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Table 4 Yeast-human homologs with deletion suppression and OES across all tissues

From: A yeast phenomic model for the influence of Warburg metabolism on genetic buffering of doxorubicin

hGene yGene DB Fig GO term HLD L|K HLEG L|K GDSC pval gCSI pval Ref H Description hGene
ACTR2 ARP2 Both 12D Arp2/3 Protein Complex − 3.7|1.4 − 3.3|− 6.9 3.2E−02 6.0E−05 [188] 1 ARP2 actin-related protein 2 homolog
SEPT6 CDC3 Both 12D N/A − 2.1|0.7 − 2.6|0.3 1.7E−04 2.8E−05 NA 1 Septin 6
CSNK2A2 CKA2 Both 12D N/A − 5.5|1 − 4|1.2 4.3E−03 3.6E−03 NA 2 Casein kinase 2 alpha 2
DBR1 DBR1 Both 12D N/A − 2.1|0.6 − 3.5|1 4.3E−02 9.8E−04 NA 1 Debranching RNA lariats 1
PLAA DOA1 Both 12D N/A − 2.2|0.7 − 7.7|1.9 2.6E−02 1.5E−04 NA 3 Phospholipase A2 activating protein
EEF2 EFT2 Both 12D N/A − 2.7|0.2 − 2.1|1.1 1.9E−02 9.7E−06 [189] 2 Eukaryotic translation elongation factor 2
HARS HTS1 Both 12D N/A − 2.4|0.6 − 2.9|0.5 4.1E−03 1.6E−03 NA 1 Histidyl-tRNA synthetase
CDK7 KIN28 Both 12D N/A − 2.2|1.1 − 2.5|− 1.2 2.4E−02 2.6E−04 [190,191,192] 3 Cyclin-dependent kinase 7
METAP1 MAP 1 Both 12D N/A − 4.7|3.3 − 4.2|− 0.6 8.9E−03 2.3E−02 NA 1 Methionyl aminopeptidase 1
RPL13A RPL16B Both 12D N/A − 4.5|3.7 − 5.8|1.4 1.5E−03 9.5E−05 NA 2 Ribosomal protein L13a
RPL32 RPL32 Both 12D N/A − 3.9|1 − 11.3|1.1 6.9E−03 3.6E−03 [196] 2 Ribosomal protein L32
RPL34 RPL34A Both 12D N/A − 4.8|2.3 − 7.2|2.4 1.5E−02 4.4E−03 [193,194,195] 3 Ribosomal protein L34
ZFAND4 RPL40B Both 12D N/A − 4.1|1.1 − 5.7|1.1 3.7E−02 1.7E−02 NA 2 Zinc finger AN1-type containing 4
RPS6 RPS6A Both 12D N/A − 5.7|1.8 − 6|2.6 2.0E−04 2.5E−07 [197, 198] 2 Ribosomal protein S6
HSPA4 SSE1 Both 12D N/A − 6.3|3 − 13.7|4.4 1.5E−02 4.2E−07 NA 2 Heat shock protein family A (Hsp70) member 4
NCBP1 STO1 Both 12D N/A − 3|1.7 − 4.3|1.3 2.3E−03 3.5E−04 NA 2 Nuclear cap-binding protein subunit 1
ELAC2 TRZ1 Both 12D N/A − 2.3|0.6 − 2.6|0.1 1.1E−05 1.5E−08 NA 3 ElaC ribonuclease Z 2
UBE2D1 UBC4 Both 12D N/A − 4.6|2.2 − 12.3|2.6 1.0E−02 8.1E−03 [199] 1 Ubiquitin conjugating enzyme E2 D1
TPRKB CGI121 gCSI 12F EKC/KEOPS Complex − 2.2|− 0.8 − 7.7|2.1 1.3E−01 7.6E−04 NA 1 TP53RK binding protein
ELOVL6 ELO2 gCSI 12F Fatty Acid Elongase Activity − 7.7|1.4 − 13.9|4.1 5.1E−01 2.7E−02 [205] 2 ELOVL fatty acid elongase 6
ELOVL6 ELO3 gCSI 12F Fatty Acid Elongase Activity − 6.3|1.3 − 10.5|1.9 5.1E−01 2.7E−02 [205] 1 ELOVL fatty acid elongase 6
NUP155 NUP170 gCSI 12F Telomere tethering at the nuclear periphery − 3.7|0.6 − 6.5|1.3 1.0E−01 4.4E−02 [215,216,217] 1 Nucleoporin 155
