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Fig. 6 | Cancer & Metabolism

Fig. 6

From: Characterization of the molecular changes associated with the overexpression of a novel epithelial cadherin splice variant mRNA in a breast cancer model using proteomics and bioinformatics approaches: identification of changes in cell metabolism and an increased expression of lactate dehydrogenase B

Fig. 6

Transcripts expression analysis of E-cadherin variant and LDHB in human breast tumor samples. a Quantitative expression analysis of E-cadherin variant and LDHB by real time PCR in 21 human breast tumor tissues. Samples were numbered and ordered in an ascending form according with the 2-ΔCt values obtained for the E-cadherin variant mRNA. b Transcripts levels association analysis of E-cadherin variant with LDHB in 21 human breast tumor tissues. The expression levels of both markers were indicated as low or high using the median value of E-cadherin variant and LDHB transcripts levels as cutoff values. The gray box highlights a significant association between E-cadherin variant and LDHB overexpression using the Fisher exact test (p < 0.0089). c Analysis of the LDHB mRNA expression levels in 21 human breast tumor samples divided in 2 groups according to their Ki-67 labeling index (Ki-67 < 20% and Ki-67 ≥ 20%). *p < 0.05\

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Cancer & Metabolism

ISSN: 2049-3002