Fig. 1
From: Therapy-induced lipid uptake and remodeling underpin ferroptosis hypersensitivity in prostate cancer
Therapy-induced reprograming of metabolic networks in a longitudinal PCa tumor xenograft model of CRPC progression. a Gene set variation analysis (GSVA) of ten tumors at PSA nadir (NAD) compared to ten tumors from sham-castrated mice (INT, intact) was generated based on previously published microarray analysis of LNCaP xenograft tumors resected at different time points after castration [32]. Heatmaps were generated with a hierarchical clustering algorithm using completed linkage and Euclidean distance measures and scaled by z score (red = positive z score, blue = negative z score)