Fig. 5

BAM15 suppresses tumor growth in C57BL/6J mice fed a high fat diet. A Schematic illustration of the experimental design. B Tumor volumes over the treatment period and C terminal tumor mass (CTRL N=5, BAM15 N=7, and CR N=5). D BAM15 distribution in tissue and plasma at time of necropsy (N=6 for plasma, N=7 for tissues). E Body weight over the treatment period and F change in body weight from treatment start (CTRL N=5, BAM15 N=7, and CR N=5). G Food intake averaged over the treatment period (CTRL N=5, BAM15 N=7, and CR N=5). H Total fat mass (CTRL N=5, BAM15 N=7, and CR N=5). I Terminal gWAT weight (CTRL N=5, BAM15 N=7, and CR N=5). J Plasma glucose and K lactate concentrations at time of necropsy (N=4 per group). Data are shown as box (mean ± 5-95% CI) and whiskers (minimum to maximum) with exception to panels B and E which are displayed as mean ± SEM. *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001. Panels B and E were assessed by two-way repeated measures ANOVA with Tukey’s multiple comparisons. Panels C, D, F, G, H, I, J, and K were assessed by one-way ANOVA with Tukey’s multiple comparisons. Abbreviations: CTRL, control; CR, calorie restriction; gWAT, gonadal white adipose tissue; gastroc, gastrocnemius