Fig. 6From: Dynamic regulation of mitochondrial pyruvate metabolism is necessary for orthotopic pancreatic tumor growthPDHA1 supports the growth of tumor cells in media without exogenous lipids. Cell colony formation was measured in DMEM media containing either 10% complete or 10% charcoal-stripped FBS to remove non-polar compounds, in either 21% or 1% oxygen environment. Note decrease in plating efficiency in hypoxic, lipid-depleted media indicated. N = 3 biological replicates. Error bars, s.e.m. *P< 0.05, **P< 0.01, ***P< 0.0001, ****P = 0Back to article page