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Fig. 4 | Cancer & Metabolism

Fig. 4

From: Metabolic clusters of breast cancer in relation to gene- and protein expression subtypes

Fig. 4

Illustration of metabolic pathways reported to have altered gene and metabolite expression by integrated pathway analysis (MetaboAnalyst). a Result within “glycolysis/glutaminolysis” genes and metabolites differently expressed in metabolic cluster (Mc) Mc2 compared to Mc1. Adapted from KEGG ID: hsa00010. LDHB lactate dehydrogenase B; ADH1A/ADH1B/ADH1C alcohol dehydrogenase 1A/1B/1C; ALDH1A3: aldehyde dehydrogenase 1 family member A3; ALDH2 aldehyde dehydrogenase 2 family; ACSS1 acetate CoA ligase; TCA cycle trucarboxylic acid cycle. b Result within “glycerophospholipid metabolism” of genes and metabolites differently expressed in Mc1 compared to Mc2. Adapted from KEGG ID: hsa00564. CHKA choline kinase alpha; PCYT1A phosphate cytidylytransferase 1; CEPT1 choline/ethanolamine phosphotransferase 1; PLA2G5 phospholipase A2; LCAT lecithin-cholesterol acyltransferase; LPCAT2 lysophosphatidyl-choline acyltransferase; PC-PLD phospholipase D; Lyso-PLA1 lysophospholipase I; GPC-PDE glycerophos-phocholine phosphodiesterase; PLC phospholipase C; PLD1 phospholipidase D1; PPAP2A, PPAP2B phosphatidate phosphatase LPIN; AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase

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