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Table 1 Patient and tumor characteristics

From: The effect of statin treatment on intratumoral cholesterol levels and LDL receptor expression: a window-of-opportunity breast cancer trial

 

Completed all study parts

Complete cholesterol pairs

 

n = 42

n = 14

Age years (mean, range)

63 (35-89)

68 (50-83)

Tumor size mm (mean, range)

21 (6-33)

23 (13-32)

Tumor grade (NHG)

  

 I

9 (21%)

4 (29%)

 II

17 (41%)

3 (21%)

 III

16 (38%)

7 (50%)

Mitotic index

  

 1

23 (55%)

6 (43%)

 2

5 (12%)

1 (7%)

 3

14 (33%)

7 (50%)

ER (n = 30), baseline

  

 Positive

27 (90%)

14 (100%)

 Negative

3 (10%)

0 (0%)

PR (n = 30), baseline

  

 Positive

24(80%)

11 (79%)

 Negative

6 (20%)

3 (21%)

HER2 (n = 29), baseline

  

 0

7 (24%)

4 (32%)

 1+

10 (34%)

5 (38%)

 2+

7 (24%)

2 (15%)

 3+

5 (17%)

2 (15%)

Ki67 index (n = 26), baseline

  

 Low

15 (58%)

7 (54%)

 High

11 (42%)

6 (46%)

HMGCR (n = 38)

  

 Negative

14 (37%)

5 (38%)

 Positive

24 (63%)

8 (62%)

  1. NHG Nottingham histologic grade I-III (post-treatment pathological report), mitotic index according to Nottingham criteria (post-treatment pathological report), baseline tumor data (pretreatment): Ki67 high if >20%, HMGCR positive if any cytoplasmic staining, ER (estrogen receptor), PR (progesterone receptor), HER2 (human epidermal growth factor receptor 2)
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Cancer & Metabolism

ISSN: 2049-3002