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Fig. 6 | Cancer & Metabolism

Fig. 6

From: Pharmacological activation of pyruvate kinase M2 reprograms glycolysis leading to TXNIP depletion and AMPK activation in breast cancer cells

Fig. 6

PKM2 activation potentiates the antitumor effects of other metabolic stressors. a, b Total protein staining using SRB assay (a) or metabolically active cells using MTT assay (b) showing the efficacy of combining DASA-58 (15 μM) with different metabolic stressors/inhibitors of glycolytic branching pathways in BCa cells. Data are presented as % survival normalized to the mock treatment and daggers (†) used to indicate statistical significance between the single and the combo treatment. c Schematic illustration representing the hypothesis of combining the PKM2 activator with other metabolic modulating drugs (red font)

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Cancer & Metabolism

ISSN: 2049-3002