Table 4 Multicategory Global test p value for pathway level associations of tumor expression of the metabolic pathways with histologic and molecular features of prostate cancer
Pathway (n genes) | Ki-67 quartiles (n = 314 men) | Apoptosis quartiles (n = 255 men) | Microvessel density quartilesa(n = 174 men) | Perineural invasiona(n = 132 men) |
|---|---|---|---|---|
Fatty acid metabolism (n = 39) | 1.8 × 10−4 | 0.20 | 0.01 | 1.1 × 10−6 |
Glycolysis/gluconeogenesis (n = 62) | 9.4 × 10−9 | 0.19 | 0.06 | 1.2 × 10−4 |
Pentose phosphate (n = 27) | 4.0 × 10−6 | 0.20 | 0.14 | 0.04 |
Purine metabolism (n = 157) | 4.1 × 10−6 | 0.42 | 0.09 | 1.9 × 10−5 |
Pyrimidine metabolism (n = 96) | 2.8 × 10−6 | 0.64 | 0.17 | 3.5 × 10−4 |
Oxidative phosphorylation (n = 123) | 3.1 × 10−8 | 0.09 | 2.0 × 10−3 | 0.02 |
TCA (n = 30) | 1.1 × 10−7 | 0.30 | 0.04 | 0.37 |