Skip to main content
Fig. 2 | Cancer & Metabolism

Fig. 2

From: Effects of hyperinsulinemia on pancreatic cancer development and the immune microenvironment revealed through single-cell transcriptomics

Fig. 2

Effects of reduced hyperinsulinemia on pancreatic cancer initiation. AB Representative whole section (top) and high-magnification (bottom) images of PK-Ins1-/-;Ins2+/+ and PK-Ins1-/-;Ins2+/- male and female pancreata stained with hematoxylin and eosin. Scale bars: 2 mm (top) and 0.1 mm (bottom). CD Quantification of percent of total pancreatic area occupied by PanINs and tumor in male (blue colors) and female (orange colors) PK-Ins1-/-;Ins2+/+ and PK-Ins1-/-;Ins2+/- mice (n = 14–22) (dark blue and dark orange dots denote mice that developed PDAC). Correlations of composite PanINs plus tumor area with fasting insulin levels EF, with fasting glucose levels GH, or with body weight IJ in male and female PK-Ins1-/-;Ins2+/+ and PK-Ins1-/-;Ins2+/- mice (n = 10-22)

Back to article page