Metabolic flux distribution as a function of the protein synthesis rate. (a-j) Selected metabolic pathways are shown. Shown are rates of the reaction indicated in the y-axis as a function of the maximum likelihood estimate (MLE) protein synthesis rate (x-axis) for the NCI60 cell lines. Panels with no error bars represent exchange fluxes that were used as input to the model. Panels with error bars represent flux estimates using our personalized metabolic models. In the latter, each point represents the median over the range of kinetic parameters explored (Additional file 1) and the error bars represent the 90% CI. The dashed lines are linear fits through the origin.