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Fig. 3 | Cancer & Metabolism

Fig. 3

From: Tadalafil increases the antitumor activity of 5-FU through inhibiting PRMT5-mediated glycolysis and cell proliferation in colorectal cancer

Fig. 3

PRMT5 inhibitors suppress cell proliferation in CRC. A and B % of cell proliferation of HCT116 cells treated with A JNJ-64619178 (JNJ; 0.2, 0.4, 0.6 µM) or B tadalafil (TAD; 10, 20, 50 µM) for 24 h was evaluated by MTT assay. Mean ± SEM of three independent experiments is shown. C Colony formation assays of HCT116 cells pretreated with JNJ-64619178 (JNJ; 0, 0.3, 0.6 µM) or tadalafil (TAD; 0, 10, 30 µM). D Statistical analysis in (C). *P < 0.05; **P < 0.01; ***P < 0.001

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Cancer & Metabolism

ISSN: 2049-3002