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Table 1 Concentrations of selected metabolites in Shh- or vehicle-containing CGNP media at the indicated times

From: Hexokinase-2-mediated aerobic glycolysis is integral to cerebellar neurogenesis and pathogenesis of medulloblastoma

  Shh Vehicle ΔShh vs. ΔV
0 hours (μM) 6 hours (μM) Δ6 hours (μM) 0 hours (μM) 6 hours (μM) Δ6 hours (μM) P value
Acetate 109 ± 5 105 ± 2 −4 ± 5 111 ± 3 127 ± 7 15 ± 8 >0.05
Alanine 160 ± 4 394 ± 4 234 ± 6 165 ± 6 348 ± 13 183 ± 15 >0.05
Arginine 997 ± 49 1,002 ± 22 5 ± 53 990 ± 16 989 ± 26 −2 ± 30 >0.05
Glucose 196,834 ± 934 17,312 ± 328 −2,372 ± 990 19,449 ± 749 19,399 ± 405 −49 ± 852 <0.001
Glutamine 2,443 ± 99 2,037 ± 31 −407 ± 103 2,509 ± 92 2,515 ± 65 6 ± 113 >0.05
Glycine 223 ± 21 221 ± 6 −2 ± 22 215 ± 10 254 ± 8 39 ± 13 >0.05
Lactate 334 ± 27 4,952 ± 114 4,618 ± 117 299 ± 15 2,012 ± 49 1,713 ± 51 <0.001
Leucine 578 ± 29 483 ± 17 −95 ± 33 555 ± 23 560 ± 4 5 ± 23 >0.05
Threonine 461 ± 30 484 ± 37 23 ± 47 413 ± 14 487 ± 14 74 ± 20 >0.05
Valine 558 ± 14 499 ± 21 −59 ± 24 540 ± 22 552 ± 17 12 ± 28 >0.05