Fig. 6

Schematics of glycolysis, tricarboxylic acid cycle, and pentose phosphate pathway showing changes at the translational level of enzymes involved in the different steps. Changes in MCF7 MKL1 ΔN200 with respect to MCF7 MKL1 ΔC301 control cells. Fold-change (FC) values were taken from Supplementary File S3; only FC values higher than 0.5 (FDR < 0.01) were considered. Blue, glycolysis; orange, PPP; pink, TCA. Arrow colors indicate the following: increase (blue: FC > 1.0, light blue: 1.0 > FC > 0.5); decrease (red: FC > 1.0, light red: 1.0 > FC > 0.5); gray: no significant changes; orange: variable changes within an enzyme complex. Values shown inside the small boxes indicate the fold change in the amount of each metabolite between both cell lines (Supplementary Table T6). Stars depict changes in the prevailing isoform. Steps associated with NADP reduction are indicated