SSRP1 POB3 gCSI 12F FACT Complex − 4.1|1.2 − 5.1|1.4 6.0E−02 2.2E−06 [20] 2 Structure-specific recognition protein 1
TGS1 TGS1 gCSI 12F 7-methylguanosine cap hypermethylation − 2.4|2.6 − 3.3|0.7 8.5E−02 2.0E−03 NA 2 Trimethylguanosine synthase 1
VPS53 VPS53 gCSI 12F Cellular sphingolipid homeostasis − 2.4|1.8 − 5.8|1.4 2.0E−01 2.4E−02 [201,202,203,204] 2 VPS53, GARP complex subunit
USP22 UBP8 Both 12F histone deubiquitination − 2|0.8 0.3|0.3 2.3E−02 1.2E−02 NA 1 Ubiquitin-specific peptidase 22
SMC2 SMC2 gCSI 12F meiotic chromosome condensation − 3.5|1.2 0.4|− 0.9 1.1E−01 4.3E−02 [138] 3 Structural maintenance of chromosomes 2
NCAPG YCG1 gCSI 12F meiotic chromosome condensation − 2|0.8 − 0.8|− 0.6 7.9E−01 9.2E−06 [138] 3 Non-SMC condensin I complex subunit G
NCAPD2 YCS4 gCSI 12F meiotic chromosome condensation − 2.4|0.8 − 1.7|− 0.9 2.3E−01 1.7E−03 NA 2 Non-SMC condensin I complex subunit D2
USP44 UBP8 GDSC 12F histone deubiquitination − 2|0.8 0.3|0.3 4.1E−04 6.1E−01 NA 2 Ubiquitin specific peptidase 44
KDM2B JHD1 Both 12F Histone Demethylation 0.2|− 0.2 − 2.3|1.9 4.6E−02 3.5E−02 [206,207,208] 1 Lysine demethylase 2B
AMD1 SPE2 Both 12F spermine biosynthetic process 0.2|− 0.2 − 2.8|0.5 1.7E−02 1.5E−04 [200] 1 Adenosylmethionine decarboxylase 1
SMS SPE4 gCSI 12F spermine biosynthetic process − 0.8|0.4 − 2.4|1 NA 3.9E−02 NA 1 Spermine synthase
EIF3I TIF34 gCSI 12F translation reinitiation 1.2|0 − 3.9|1.4 8.2E−01 7.1E−05 NA 2 Eukaryotic translation initiation factor 3 subunit I
STRAP TIF34 gCSI 12F translation reinitiation 1.2|0 − 3.9|1.4 6.7E−01 9.1E−03 NA 2 Serine/threonine kinase receptor-associated protein
DENR TMA22 gCSI 12F translation reinitiation − 1.1|0.6 − 6.4|1.9 4.0E−01 1.9E−02 [210,211,212,213,214] 1 Density regulated re-initiation and release factor
PHF2 JHD1 GDSC 12F Histone Demethylation 0.2|− 0.2 − 2.3|1.9 1.9E−03 6.8E−02 NA 1 PHD finger protein 2
JARID2 JHD2 GDSC 12F Histone Demethylation − 0.2|0.1 − 3.2|1 1.9E−03 2.5E−02 [209] 2 Jumonji and AT-rich interaction domain containing 2
  1. For column “DB”: “gCSI,” “GDSC,” or “Both” indicate UES in the gCSI, GDSC, or both databases. Column “Fig.” refers to specific figures. Columns “HLD L|K” and “HLEG L|K” contain the L and K interaction scores for HLD and HLEG media, respectively. “GDSC pval” and “gCSI pval” refer to the significance of differential gene expression in the respective databases. “Ref” refers to relevant literature citations. “H” refers to homology type: “1,” “2,” and “3” indicate 1:1, 1:many, and many:many, respectively