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Table 4 Yeast-human homologs with deletion suppression and OES across all tissues

From: A yeast phenomic model for the influence of Warburg metabolism on genetic buffering of doxorubicin

hGene

yGene

DB

Fig

GO term

HLD L|K

HLEG L|K

GDSC pval

gCSI pval

Ref

H

Description hGene

ACTR2

ARP2

Both

12D

Arp2/3 Protein Complex

− 3.7|1.4

− 3.3|− 6.9

3.2E−02

6.0E−05

[188]

1

ARP2 actin-related protein 2 homolog

SEPT6

CDC3

Both

12D

N/A

− 2.1|0.7

− 2.6|0.3

1.7E−04

2.8E−05

NA

1

Septin 6

CSNK2A2

CKA2

Both

12D

N/A

− 5.5|1

− 4|1.2

4.3E−03

3.6E−03

NA

2

Casein kinase 2 alpha 2

DBR1

DBR1

Both

12D

N/A

− 2.1|0.6

− 3.5|1

4.3E−02

9.8E−04

NA

1

Debranching RNA lariats 1

PLAA

DOA1

Both

12D

N/A

− 2.2|0.7

− 7.7|1.9

2.6E−02

1.5E−04

NA

3

Phospholipase A2 activating protein

EEF2

EFT2

Both

12D

N/A

− 2.7|0.2

− 2.1|1.1

1.9E−02

9.7E−06

[189]

2

Eukaryotic translation elongation factor 2

HARS

HTS1

Both

12D

N/A

− 2.4|0.6

− 2.9|0.5

4.1E−03

1.6E−03

NA

1

Histidyl-tRNA synthetase

CDK7

KIN28

Both

12D

N/A

− 2.2|1.1

− 2.5|− 1.2

2.4E−02

2.6E−04

[190,191,192]

3

Cyclin-dependent kinase 7

METAP1

MAP 1

Both

12D

N/A

− 4.7|3.3

− 4.2|− 0.6

8.9E−03

2.3E−02

NA

1

Methionyl aminopeptidase 1

RPL13A

RPL16B

Both

12D

N/A

− 4.5|3.7

− 5.8|1.4

1.5E−03

9.5E−05

NA

2

Ribosomal protein L13a

RPL32

RPL32

Both

12D

N/A

− 3.9|1

− 11.3|1.1

6.9E−03

3.6E−03

[196]

2

Ribosomal protein L32

RPL34

RPL34A

Both

12D

N/A

− 4.8|2.3

− 7.2|2.4

1.5E−02

4.4E−03

[193,194,195]

3

Ribosomal protein L34

ZFAND4

RPL40B

Both

12D

N/A

− 4.1|1.1

− 5.7|1.1

3.7E−02

1.7E−02

NA

2

Zinc finger AN1-type containing 4

RPS6

RPS6A

Both

12D

N/A

− 5.7|1.8

− 6|2.6

2.0E−04

2.5E−07

[197, 198]

2

Ribosomal protein S6

HSPA4

SSE1

Both

12D

N/A

− 6.3|3

− 13.7|4.4

1.5E−02

4.2E−07

NA

2

Heat shock protein family A (Hsp70) member 4

NCBP1

STO1

Both

12D

N/A

− 3|1.7

− 4.3|1.3

2.3E−03

3.5E−04

NA

2

Nuclear cap-binding protein subunit 1

ELAC2

TRZ1

Both

12D

N/A

− 2.3|0.6

− 2.6|0.1

1.1E−05

1.5E−08

NA

3

ElaC ribonuclease Z 2

UBE2D1

UBC4

Both

12D

N/A

− 4.6|2.2

− 12.3|2.6

1.0E−02

8.1E−03

[199]

1

Ubiquitin conjugating enzyme E2 D1

TPRKB

CGI121

gCSI

12F

EKC/KEOPS Complex

− 2.2|− 0.8

− 7.7|2.1

1.3E−01

7.6E−04

NA

1

TP53RK binding protein

ELOVL6

ELO2

gCSI

12F

Fatty Acid Elongase Activity

− 7.7|1.4

− 13.9|4.1

5.1E−01

2.7E−02

[205]

2

ELOVL fatty acid elongase 6

ELOVL6

ELO3

gCSI

12F

Fatty Acid Elongase Activity

− 6.3|1.3

− 10.5|1.9

5.1E−01

2.7E−02

[205]

