Table 1 Cell survival of irradiated cells. Surviving fractions are presented as percentage surviving colonies (± standard deviation), normalized to the non-irradiated control per EGCG treatment condition. Colonies > 50 cells were considered to be derived from cells that survived radiotherapy. Surviving fractions were normalized to plating efficiency. The surviving fractions are also visualized in Fig. 5a
|  | EGCG (μM) | |||
|---|---|---|---|---|
IR (Gy) | 0 | 20 | 50 | 100 |
HCT116 | ||||
 0 | 100 (± 0) | 100 (± 0) | 100 (± 0) | 100 (± 0) |
 2 | 74 (± 12) | 62 (± 3) | 48 (± 11) | 50 (± 3) |
 4 | 44 (± 9) | 37 (± 6) | 19 (± 1) | 16 (± 2) |
HCT116-IDH1wt/R132H | ||||
 0 | 100 (± 0) | 100 (± 0) | 100 (± 0) | 100 (± 0) |
 2 | 33 (± 8) | 50 (± 3) | 39 (± 6) | 16 (± 0.5) |
 4 | 24 (± 5) | 28 (± 7) | 5 (± 0.5) | 5 (± 0.5) |
HCT116-IDH1wt/R132H + AGI-5198 | ||||
 0 | 100 (± 0) | 100 (± 0) | 100 (± 0) | 100 (± 0) |
 2 | 44 (± 11) | 46 (± 9) | 55 (± 3) | 57 (± 17) |
 4 | 13 (± 4) | 18 (± 2) | 21 (± 2) | 22 (± 6) |