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Figure 4 | Cancer & Metabolism

Figure 4

From: Succinate dehydrogenase inhibition leads to epithelial-mesenchymal transition and reprogrammed carbon metabolism

Figure 4

Sdhb knockdown leads to a hypermethylated epigenome; small-molecule inhibition of H3K27 demethylases phenocopies loss of Sdhb. (A) Western blot of various histone methylation marks with Histone H3 as a loading control. (B) Bright field microscopy of untreated cells or cells treated with indicated concentrations of GSK-J1 or GSK-J4 for 4 days. (C) Immunofluorescent microscopy of cells stained for E-cadherin (green) and DAPI (blue). (D) Quantification of Snai1, Snai2, and Twist2 mRNA relative to Gapdh. *p value < .01.

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Cancer & Metabolism

ISSN: 2049-3002