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Fig. 1 | Cancer & Metabolism

Fig. 1

From: A precision therapeutic strategy for hexokinase 1-null, hexokinase 2-positive cancers

Fig. 1

Subsets of cancers from a variety of tissues of origin are HK1HK2+. a HK1, HK2, and HK4 protein levels in organs. Organs were collected from two C57BL/6 male mice. b HK2 expression is upregulated in clinical liver cancer samples relative to normal liver. The TCGA_Liver dataset was obtained from OASIS (http://oasis-genomics.org), and the Roessler_Liver dataset was obtained from Oncomine (http://www.oncimine.com). Numbers after sample names indicate sample size. Bar: mean value. c HK1 and HK2 mRNA expression profiles in the TCGA_Liver Cancer dataset. Data were obtained from the cBioPortal (http://www.cbioportal.org). RSEM RNA-Seq by Expectation Maximization. d Identification of HK1HK2+ cancer cell lines present in the Cancer Cell Line Encyclopedia (CCLE) collection (http://www.cbioportal.org). Upper panel, HK1 and HK2 mRNA expression of 935 cell lines with RNASeq data in the CCLE dataset. Each data point represents one cell line. The box indicates “HK1HK2+” cell lines, defined as HK2 > 1 TPM and HK1 < 10 TPM. TPM transcripts per million. Lower panel, distribution of the CCLE HK1HK2+ cancer cell lines in a broad spectrum of cancers of different tissues of origin. e Hexokinase isoform expression in four human samples and seven human liver cancer cell lines

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