Fig. 7
From: A yeast phenomic model for the influence of Warburg metabolism on genetic buffering of doxorubicin
Additional respiration-specific deletion-enhancing and deletion-suppressing functions that influence doxorubicin cytotoxicity. Heatmaps depicting complete phenotypic profiles are the inset, corresponding to the plots of L-based doxorubicin-gene interaction. a Protein folding in endoplasmic reticulum and the N-terminal protein-acetylating NatC complex are largely respiratory-dependent in their deletion-enhancing influence. b DNA topological change exerts deletion-enhancing interactions in both respiratory and glycolytic contexts. c GTA-identified terms tend to be smaller in number and display greater variability in the Warburg dependence among genes sharing the same functional annotation. d Functions implicated in respiratory-dependent deletion suppression of doxorubicin toxicity