Effects of caloric restriction on murine survival and carcinogenesis. (A) Overall survival or longevity in mice on a standard ad libitum diet or CR diets consisting of 85, 50, or 40 kcal/week. The black circles highlight the inflection points of the survival curves on the ad libitum and 40 kcal/week diets. (B) The incidence of pancreatic cancers in an LSL-KrasG12D genetic knock-in mouse model on either an ad libitum diet or a CR diet. Results are presented as %survival or %tumor free, respectively, as a function of mouse age.