Table 1 Baseline characteristics of the cohort
Variable | NSCLC cases (n = 241) | Cancer-free controls (n = 234) | p-value |
|---|---|---|---|
Age | |||
 Mean (range) | 69 (49–88) | 55 (20–89) | p < 0.001 |
Sex | |||
 Male (%) | 112 (46%) | 69 (29%) | p < 0.001 |
 Female (%) | 129 (54%) | 165 (71%) |  |
Stage (AJCC 7th ed.) | |||
 I (%) | 145 (60%) | N/A | - |
 II (%) | 50 (21%) |  |  |
 III (%) | 41 (17%) |  |  |
 IV (%) | 5 (2%) |  |  |
NSCLC type | |||
 Adenocarcinoma (%) | 177 (73%) | N/A | - |
 Squamous cell carcinoma (%) | 64 (27%) |  |  |
Body mass index | |||
 Mean (range) | 27.2 (14.8–49.5) | 27.0 (16.4–49.6) | 0.7 |
Comorbidities | |||
 Diabetes (%) | 55 (23%) | 16 (7%) | < 0.001 |
 COPD (%) | 68 (28%) | 17 (7.3%) | < 0.0001 |
 Hypertension (%) | 129 (54%) | 44 (19%) | < 0.001 |
 Dyslipidemia (%) | 91 (38%) | 35 (15%) | < 0.001 |
 Cardiovascular disease (%) | 72 (30%) | 14 (6%) | < 0.001 |
Smoking history | |||
 Current smoker (%) | 65 (27%) | 15 (6%) | < 0.001 |
 Ex-smoker (%) | 156 (65%) | 51 (22%) |  |
 Never smoker (%) | 20 (8%) | 48 (21%) |  |
 Unknown (%) | 0 | 120 (51%) |  |