Skip to main content
Fig. 2 | Cancer & Metabolism

Fig. 2

From: Intracellular arginine-dependent translation sensor reveals the dynamics of arginine starvation response and resistance in ASS1-negative cells

Fig. 2

Design and demonstration of arginine sensor. a Diagram of the main components of the arginine sensor. b ArgSen fluorescence in SKLMS1 cells measured by flow cytometry. Error bars represent standard deviation. c GFP ArgSen and GFP RanSen fluorescence in SKLMS1 cells measured by microscopy. Error bars represent standard deviation. d Arginine sensor mRNA in SKLMS1 GFP ArgSen cells. Error bars represent standard error of the mean. e GFP ArgSen fluorescence with no treatment, glutamine deprivation, ADI-PEG20 treatment, and ADI-PEG20 resistance in three cell lines. Error bars represent standard deviation. f GFP ArgSen fluorescence with ADI-PEG20 treatment for 12 h, followed by normal media or continuation of treatment, in three cell lines. Error bars represent standard deviation

Back to article page

Cancer & Metabolism

ISSN: 2049-3002