Figure 7

Upregulation of some inflammatory genes due to fibroblast growth factor receptor (FGFR)4 deficiency. Changes in expression of IFNγ (A), TNFα (B), IL-6 (C) and Cyclooxygenase (Cox)2 (D) in the breast and breast tumor tissues from wild-type (WT), FGFR4 knockout (KO), MMTV-TGFα transgenic (Tg) and FGFR4^−/−: MMTV-TGFα bigenic (KO-Tg) mice at 6 months were determined by quantitative PCR. mRNA levels were normalized to β-actin levels in the respective samples and then expressed as fold changes relative to that of the WT breast, which is assigned as an arbitrary unit of 1. Data are means ± SD; P <0.05 (n = 4 for each group).