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Fig. 2 | Cancer & Metabolism

Fig. 2

From: Restoring gluconeogenesis by TEF inhibited proliferation and promoted apoptosis and immune surveillance in kidney renal clear cell carcinoma

Fig. 2

Promoting gluconeogenesis inhibited the proliferation, clone formation, and induced apoptosis in renal carcinoma cells. A The relative expression of indicated genes in tumor and adjacent tissues was tested by QPCR. N = 10. B The relative expression of indicated genes in kidney tumor and normal cell lines was tested by QPCR. N = 5. C The levels of cellular glucose (left) and lactate (right) in Caki-1 and 769-P cells. N = 3. C Colony formation assay comparing Caki-1 and 769-P transfected with PCK1 overexpression lentivirus control vector. D After transfected with PCK1 OE or control vector, the cell viability of Caki-1 and 769-P cells was tested at indicated time points by CCK8 assay. E The level of apoptosis of Caki-1 and 769-P cells transfected with PCK1 OE or control vector was analyzed by Annexin V and PI staining by flow cytometry. *P < 0.05

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Cancer & Metabolism

ISSN: 2049-3002