Table 2 Significantly regulated proteins in response to PHD3 silencing according to PECA analysis under hypoxia

 Q9NUQ6

SPATS2-like protein

SPATS2L DNAPTP6 SP1224

5.3018

0.0001

 P09382

Galectin-1

LGALS1

3.4357

0.0003

 P14314

Glucosidase 2 subunit beta

PRKCSH G19P1

3.2139

0.0003

 P61769

Beta-2-microglobulin

B2M CDABP0092 HDCMA22P

2.7460

0.0015

 Q15436

Protein transport protein Sec23A

SEC23A

2.2050

0.0004

 P27487

Dipeptidyl peptidase 4

DPP4 ADCP2 CD26

1.8694

0.0036

 Q9UL46

Proteasome activator complex subunit 2

PSME2

1.7724

0.0272

 P25786

Proteasome subunit alpha type-1

PSMA1 HC2 NU PROS30 PSC2

1.6456

0.0026

 Q14103

Heterogeneous nuclear ribonucleoprotein D0

HNRNPD AUF1 HNRPD

1.6446

0.0004

 P31949

Protein S100-A11

S100A11 MLN70 S100C

1.6168

0.0023

 P27816

Microtubule-associated protein 4

MAP4

1.5844

0.0000

 P16949

Stathmin

STMN1 C1orf215 LAP18 OP18

1.5535

0.0410

 P02751

Fibronectin

FN1 FN

1.4429

0.0000

 P62280

40S ribosomal protein S11

RPS11

1.3960

0.0174

 Q05682

Caldesmon

CALD1 CAD CDM

1.2817

0.0125

 Q08257

Quinone oxidoreductase

CRYZ

1.1956

0.0005

 P37837

Transaldolase

TALDO1 TAL TALDO TALDOR

1.1582

0.0015

 P62258

14-3-3 protein epsilon

YWHAE

1.1466

0.0028

 P38159

RNA-binding motif protein, X chromosome

RBMX HNRPG RBMXP1

1.1085

0.0056

 P42224

Signal transducer and activator of transcription 1-alpha/beta

STAT1

1.1037

0.0046

 P14866

Heterogeneous nuclear ribonucleoprotein L

HNRNPL HNRPL P/OKcl.14

1.0821

0.0046

 P40926

Malate dehydrogenase, mitochondrial

MDH2

1.0281

0.0050

 P61254

60S ribosomal protein L26

RPL26

1.0050

0.0203

 P18206

Vinculin

VCL

0.9917

0.0000

 P69905

Haemoglobin subunit alpha

HBA1; HBA2

0.9644

0.0410

 P39023

60S ribosomal protein L3

RPL3 OK/SW-cl.32

0.9556

0.0203

 Q09666

Neuroblast differentiation-associated protein AHNAK

AHNAK PM227

0.7447

0.0003

 Q9Y678

Coatomer subunit gamma-1

COPG1 COPG

−8.0564

0.0013

 Q9Y3D6

Mitochondrial fission 1 protein

FIS1 TTC11 CGI-135

−7.7833

0.0205

 P43686

26S protease regulatory subunit 6B

PSMC4 MIP224 TBP7

−6.7742

0.0040

 P40429

60S ribosomal protein L13a

RPL13A

−6.4755

0.0203

 P32970

CD70 antigen (CD27 ligand)

CD70 CD27L CD27LG TNFSF7

−6.1143

0.0023

 Q9Y6M1

Insulin-like growth factor 2 mRNA-binding protein 2

IGF2BP2 IMP2 VICKZ2

−5.1670

0.0104

 Q02878

60S ribosomal protein L6

RPL6 TXREB1

−4.4586

0.0133

 P28066

Proteasome subunit alpha type-5

PSMA5

−4.1528

0.0032

 P84098

60S ribosomal protein L19

RPL19

−3.7419

0.0000

 P26373

60S ribosomal protein L13

RPL13 BBC1 OK/SW-cl.46

−3.2209

0.0029

 Q6PIU2

Neutral cholesterol ester hydrolase 1

NCEH1 AADACL1 KIAA1363

−2.9792

0.0000

 P50914

60S ribosomal protein L14

RPL14

−2.5631

0.0480

 Q14566

DNA replication licencing factor MCM6

MCM6

−2.4344

0.0203

 Q13765

Nascent polypeptide-associated complex subunit alpha

NACA HSD48

−2.4075

0.0029

 P55072

Transitional endoplasmic reticulum ATPase

VCP

−2.3791

0.0375

 Q96C19

EF-hand domain-containing protein D2

EFHD2 SWS1

−2.3705

0.0061

 O76021

Ribosomal L1 domain-containing protein 1

RSL1D1 CATX11 CSIG PBK1 L12

−2.2907

0.0339

 P21980

Protein-glutamine gamma-glutamyltransferase 2

TGM2

−2.0064

0.0001

 P18669

Phosphoglycerate mutase 1

PGAM1 PGAMA CDABP0006

−1.9852

0.0000

 Q96KP4

Cytosolic non-specific dipeptidase

CNDP2 CN2 CPGL PEPA

−1.9098

0.0003

 P07437

Tubulin beta chain

TUBB TUBB5 OK/SW-cl.56

−1.7965

0.0000

 P04792

Heat shock protein beta-1

HSPB1 HSP27 HSP28

−1.7811

0.0000

 O15460

Prolyl 4-hydroxylase subunit alpha-2

P4HA2 UNQ290/PRO330

−1.7067

0.0000

 Q9Y265

RuvB-like 1

RUVBL1 INO80H NMP238 TIP49 TIP49A

−1.6956

0.0410

 P68363

Tubulin alpha-1B chain

TUBA1B

−1.4303

0.0000

 P11166

Glucose transporter 1

GLUT1 SLC2A1

−1.3864

0.0004

 P36578

60S ribosomal protein L4

RPL4 RPL1

−1.3288

0.0054

 P60174

Triosephosphate isomerase

TPI1 TPI

−1.2345

0.0104

 P05388

60S acidic ribosomal protein P0

RPLP0

−1.2313

0.0423

 P06733

Alpha-enolase

ENO1 ENO1L1 MBPB1 MPB1

−1.2069

0.0000

 P05556

Integrin beta-1

ITGB1 FNRB MDF2 MSK12

−1.1859

0.0306

 Q01813

6-phosphofructokinase, platelet type

PFKP PFKF

−1.0405

0.0016

 P63104

14-3-3 protein zeta/delta

YWHAZ

−0.9364

0.0000

 P46940

Ras GTPase-activating-like protein IQGAP1

IQGAP1 KIAA0051

−0.9120

0.0002

 P07355

Annexin A2

ANXA2 ANX2 ANX2L4 CAL1H LPC2D

−0.8935

0.0000

 P00338

l-lactate dehydrogenase A chain

LDHA PIG19

−0.7049

0.0004