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Table 2 Patient- and tumor characteristics in relation to post-treatment tissue cholesterol

From: The effect of statin treatment on intratumoral cholesterol levels and LDL receptor expression: a window-of-opportunity breast cancer trial

 

Cholesterol-low

Cholesterol-rich

P value

 

n = 28

n = 14

Age years (median)

63.0

67.5

0.97

Tumor size mm (median)

22.5

20.5

0.47

Tumor grade (NHG)

  

0.26

 1

7

2

 

 2

12

5

 

 3

9

7

 

Mitotic index

  

0.10

 1

17

5

 

 2

4

1

 

 3

7

7

 

ER (n = 31)

  

0.31

 Positive

21

7

 

 Negative

1

2

 

PR (n = 31)

  

0.14

 Positive

19

6

 

 Negative

3

3

 

HER2 (n = 30)

  

0.97

 0

5

2

 

 1+

7

3

 

 2+

5

3

 

 3+

4

1

 

Ki67 index (n = 26)

  

0.02*

 Low

14

1

 

 High

5

6

 

HMGCR (n = 38)

  

0.87

 Negative

10

4

 

 Positive

16

8

 

Serum lipid levels, median (n = 42)

   

 LDL pre-treatment

3.76

3.21

0.20

 HDL pre-treatment

1.60

1.41

0.54

 Cholesterol pre-treatment

6.10

5.20

0.08

 Apoliporotein B pre-treatment

1.07

0.91

0.11

 Apolipoprotein A1 pre-treatment

1.65

1.72

0.84

 LDL post-treatment

1.76

1.66

0.73

 HDL post-treatment

1.58

1.51

0.56

 Cholesterol post-treatment

3.70

3.45

0.47

 Apolipoprotein B post-treatment

0.60

0.55

0.38

 Apolipoprotein A1 post-treatment

1.58

1.51

0.45

  1. NHG Nottingham histologic grade I-III (post-treatment pathological report), mitotic index according to Nottingham criteria (post-treatment pathological report), baseline tumor data (pretreatment): Ki67 high if > 20%, HMGCR positive if any cytoplasmic staining, ER (estrogen receptor), PR (progesterone receptor), HER2 (human epidermal growth factor receptor 2) P values: Mann Whitney U test, linear-by-linear association chi-square test