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Fig. 5 | Cancer & Metabolism

Fig. 5

From: Weight control interventions improve therapeutic efficacy of dacarbazine in melanoma by reversing obesity-induced drug resistance

Fig. 5

Proposed model of impact of obesity and weight control interventions on the outcome of dacarbazine therapy in melanoma. Obesity-associated factors impair the response of melanoma to DTIC by enhancing the levels of tumor-promoting molecules (solid red arrow marks). On the other hand, controlling obesity through weight interventions causes normalization in obesity-associated factors. This in turn improves the efficacy of DTIC through reducing in the levels of melanoma cell growth promoting molecules (dotted blue arrow marks)

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Cancer & Metabolism

ISSN: 2049-3002