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Fig. 4 | Cancer & Metabolism

Fig. 4

From: Inhibition of glycolysis and mitochondrial respiration promotes radiosensitisation of neuroblastoma and glioma cells

Fig. 4

The effect of combination treatment on mitochondrial respiration, glycolysis and cellular energy production. UVW/NAT cells were treated with 3 Gy X-radiation, 1 mM metformin, or 5 mM 2DG as single agents or in combination for 24 h. Oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) of live cells were then measured using a Seahorse XFe96 Analyser, the shift in cell energy phenotype following treatment is shown (a) The traces obtained (Supplementary Figure 6) were then used to calculate glycolytic rate (b), minimal and maximal respiratory capacity (c) and ATP production (d)

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Cancer & Metabolism

ISSN: 2049-3002