Fig. 4
From: Tamoxifen induces radioresistance through NRF2-mediated metabolic reprogramming in breast cancer
Antioxidant signaling is increased in TAM cells and antioxidant gene expression upregulated in patients after neoadjuvant tamoxifen. A Antioxidant capacity of WT and TAM-R cells (n = 6). B NRF2 expression of WT and TAM-R cells. C Fold change of NRF2 related genes in MCF7 cells. D Tumor gene expression of NFE2L2 in 28 patients treated with neoadjuvant tamoxifen before and after tamoxifen treatment. E Histology of NRF2 expression on tumor material before (biopsy) and after (tumor resection) tamoxifen (n = 6) or anastrozole (n = 6) treatment. F NRF2 protein expression in patients treated with neoadjuvant tamoxifen or anastrozole before and after treatment (n = 6 for both groups). Data are represented as mean + SD (A). Statistical significance was determined by Student’s t test (A, B), one sample t test (C), and paired t test (D, F). *, p < 0.05; **,p < 0.01; ***, p < 0.001; ****, p < 0.0001