Fig. 1

Mitochondrial genome (mtDNA) sequence analysis in pancreatic cancer PDCLs. a Schematic showing the approach used to map genotype:phenotype relationships in pancreatic cancer. b Distribution of somatic mtDNA mutations (red lines, n = 24) in 12 pancreatic PDCLs, showing strong bias towards variants in ETC complex I coding and control regions. ETC subunit coding regions are denoted by subunit (colour coded by ETC complex). Position of tRNAs are noted, with ticks marking 500 bp intervals. c Strong selection for non-synonymous mutants in mtDNA and 1056 nuclear genes important for mitochondrial function and metabolism in pancreatic PDCLs compared with a reference survey of mitochondrial variants in infantile mitochondrial disease (Calvo et al. [39]). Statistical comparisons performed using Chi-squared analysis