated cells. Surviving fractions are presented as percentage surviving colonies (± standard deviation), normalized to the non-irradiated control per EGCG treatment condition. Colonies > 50 cells were considered to be derived from cells that survived radiotherapy. Surviving fractions were normalized to plating efficiency. The surviving fractions are also visualized in Fig. 5a

From: Isocitrate dehydrogenase 1-mutated cancers are sensitive to the green tea polyphenol epigallocatechin-3-gallate

  EGCG (μM)
IR (Gy) 0 20 50 100
HCT116
 0 100 (± 0) 100 (± 0) 100 (± 0) 100 (± 0)
 2 74 (± 12) 62 (± 3) 48 (± 11) 50 (± 3)
 4 44 (± 9) 37 (± 6) 19 (± 1) 16 (± 2)
HCT116-IDH1wt/R132H
 0 100 (± 0) 100 (± 0) 100 (± 0) 100 (± 0)
 2 33 (± 8) 50 (± 3) 39 (± 6) 16 (± 0.5)
 4 24 (± 5) 28 (± 7) 5 (± 0.5) 5 (± 0.5)
HCT116-IDH1wt/R132H + AGI-5198
 0 100 (± 0) 100 (± 0) 100 (± 0) 100 (± 0)
 2 44 (± 11) 46 (± 9) 55 (± 3) 57 (± 17)
 4 13 (± 4) 18 (± 2) 21 (± 2) 22 (± 6)