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Fig. 3 | Cancer & Metabolism

Fig. 3

From: Breast cancer cells that preferentially metastasize to lung or bone are more glycolytic, synthesize serine at greater rates, and consume less ATP and NADPH than parent MDA-MB-231 cells

Fig. 3

Bi-plot of Loadings and Scores from principal component analysis of Table 1 data. Flux ratios R1–R4 (see Table 1) were determined from Model 1 by simulating 13C lactate labeling from [1,2-13C] glucose, within the constraints of measured respiration rates (RR) and fluxes. The Scores reflecting individual experiments clustered into groups that corresponded to the four cell lines, with the less malignant T47D line more distant from the other three. The Loadings are indicated by arrows and provide information on relative strength of correlations between the variables R1–R4 and RR used to simulate 13C lactate labeling

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Cancer & Metabolism

ISSN: 2049-3002