Fig. 4
From: PHGDH supports liver ceramide synthesis and sustains lipid homeostasis
PHGDH knockdown does not promote deoxyshingolipid formation. a Concentration of individual deoxysphingolipids and dihydrodeoxysphingolipids in the serum of shREN and shPHGDH mice. b Total concentration of deoxysphingolipids (doxCer) and dihydrodeoxysphingolipids (dihydro-doxCer) in the serum of shREN and shPHGDH mice. c Quantity of deoxysphingolipids in the liver of shREN and shPHGDH mice. Quantities were normalized to mg of tissue. d Total quantity of deoxysphingolipids (doxCer) and dihydrodeoxysphingolipids (dihydro-doxCer) in the liver of shREN and shPHGDH mice. Quantities were normalized to mg of tissue. e Quantity of deoxysphinganine in the liver of shREN and shPHGDH mice. Quantities were normalized to mg of tissue. For a–e, 8-month-old shREN (N = 11) and shPHGDH (N = 12) mice were used for analysis