Fig. 3
From: Assessment of lipolysis biomarkers in adipose tissue of patients with gastrointestinal cancer
Analysis of SAT lipolysis-associated genes in gastrointestinal cancer patients with cachexia, without cachexia, and in controls. The mRNA levels of ATGL, HSL, PPARa, and MCP1 were analyzed by quantitative real-time PCR from gastrointestinal cancer patients with cachexia (N = 9), without cachexia (N = 14), and control group (N = 15). Data were normalized against the housekeeping Actin-β gene from two biological replicates and a calibrator was used as internal control. A Data show higher expression of ATGL in cachectic patients vs controls (p = 0.033) and in non-cachectic patients vs controls (p = 0.017). B HSL expression levels were higher in the cachectic group (p = 0.020) compared to controls and in the non-cachectic group (p = 0.021) with respect to controls. C, D No difference was detected in PPARa and MCP1 expression levels. *p < 0.05. Abbreviations: adipose triglyceride lipase, ATGL; hormone-sensitive lipase, HSL; peroxisome proliferator-activated receptor alpha, PPAR-a; monocyte chemoattractant protein-1, MCP1