Fig. 2
From: Ketogenic diets slow melanoma growth in vivo regardless of tumor genetics and metabolic plasticity
The level of diet-induced ketosis does not correlate with antitumor effects. A–D Blood glucose and I–L blood beta-hydroxybutyrate (BHB) concentrations of A, I A375, B, J WM47, C, K WM3311, and D, L WM3000 melanoma-bearing mice treated with CTRL, LCT, or LCT-MCT diet at different time points throughout the dietary intervention. Individual data points ± SD; n = 10–13; p values were determined by a mixed-effects analysis or two-way ANOVA with Dunnett's multiple comparisons test; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. E–H Correlation analysis between tumor volume and glucose concentration of E A375, F WM47, G WM3311, and H WM3000 melanoma-bearing mice on the day of the last glucose measurement. Pearson correlation was used to compute Pearson r coefficients and respective p values for CTRL and KD groups combined (n = 33 for A375, n = 25 for WM47, n = 25 for WM3311, n = 36 for WM3000). M–P Correlation analysis between tumor volume and BHB concentration of M A375, N WM47, O WM3311, and P WM3000 melanoma-bearing mice on the day of the last BHB measurement. Pearson correlation was used to compute Pearson r coefficients and respective p values for CTRL, LCT and LCT-MCT groups separately (n = 9–13 for CTRL, n = 7–12 for LCT and n = 7–12 for LCT-MCT groups)