Fig. 1
From: Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition
Long-term aspirin treatment regulates cellular metabolism in CRC cells. a Experimental design for proteomic analysis of long-term aspirin-treated SW620 cells (each flask represents one independent experiment) (created with BioRender.com). b Volcano plots showing protein expression changes with long-term 2-mM or 4-mM aspirin treatment compared to control. Each point represents one protein. Thresholds for proteins of interest were p < 0.05, fold change > 1.4 or < 0.71), in both 2mM and 4mM conditions (downregulated proteins in blue and upregulated in red). c Number of genes in GO biological processes categories, of all proteins of interest in both 2mM and 4mM aspirin. d Overrepresentation analysis of proteins of interest in both 2mM and 4mM aspirin, using the KEGG pathways database