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Figure 5 | Cancer & Metabolism

Figure 5

From: SIRT3 and SIRT4 are mitochondrial tumor suppressor proteins that connect mitochondrial metabolism and carcinogenesis

Figure 5

Schema outlining the multiple mechanisms by which SIRT3 blocks ROS production, thereby preventing carcinogenesis. Loss of SIRT3 results in mitochondrial dysregulation as well as increased ROS, due in part to increased mitochondrial protein acetylation, including that in MnSOD, and decreased MnSOD detoxification activity as well as other downstream target proteins deacetylated by SIRT3. The increase in ROS is thought to be an early event in the in vivo carcinogenesis observed in mice lacking Sirt3.

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Cancer & Metabolism

ISSN: 2049-3002