Fig. 1

The hallmarks of cancer. The core hallmarks of cancer are arranged around the circle. Given their function, the molecular hallmarks are divided into those promoting cell proliferation (white background) and those promoting tissue remodelling (grey background). Genome instability has a special location in between because it is the molecular mechanism driving the emergence of the other hallmarks and the same time the potential transition between the physiological states of proliferation and remodelling. Deregulated metabolism has also a special location in between because it is a necessary requirement for both cell proliferation and tissue remodelling, and at the same time, metabolic alterations may be the cause or drive transitions between proliferation and remodelling