Fig. 4From: STEAP4 inhibits cisplatin-induced chemotherapy resistance through suppressing PI3K/AKT in hepatocellular carcinomaSTEPA4 inhibits DDP-induced chemotherapy resistance in vivo. a Soft agar growth assay for the effect of STEAP4 overexpression or knockdown in DDP-induced cell growth. b Representative tumor images of orthotopic transplantation mouse model using STEAP4 overexpression or knockdown HCC cells treated with DDP. TUNEL assay was used to analyze the apoptosis of xenograft tumor tissues. c Kaplan-Meier curves with log rank test for orthotopic transplantation mouse model. d The concentration of AST and ALT of orthotopic transplantation mouse model. Bars represent the mean ± SD of three independent experiments; *P < 0.05Back to article page