Skip to main content
Fig. 2 | Cancer & Metabolism

Fig. 2

From: The conversion of formate into purines stimulates mTORC1 leading to CAD-dependent activation of pyrimidine synthesis

Fig. 2

Phospho-proteomic analysis. a Volcano plot reporting the log-ratio of phosphopeptide quantifications in HAP1-ΔSHMT2 cells supplemented with formate (formate) relative to HAP1-ΔSHMT2 cells (Ctrl), together with the associated statistical significance. b Volcano plot reporting the log-ratio of phosphopeptide quantifications in HAP1-ΔSHMT2 cells supplemented with formate and treated with rapamycin (Rapa+For) relative to HAP1-ΔSHMT2 cells treated with rapamycin (Rapa), together with the associated statistical significance. Each symbol represents a phosphorylation site. The statistical analysis was conducted on 3 technical replicates from 1 experiment, and the significance was calculated using an unequal variance two-tailed t test. c Venn diagram highlighting the overlap and non-overlap of significant changes in the absence and under treatment with rapamycin

Back to article page

Cancer & Metabolism

ISSN: 2049-3002