1

ELOVL fatty acid elongase 6

NUP155

NUP170

gCSI

12F

Telomere tethering at the nuclear periphery

− 3.7|0.6

− 6.5|1.3

1.0E−01

4.4E−02

[215,216,217]

1

Nucleoporin 155

SSRP1

POB3

gCSI

12F

FACT Complex

− 4.1|1.2

− 5.1|1.4

6.0E−02

2.2E−06

[20]

2

Structure-specific recognition protein 1

TGS1

TGS1

gCSI

12F

7-methylguanosine cap hypermethylation

− 2.4|2.6

− 3.3|0.7

8.5E−02

2.0E−03

NA

2

Trimethylguanosine synthase 1

VPS53

VPS53

gCSI

12F

Cellular sphingolipid homeostasis

− 2.4|1.8

− 5.8|1.4

2.0E−01

2.4E−02

[201,202,203,204]

2

VPS53, GARP complex subunit

USP22

UBP8

Both

12F

histone deubiquitination

− 2|0.8

0.3|0.3

2.3E−02

1.2E−02

NA

1

Ubiquitin-specific peptidase 22

SMC2

SMC2

gCSI

12F

meiotic chromosome condensation

− 3.5|1.2

0.4|− 0.9

1.1E−01

4.3E−02

[138]

3

Structural maintenance of chromosomes 2

NCAPG

YCG1

gCSI

12F

meiotic chromosome condensation

− 2|0.8

− 0.8|− 0.6

7.9E−01

9.2E−06

[138]

3

Non-SMC condensin I complex subunit G

NCAPD2

YCS4

gCSI

12F

meiotic chromosome condensation

− 2.4|0.8

− 1.7|− 0.9

2.3E−01

1.7E−03

NA

2

Non-SMC condensin I complex subunit D2

USP44

UBP8

GDSC

12F

histone deubiquitination

− 2|0.8

0.3|0.3

4.1E−04

6.1E−01

NA

2

Ubiquitin specific peptidase 44

KDM2B

JHD1

Both

12F

Histone Demethylation

0.2|− 0.2

− 2.3|1.9

4.6E−02

3.5E−02

[206,207,208]

1

Lysine demethylase 2B

AMD1

SPE2

Both

12F

spermine biosynthetic process

0.2|− 0.2

− 2.8|0.5

1.7E−02

1.5E−04

[200]

1

Adenosylmethionine decarboxylase 1

SMS

SPE4

gCSI

12F

spermine biosynthetic process

− 0.8|0.4

− 2.4|1

NA

3.9E−02

NA

1

Spermine synthase

EIF3I

TIF34

gCSI

12F

translation reinitiation

1.2|0

− 3.9|1.4

8.2E−01

7.1E−05

NA

2

Eukaryotic translation initiation factor 3 subunit I

STRAP

TIF34

gCSI

12F

translation reinitiation

1.2|0

− 3.9|1.4

6.7E−01

9.1E−03

NA

2

Serine/threonine kinase receptor-associated protein

DENR

TMA22

gCSI

12F

translation reinitiation

− 1.1|0.6

− 6.4|1.9

4.0E−01

1.9E−02

[210,211,212,213,214]

1

Density regulated re-initiation and release factor

PHF2

JHD1

GDSC

12F

Histone Demethylation

0.2|− 0.2

− 2.3|1.9

1.9E−03

6.8E−02

NA

1

PHD finger protein 2

JARID2

JHD2

GDSC

12F

Histone Demethylation

− 0.2|0.1

− 3.2|1

1.9E−03

2.5E−02

[209]

2

Jumonji and AT-rich interaction domain containing 2

  1. For column “DB”: “gCSI,” “GDSC,” or “Both” indicate UES in the gCSI, GDSC, or both databases. Column “Fig.” refers to specific figures. Columns “HLD L|K” and “HLEG L|K” contain the L and K interaction scores for HLD and HLEG media, respectively. “GDSC pval” and “gCSI pval” refer to the significance of differential gene expression in the respective databases. “Ref” refers to relevant literature citations. “H” refers to homology type: “1,” “2,” and “3” indicate 1:1, 1:many, and many:many, respectively
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Cancer & Metabolism

ISSN: 2049-3002