Fig. 2
From: Transport-exclusion pharmacology to localize lactate dehydrogenase activity within cells
Oxamate and GSK-2837808A inhibit LDH activity in HeLa cells. a Oxamate resembles pyruvate in structure and competes with pyruvate for LDH binding. GSK-2837808A competes with NAD for LDH binding. b Different concentrations of oxamate (oxa) and GSK-2837808A (GSK) achieved a similar level of LDH inhibition, as determined by measuring lactate excreted to the HeLa extracellular media after drug treatment. All data shown are averages from groups of n = 3. n.s., no statistical difference