Fig. 3

Characterization of Warburg-differential, doxorubicin-gene interaction profiles. a The union of enhancers (L z-score > 2) or suppressors (L z-score ≤ 2) from the HLD and HLEG analyses totaled 2802 gene interaction profiles that were subjected to REMc (see the “Methods” section). b, c The column order is the same for all heatmaps; “+” indicates doxorubicin-gene interaction and “−“ indicates “shift” (K₀; see the “Methods” section). Interactions by K are negative (brown) if enhancing and positive (purple) if suppressing, while the signs of interaction are reversed for L (see the “Methods” section). The heatmap color scale is incremented by twos; red indicates no growth curve in the absence of doxorubicin. b First round cluster 1-0-7 has a gene interaction profile indicative of HLEG-specific deletion enhancement. c Second round clusters (2-0.7-X) are ordered left to right by strength of influence. d The pattern of distributions for the different doxorubicin-gene interaction scores (“+” columns only from panel c) summarizes respective clusters from panel c. Deletion enhancement is considered to be qualitatively stronger if observed for K in addition to L